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Bychkova N.Yu.

Biomedical University of Innovation and Continuing Education, State Scientific Center of the Russian Federation — Burnazyan Federal Medical Biophysical Center;
Patrice Lumumba Peoples’ Friendship University of Russia

Chaikovskaya E.A.

Institute of Plastic Surgery and Cosmetology

Naumchik G.A.

Clinic for Cosmetology and Integrative Medicine “Nogerov International Clinic”

Zakharov D.Yu.

Clinic Network “Linline”

Kazakov S.P.

INGAL LLC;
Clinic “Cosmetology Premium”

Efficacy and safety of dermal filler based on poly-D,L-lactic acid

Authors:

Bychkova N.Yu., Chaikovskaya E.A., Naumchik G.A., Zakharov D.Yu., Kazakov S.P.

More about the authors

Journal: Plastic Surgery and Aesthetic Medicine. 2025;(3): 38‑48

DOI: 10.17116/plast.hirurgia202503138

Read: 972 times

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Table of contents

EFFICACY AND SAFETY OF DERMAL FILLER BASED ON POLY-D,L-LACTIC ACID
EFFICACY AND SAFETY OF DERMAL FILLER BASED ON POLY-D,L-LACTIC ACID

To cite this article:

Bychkova NYu, Chaikovskaya EA, Naumchik GA, Zakharov DYu, Kazakov SP. Efficacy and safety of dermal filler based on poly-D,L-lactic acid. Plastic Surgery and Aesthetic Medicine. 2025;(3):38‑48. (In Russ., In Engl.)
https://doi.org/10.17116/plast.hirurgia202503138

Подписка 2026 Пластическая хирургия и эстетическая медицина (Plastic Surgery and Aesthetic Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

Assessment of the effectiveness, safety and satisfaction of patients and doctors after procedures for the administration of polylactic acid suspension Repart PLA.

MATERIAL AND METHODS

The study involved 42 patients (37 women and 5 men) aged 32-65 years who underwent double implantation of the Repair PLA filler in the middle and lower thirds of the face with an interval of 2 months according to the established protocol. The condition of the facial skin was assessed before, during and after the course of procedures. Photo documentation and assessment of the skin condition of the face were performed using photo scales. Ultrasound skin scanning, elastometry, and elastography were performed. The GAIS scale was used to analyze the satisfaction of doctors and patients with treatment results. Throughout the study, the safety and tolerability of the procedures were monitored.

RESULTS

The positive dynamics of structural changes in the skin was noted after the first procedure, followed by an increase in the clinical effect for all analyzed parameters. After two procedures of administration of the Repart PLA suspension, an improvement in the condition of the middle and lower parts of the face (4 indicators) and skin quality (4 indicators) was observed in 90% of the participants, and this trend continued throughout the follow-up period. 93% of the participants rated the result as “good” and “excellent” after the first procedure and 98% of the participants after the second procedure. Patients noted good tolerability of the procedure, which does not require additional methods of anesthesia. No unpredictable adverse events were detected after the administration of Repart PLA.

CONCLUSION

The filler based on poly-D,L-lactic acid Repart PLA has shown its effectiveness and safety in correcting the involutional changes of the middle and lower thirds of the face.

Keywords:

polylactic acid
poly-D
L-lactic acid
skin quality
dermal implants
rejuvenation
collagen stimulation

Authors:

Bychkova N.Yu.

Biomedical University of Innovation and Continuing Education, State Scientific Center of the Russian Federation — Burnazyan Federal Medical Biophysical Center;
Patrice Lumumba Peoples’ Friendship University of Russia

Chaikovskaya E.A.

Institute of Plastic Surgery and Cosmetology

Naumchik G.A.

Clinic for Cosmetology and Integrative Medicine “Nogerov International Clinic”

Zakharov D.Yu.

Clinic Network “Linline”

Kazakov S.P.

INGAL LLC;
Clinic “Cosmetology Premium”

Received:

26.05.2025

Accepted:

18.06.2025

Close metadata

References:

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