The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Ekusheva E.V.

Federal Research and Clinical Center of Specialized Types of Health Care and Medical Technology of the Federal Medical and Biological Agency

12 reasons to prescribe vitamin B12

Authors:

Ekusheva E.V.

More about the authors

Journal: Non Nocere. New Therapeutic Journal. 2025;(8): 66‑72

Read: 129 times

Buy for 300₽
Contact the author
Table of contents

To cite this article:

Ekusheva EV. 12 reasons to prescribe vitamin B12. Non Nocere. New Therapeutic Journal. 2025;(8):66‑72. (In Russ.)

 
 
 
ЭндоКард
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Abstract:

List of diseases.

Authors:

Ekusheva E.V.

Federal Research and Clinical Center of Specialized Types of Health Care and Medical Technology of the Federal Medical and Biological Agency

Close metadata

References:

  1. Green R, Allen LH, Bjørke-Monsen AL, et al. Vitamin B12 deficiency. Nat Rev Dis Primers. 2017 Jun 29;3:17040. https://doi.org/10.1038/nrdp.2017.40
  2. Means RT, Fairfield KM. Clinical manifestations and diagnosis of vitamin B12 and folate deficiency. UpTjDate (access 07.08.2023). https://medilib.ir/uptodate/show/7155
  3. Resolution of the Advisory Board “Deficiency/Deficit of vitamin B12 in clinical practice”. Russian Journal of Preventive Medicine. 2023;26(1):109-113. (In Russ.) https://doi.org/10.17116/profmed202326011109
  4. Choudhury A, Jena A, Jearth V, et al. Vitamin B12 deficiency and use of proton pump inhibitors: a systematic review and meta-analysis. Expert Rev Gastroenterol Hepatol. 2023 May;17(5):479-487.  https://doi.org/10.1080/17474124.2023.2204229
  5. Jung SB, Nagaraja V, Kapur A, Eslick GD. Association between vitamin B12 deficiency and long-term use of acid lowering agents: a systematic review and meta-analysis. Intern Med J. 2015 Apr;45(4):409-416.  https://doi.org/10.1111/imj.12697
  6. Linder L, Tamboue C, Clements JN. Drug-Induced Vitamin B12 Deficiency: A Focus on Proton Pump Inhibitors and Histamine-2 Antagonists. J Pharm Pract. 2017 Dec;30(6): 639-642.  https://doi.org/10.1177/0897190016663092
  7. Devalia V, Hamilton MS, Molloy AM. British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014 Aug;166(4):496-513.  https://doi.org/10.1111/bjh.12959
  8. Jensen CF. Vitamin B12 levels in children and adolescents on plant-based diets: a systematic review and meta-analysis. Nutr Rev. 2023 Jul 10;81(8):951-966.  https://doi.org/10.1093/nutrit/nuac096
  9. Kwon Y, Kim HJ, Lo Menzo E, et al. Anemia, iron and vitamin B12 deficiencies after sleeve gastrectomy compared to Roux-en-Y gastric bypass: a meta-analysis. Surg Obes Relat Dis. 2014 Jul–Aug;10(4):589-597.  https://doi.org/10.1016/j.soard.2013.12.005
  10. Rogne T, Tielemans MJ, Chong MF, et al. Associations of Maternal Vitamin B12 Concentration in Pregnancy with the Risks of Preterm Birth and Low Birth Weight: A Systematic Review and Meta-Analysis of Individual Participant Data. Am J Epidemiol. 2017 Feb 1;185(3):212-223.  https://doi.org/10.1093/aje/kww212
  11. Rashid S, Meier V, Patrick H. Review of Vitamin B12 deficiency in pregnancy: a diagnosis not to miss as veganism and vegetarianism become more prevalent. Eur J Haematol. 2021 Apr;106(4):450-455.  https://doi.org/10.1111/ejh.13571
  12. Andrès E, Loukili NH, Noel E, et al. Vitamin B12 (cobalamin) deficiency in elderly patients. CMAJ. 2004;171(3):251-259.  https://doi.org/10.1503/cmaj.1031155
