Objective — to assess the experience of combined and combination treatment in 64 patients with locally advanced epithelial oropharyngeal tumors, treated at the P.A. Herzen Moscow Oncology Research Institute in 1991 to 1998. Subjects and methods. The patients’ age ranged from 16 to 85 years. All the patients had epithelial tumors; Stage III and IV cancer was detected in 70 and 30%, respectively. Squamous cell carcinoma was predominant (77%). There were primary oropharyngeal tumors in 14 (21.8%) patients and tumors of the buccal mucosa in 12 (18.7%) cases, mouth floor in 19 (29.7%), tongue in 11 (17.2%), and the mucosa of the upper and lower jaw alveolar processes in 8 (12.5%). All the patients received combined or combination treatment. Preoperative beam therapy at a total radiation dose (TRD) of 38.4-40 Gy was performed in 18 (28%) patients; preoperative chemoradiotherapy in 34 (53%) cases (dynamic dose fractionation with radiosensitization with 5-fluorouracil and platinum preparations) and intraoperative radiotherapy at a TRD of 15—25 Gy in 12 (19%) cases. Resection and reconstructive stages were simultaneously performed in all the patients. A microsurgical tissue autotransplantation technique was used. Costomuscular, visceral, musculocutaneous, and fasciocutaneous flaps were employed as plastic material. Results. Engraftment was achieved in 95.3% of cases. The postoperative period was noted to be complicated in 29 (64.4%) patients. Total and partial flap necrosis developed in 3 (4.7%) and 3 (4.7%) patients, respectively. A low mortality rate (2.2%) was observed in our investigation. Oral feeding was restored in 83.3%. Decannulation was carried out in 85% of cases, in 35% of the patients within 15—30 days; 40% of the patients were decannulated within 1 to 3 months. Conditions were created in 76.6% for orthotopic tooth replacement that was made in 16.6% of the patients within 5 to 32 months after reparative operations. 88.6% of the patients were rehabilitated. Overall 3- and 5-year survival rates were 57.2 and 53.3%, respectively. Ten (15.6%) patients survived 15 years. Conclusion. All these patients were completely functionally and socially adapted. Natural solid food feeding, breathing, and articulation completely recovered. All the patients underwent diverse tooth replacement. The patients lead an adequate family life and 2 patients had spontaneous pregnancies and gave birth to healthy babies. 86.4% of the patients were socially adapted and 31.8% returned to socially useful work.