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Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Rukhadze G.O.

A.F. Tsyba Medical Radiological Research Centre — Branch of the National Medical Research Center of Radiology of the Ministry of Healthcare of the Russia, Obninsk, Russia

Kostyuk I.P.

A.F. Tsyb Medical Radiology Research Centre, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk

Shinkarkina A.P.

A.F. Tsyb Medical Radiology Research Centre, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk

Mozerov S.A.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia

Dvinskikh N.Yu.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia

A case of treatment for giant gastrointestinal stromal tumor of the stomach with metastases in the serous membrane of the small intestine

Authors:

Kaprin A.D., Rukhadze G.O., Kostyuk I.P., Shinkarkina A.P., Mozerov S.A., Dvinskikh N.Yu.

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Journal: P.A. Herzen Journal of Oncology. 2017;6(2): 45‑50

DOI: 10.17116/onkolog20176245-50

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Table of contents

A CASE OF TREATMENT FOR GIANT GASTROINTESTINAL STROMAL TUMOR OF THE STOMACH WITH METASTASES IN THE SEROUS MEMBRANE OF THE SMALL INTESTINE
A CASE OF TREATMENT FOR GIANT GASTROINTESTINAL STROMAL TUMOR OF THE STOMACH WITH METASTASES IN THE SEROUS MEMBRANE OF THE SMALL INTESTINE

To cite this article:

Kaprin AD, Rukhadze GO, Kostyuk IP, Shinkarkina AP, Mozerov SA, Dvinskikh NYu. A case of treatment for giant gastrointestinal stromal tumor of the stomach with metastases in the serous membrane of the small intestine. P.A. Herzen Journal of Oncology. 2017;6(2):45‑50. (In Russ.)
https://doi.org/10.17116/onkolog20176245-50

 
Подписка 2025-2 (P.A. Herzen Journal of Oncology)
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Gastrointestinal stromal tumor (GIST) is a rare tumor of the digestive system. GIST does not show any specific symptoms. These tumors are usually asymptomatic for a long time and can present with bleeding or obstruction, which causes the patient to seek medical advice, as well as when he/she himself/herself finds a larger tumor. Treatment is sometimes denied wrongfully to such patients. The results of treatment in patients with GIST largely depend on the quality of the performed surgical intervention and on the determination of tumor susceptibility to adjuvant therapy. The paper gives an example of successful treatment in a patient with a large GIST.

Keywords:

gastrointestinal stromal tumor
c-Kit and PDGFRα gene mutations
Carney triad
neurofibromatosis
R0 resection
imatinib mesylate
Gleevec
immunohistochemical markers

Authors:

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

Rukhadze G.O.

A.F. Tsyba Medical Radiological Research Centre — Branch of the National Medical Research Center of Radiology of the Ministry of Healthcare of the Russia, Obninsk, Russia

Kostyuk I.P.

A.F. Tsyb Medical Radiology Research Centre, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk

Shinkarkina A.P.

A.F. Tsyb Medical Radiology Research Centre, Branch, National Medical Radiology Research Center, Ministry of Health of Russia, Obninsk

Mozerov S.A.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia

Dvinskikh N.Yu.

A.F. Tsyb Medical Radiology Research Center, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Obninsk, Russia

List of references:

  1. Seryakov AP. Gastrointestinal stromal tumors. Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2010;20(4):49-57. (In Russ.)
  2. Gheorghe M, Predescu D, Iosif C, Ardeleanu C, Băcanu F, Constantinoiu S. Clinical and therapeutic considerations of GIST. J Med Life. 2014;7(2):139-149.
  3. Lech G, Korcz W, Kowalczyk E, Guzel T, Radoch M, Krasnodębski IW. Giant gastrointestinal stromal tumour of rare sarcomatoid epithelioid subtype: Case study and literature review. World J Gastroenterol. 2015;21(11):3388-3393.
  4. Güller U, Tarantino I, Cerny T, Schmied B, Warschkow R. Population-based SEER trend analysis of overall and cancer-specific survival in 5138 patients with gastrointestinal stromal tumor. BMC Cancer. 2015;15:557. doi:10.1186/s12885-015-1554-9
  5. Ionescu S, Barbu E, Ionescu C, Costache A, Bălăşoiu M. Giant gastrointestinal stromal tumor of the stomach. Rom J Morphol Embryol. 2015;56(1):239-245.
  6. Pracucho EM, Lopes LR, Zanatto RM, Tomal KT, Passeri CR, Molan JR, Prado Ade A. Profile of patients with gastrointestinal stromal tumors (GIST). Arq Bras Cir Dig. 2015;28(2):124-127. doi:10.1590/s0102-67202015000200010
  7. Graziosi L, Marino E, Ludovini V, Rebonato A, Angelis V, Donini A. Unique case of sporadic multiple gastro intestinal stromal tumour. Int J Surg Case Rep. 2015;9:98-100. doi:10.1016/j.ijscr.2015.01.025
  8. Koumarianou A, Economopoulou P, Katsaounis P, Laschos K, Arapantoni-Dadioti P, Martikos G, et al. Gastrointestinal Stromal Tumors (GIST): A prospective analysis and an update on biomarkers and current treatment concepts. Biomark Cancer. 2015;7(Suppl.1):1-7. doi:10.4137/BIC.S25045. eCollection 2015
  9. Fletcher C, Berman J, Corless C, Gorstein F, Lasota J, Longley B, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002;33(5):459-465.
  10. Miettinen M, Lasota J. Gastrointestinal stromal tumors: pathology and prognosis at different sites. Semin Diagn Pathol. 2006;23(2):70-83. doi:10.1053/j.semdp.2006.09.001
  11. Gauthé M, Richard-Molard M, Cacheux W, Michel P, Jouve J, Mitry E, et al. Role of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography in gastrointestinal cancers. Dig Liver Dis. 2015;47(6):443-454. doi:10.1016/j.dld.2015.02.005
  12. ESMO/European Sarcoma Network Working Group. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2014;25(Suppl.3):iii21-26. doi:10.1093/annonc/mdu255
  13. Eisenberg B, Harris J, Blanke C, Demetri G, Heinrich M, Watson J, et al. Phase II trial of neoadjuvant/adjuvant imatinib mesylate (IM) for advanced primary and metastatic/recurrent operable gastrointestinal stromal tumor (GIST): Early results of RTOG 0132/ACRIN 6665. J Surg Oncol. 2009;99(1):42-47.
  14. Neofytou K, Costa Neves M, Giakoustidis A, Benson C, Mudan S. Effective downsizing of a large oesophageal gastrointestinal stromal tumour with neoadjuvant imatinib enabling an uncomplicated and without tumour rupture laparoscopic-assisted ivor-lewis oesophagectomy. Case Rep Oncol Med. 2015;2015:165736. doi:10.1155/2015/165736
  15. Yanagawa S, Tanabe K, Suzuki T, Tokumoto N, Arihiro K Ohdan H. A large esophageal gastrointestinal stromal tumor that was successfully resected after neoadjuvant imatinib treatment: case report. World J Surg Oncol. 2014;12(1):47. doi:10.1186/1477-7819-12-47
  16. Melichar B, Voboril Z, Nozicka J, Ryska A, Urminská H, Vanecek T, Michal M. Pathological complete response in advanced gastrointestinal stromal tumor after imatinib therapy. Intern Med. 2005;44(11):1163-1168. doi:10.2169/internalmedicine.44.1163

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