  13. Lakhani SV, Shah HN, Alexander K, Finelli FC, Kirkpatrick JR, Koch TR. Small intestinal bacterial overgrowth and thiamine deficiency after Roux En-Y gastric bypass surgery in obese patients. Nutr Res. 2008;28(5):293-298.  https://doi.org/10.1016/j.nutres.2008.03.002
  14. Kwon Y, Ha J, Lee YH, et al. Comparative risk of anemia and related micronutrient deficiencies after Roux‐en‐Y gastric bypass and sleeve gastrectomy in patients with obesity: An updated meta‐analysis of randomized controlled trials. Obes Rev. 2022;4(23):e13419. https://doi.org/10.1111/obr.13419
  15. Hagopian W, Lee HS, Liu E, et al. TEDDY Study Group. Cooccurrence of type 1 diabetes and celiac disease autoimmunity. Pediatrics. 2017;140(5):e20171305. https://doi.org/10.1542/peds.2017-1305
  16. Mrozikiewicz-Rakowska B, Chylinska A, Sienko D. Vitamin B12 in diabetes – a new treatment paradigm? Clin Diabetol. 2020;9(6):489-496.  https://doi.org/10.5603/DK.2020.0060
  17. Alharbi TJ, Tourkmani AM, Abdelhay O, et al. The association of metformin use with vitamin B12 deficiency and peripheral neuropathy in Saudi individuals with type 2 diabetes mellitus. PLoS One. 2018;13(10): e0204420. https://doi.org/10.1371/journal.pone.0204420
  18. Benites-Zapata VA, Ignacio-Cconchoy FL, Ulloque-Badaracco JR, et al. Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis. Front Endocrinol (Lausanne). 2023;14:1070592. https://doi.org/10.3389/fendo.2023.1070592
  19. Clauson KA. Drug-Induced Diseases: Prevention, Detection, and Management. Am J Pharm Educ. 2006;70(6):148. 
  20. Marsden P, Sharma AA, Rotella JA. Review article: Clinical manifestations and outcomes of chronic nitrous oxide misuse: A systematic review. Emerg Med Australas. 2022;34(4):492-503.  https://doi.org/10.1111/1742-6723.13997
  21. Khattab R, Albannawi M, Alhajjmohammed D, et al. Metformin-induced vitamin B12 deficiency among type 2 diabetes mellitus’ patients: a systematic review. Curr Diabetes Rev. 2023;19(4):e180422203716. https://doi. org/10.2174/1573399818666220418080959 
  22. Chapman LE, Darling AL, Brown JE. Association between metformin and vitamin B12 deficiency in patients with type 2 diabetes: A systematic review and meta-analysis. Diabetes Metab. 2016;42(5):316-327.  https://doi.org/10.1016/j.diabet.2016.03.008
  23. Linnebank M, Moskau S, Semmler A, et al. Antiepileptic drugs interact with folate and vitamin B12 serum levels. Ann Neurol. 2011;69(2):352-359.  https://doi.org/10.1002/ana.22229
  24. Lam JR, Schneider JL, Zhao W, Corley DA. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA. 2013;310(22):2435-2442. https://doi.org/10.1001/jama.2013.280490
  25. Miller JW. Proton Pump Inhibitors, H2-Receptor Antagonists, Metformin, and Vitamin B12 Deficiency: Clinical Implications. Adv Nutr. 2018;9(4):511S-518S. https://doi.org/10.1093/advances/nmy023
  26. Dharmarajan TS, Kanagala MR, Murakonda P, Lebelt AS, Norkus EP. Do acid-lowering agents affect vitamin B12 status in older adults? J Am Med Dir Assoc. 2008;9(3):162-167.  https://doi.org/10.1016/j.jamda.2007.10.004
  27. Dries LS, Haefliger R, Seibert BS, de Lima AG, Cardoso CO, Perassolo MS. Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use. J Pharm Pharmacol. 2022;74(4):547-555.  https://doi.org/10.1093/jpp/rgab001
  28. Parlesak A, Klein B, Schecher K, Bode JC, Bode C. Prevalence of small bowel bacterial overgrowth and its association with nutrition intake in nonhospitalized older adults. J Am Geriatr Soc. 2003;51(6):768-773.  https://doi.org/10.1046/j.1365-2389.2003.51259.x
