Macroscopic structure of peyer’s plaques of small intestine of rats and changes in the intestine when exposed to chronic radiation

Teshaev Sh.Zh.; Khasanova D.A.

doi:https://doi.org/10.17116/operhirurg2020401141

Teshaev Sh.Zh.

Abu Ali ibn Sino Bukhara State Medical Institute, Bukhara, Uzbekistan

Khasanova D.A.

Abu Ali ibn Sino Bukhara State Medical Institute, Bukhara, Uzbekistan

Macroscopic structure of peyer’s plaques of small intestine of rats and changes in the intestine when exposed to chronic radiation

Authors:

Teshaev Sh.Zh., Khasanova D.A.

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Journal: Russian Journal of Operative Surgery and Clinical Anatomy. 2020;4(1): 41‑45

DOI: 10.17116/operhirurg2020401141

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To cite this article:

Teshaev ShZh, Khasanova DA. Macroscopic structure of peyer’s plaques of small intestine of rats and changes in the intestine when exposed to chronic radiation. Russian Journal of Operative Surgery and Clinical Anatomy. 2020;4(1):41‑45. (In Russ.)
https://doi.org/10.17116/operhirurg2020401141

Подписка 2026 Оперативная хирургия и клиническая анатомия (Пироговский научный журнал) (Russian Journal of Operative Surgery and Clinical Anatomy)

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Abstract:

Aim of study — study of the quantitative content of lymphoid structures (Peyer’s plaques) of the small intestine in 6-month-old rats in normal condition and when exposed to chronic radiation sickness. Material and methods. The study was performed on 40 white randomly bred male rats weighing from 215 to 320 g, kept under vivarium conditions with a standard diet, free access to water, and normal lighting conditions. Animals (n=40) were divided into 2 groups of 20 individuals: 1st (control), 2nd — after chronic exposure. To simulate chronic radiation sickness, rats were irradiated with the AGAT R1 DTGT apparatus (Baltiets plant, Narva, Estonia, 1991 year of production, operation since 1994, recharge 2017), with a capacity of 25.006 cGy/min for 20 days at a dose 0.2 Gy (total dose of 4.0 Gy) up to 90 days of age. Mathematical processing of the obtained data was carried out according to the method of variation statistics using the Statistika 7.0 application software packages. Statistical processing of the data was carried out according to the method of variation statistics using the software packages «Statistika 7.0» and Microsoft Office Excel-2012. Results. When modeling chronic radiation sickness on the 180th day of the experiment, a significant decrease in the number of Peyer’s plaques in irradiated rats was revealed compared with control group of intact animals, at the same time the number of nodules in them and the size of Peyer’s plaques relatively increased from the initial part of the small intestine to the ending part. On average, 2.38% of the small intestine area of irradiated rats is covered with Peyer’s plaques, in contrast to healthy ones (2.71%; p<0.05). These facts indicate a decrease in the functional activity of the intestinal lymphoid tissue after exposure to chronic radiation. Conclusions. In a rat experiment, the morphological changes in the lymphoid formations of various sections of the small intestine were compared under normal conditions and in chronic radiation sickness. It was found that after exposure to chronic radiation, the functional activity of the intestinal lymphoid tissue decreases.

Keywords:

small intestine

immune system

Peyer’s plaques

single lymphoid nodules

nodular shape

chronic radiation sickness

Authors:

Teshaev Sh.Zh.

Abu Ali ibn Sino Bukhara State Medical Institute, Bukhara, Uzbekistan

Khasanova D.A.

Abu Ali ibn Sino Bukhara State Medical Institute, Bukhara, Uzbekistan

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