Gene therapy is a new area in medicine

Bezborodova O.A.; Nemtsova E.R.; Iakubovskaia R.I.; Kaprin A.D.

doi:https://doi.org/10.17116/onkolog20165264-72

Bezborodova O.A.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Nemtsova E.R.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Iakubovskaia R.I.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

Gene therapy is a new area in medicine

Authors:

Bezborodova O.A., Nemtsova E.R., Iakubovskaia R.I., Kaprin A.D.

More about the authors

Journal: P.A. Herzen Journal of Oncology. 2016;5(2): 64‑72

DOI: 10.17116/onkolog20165264-72

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To cite this article:

Bezborodova OA, Nemtsova ER, Iakubovskaia RI, Kaprin AD. Gene therapy is a new area in medicine. P.A. Herzen Journal of Oncology. 2016;5(2):64‑72. (In Russ.)
https://doi.org/10.17116/onkolog20165264-72

Подписка 2026 Онкология. Журнал им. П.А. Герцена (P.A. Herzen Journal of Oncology)

Использование инфографики авторами научных работ

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Abstract:

The review gives information on the history and areas of gene therapy development. It discusses the types of transgenes used to treat different diseases; specific and constitutional promoters that ensure the expression of therapeutic transgenes in targeted cells; procedures for delivering gene constructions into the targeted cells; and mechanisms by which the genetic material is introduced into the cell nucleus. The advantages and disadvantages of various types of viral and nonviral vectors are considered in detail. There is recent evidence on the clinical application of officinal drugs for gene therapy, which are registered for the treatment of patients with head and neck cancer (Gendicine and Oncorine, China), the monogenic disease lipoprotein lipase deficiency (Glybera, the Netherlands), or atherosclerotic lower extremity ischemia (Neovaskulgen, Russia), and on clinical tests of medications for gene therapy in different fields of medicine.

Keywords:

gene therapy

transgene

promoter

vector

Authors:

Bezborodova O.A.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Nemtsova E.R.

P.A. Herzen Moscow Oncology Research Institute, Branch, National Medical Radiology Research Center, Ministry of Health of the Russian Federation, Moscow, Russia

Iakubovskaia R.I.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdravsotsrazvitiia Rossii

Kaprin A.D.

FGBU "Moskovskiĭ nauchno-issledovatel'skiĭ onkologicheskiĭ institut im. P.A. Gertsena" Minzdrava Rossii

SPIN RSCI: 1759-8101
Scopus AuthorID: 6602709853
ResearcherID: K-1445-2014
ORCID: 0000-0001-8784-8415

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