  29. Batista KS, Cintra VM, Lucena PAF, et al. The role of vitamin B12 in viral infections: a comprehensive review of its relationship with the muscle-gut-brain axis and implications for SARS-CoV-2 infection. Nutr Rev. 2022;80(3):561-578.  https://doi.org/10.1093/nutrit/nuab092
  30. Kulkarni R, Rajput U, Dawre R, et al. Severe malnutrition and anemia are associated with severe Covid in infants. J Trop Pediatr. 2021;67(1): fmaa084. https://doi.org/10.1093/tropej/fmaa084
  31. dos Santos LMJ. Can vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biol Pharm Sci. 2020;11(03):001-005.  https://doi.org/10.30574/gscbps.2020.11.3.0155
  32. Methodological recommendations “Features of Long COVID infection. Therapeutic and rehabilitation measures.” Therapy. 2022;1(Appendix):1-147.  https://doi.org/10.18565/therapy.2022.1suppl.1-147
  33. Kandeel M, Al-Nazawi M. Virtual screening and repurposing of FDA approved drugs against COVID-19 main protease. Life Sci. 2020;251:117627. https://doi.org/10.1016/j.lfs.2020.117627
  34. Hunt A, Harrington D, Robinson S. Vitamin B12 deficiency. BMJ. 2014;349:g5226. https://doi.org/10.1136/bmj.g5226
  35. Hannibal L, Lysne V, Bjørke-Monsen AL, et al. Biomarkers and Algorithms for the Diagnosis of Vitamin B12 Deficiency. Front Mol Biosci. 2016;3:27-42.  https://doi.org/10.3389/fmolb.2016.00027
  36. Robert T Means, Jr, Kathleen M Fairfield. Clinical manifestations and diagnosis of vitamin B12 and folate deficiency. (access 05.09.2025). https://www.uptodate.com/contents/clinical-manifestations-and-diagnosis-of-vitamin-b12-and-folate-deficiencies
  37. Sanz-Cuesta T, González-Escobar P, Riesgo-Fuertes R, et al. OB12 Group. Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12). BMC Public Health. 2012;12:394.  https://doi.org/10.1186/1471-2458-12-394
  38. Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2018;3(3): CD004655. https://doi.org/10.1002/14651858.CD004655.pub3
  39. Eussen SJ, de Groot LC, Clarke R, et al. Oral cyanocobalamin supplementation in older people with vitamin B12 deficiency: a dose-finding trial. Arch Intern Med. 2005;165(10):1167-1172. https://doi.org/10.1001/archinte.165.10.1167
  40. Vidal-Alaball J, Butler CC, Cannings-John R, et al. Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database Syst Rev. 2005;(3):CD004655. https://doi.org/10.1002/14651858.CD004655.pub2
  41. Castelli MC, Friedman K, Sherry J, et al. Comparing the efficacy and tolerability of a new daily oral vitamin B12 formulation and intermittent intramuscular vitamin B12 in normalizing low cobalamin levels: a randomized, open-label, parallel-group study. Clin Ther. 2011;33(3):358-371.e2.  https://doi.org/10.1016/j.clinthera.2011.03.003
  42. Ministry of Health of the Russian Federation. Clinical guidelines. Vitamin B12 deficiency anemia. Year of approval: 2024. ID: 536_3. https://cr.minzdrav.gov.ru/view-cr/536_3
  43. Gubonina I.V., Shchukina O.B., Stuklov N.I., et al. Anemia in inflammatory bowel diseases: the approaches to its diagnosis, treatment and prevention. Almanac of Clinical Medicine. 2019;47(8):721-732.  https://doi.org/10.18786/2072-0505-2019-47-078
  44. Duerksen DR, Fallows G, Bernstein CN. Vitamin B12 malabsorption in patients with limited ileal resection. Nutrition. 2006 Nov–Dec;22(11-12):1210-1213. https://doi.org/10.1016/j.nut.2006.08.017
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.