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Apolikhina I.A.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Tarnaeva L.A.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov

Svidzinskiy A.V.

Humboldt University of Berlin;
F.F. Institute of Public Health Erisman of the I.M. Sechenov First Moscow State Medical University

Svidzinskaya S.V.

F.F. Institute of Public Health Erisman of the I.M. Sechenov First Moscow State Medical University

Strictly on business

Authors:

Apolikhina I.A., Tarnaeva L.A., Svidzinskiy A.V., Svidzinskaya S.V.

More about the authors

Journal: Non Nocere. New Therapeutic Journal. 2025;(7): 74‑80

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To cite this article:

Apolikhina IA, Tarnaeva LA, Svidzinskiy AV, Svidzinskaya SV. Strictly on business. Non Nocere. New Therapeutic Journal. 2025;(7):74‑80. (In Russ.)

 
 
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Использование инфографики авторами научных работ
Abstract:

Biofilm vaginosis: from theory to clinical practice.

Authors:

Apolikhina I.A.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov

Tarnaeva L.A.

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov

Svidzinskiy A.V.

Humboldt University of Berlin;
F.F. Institute of Public Health Erisman of the I.M. Sechenov First Moscow State Medical University

Svidzinskaya S.V.

F.F. Institute of Public Health Erisman of the I.M. Sechenov First Moscow State Medical University

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References:

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  2. Kenyon C, Colebunders R, Crucitti T. The global epidemiology of bacterial vaginosis: a systematic review. Am J Obstet Gynecol. 2013 Dec;209(6):505-523.  https://doi.org/10.1016/j.ajog.2013.05.006
  3. Peebles K, Velloza J, Balkus JE, McClelland RS, Barnabas RV. High Global Burden and Costs of Bacterial Vaginosis: A Systematic Review and Meta-Analysis. Sex Transm Dis. 2019 May;46(5):304-311.  https://doi.org/10.1097/OLQ.0000000000000972
  4. Leitich H, Kiss H. Asymptomatic bacterial vaginosis and intermediate flora as risk factors for adverse pregnancy outcome. Best Pract Res Clin Obstet Gynaecol. 2007 Jun;21(3):375-390.  https://doi.org/10.1016/j.bpobgyn.2006.12.005
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  11. Machado A, Cerca N. Influence of Biofilm Formation by Gardnerella vaginalis and Other Anaerobes on Bacterial Vaginosis. J Infect Dis. 2015 Dec 15;212(12):1856-1861. https://doi.org/10.1093/infdis/jiv338
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  15. Swidsinski A, Loening-Baucke V. Evaluation of Polymicrobial Involvement Using Fluorescence In Situ Hybridization (FISH) in Clinical Practice. In: Liehr, T. (eds) Fluorescence In Situ Hybridization (FISH). Springer Protocols Handbooks. Springer, Berlin, Heidelberg. 2017;531-543.  https://doi.org/10.1007/978-3-662-52959-1_52
  16. Swidsinski A, Loening-Baucke V, Swidsinski S, Sobel JD, Dörffel Y, Guschin A. Clue Cells and Pseudo Clue Cells in Different Morphotypes of Bacterial Vaginosis. Front Cell Infect Microbiol. 2022 May 27;12:905739. https://doi.org/10.3389/fcimb.2022.905739
  17. Swidsinski A, Guschin A, Corsini L, et al. Antimicrobial Susceptibility of Microbiota in Bacterial Vaginosis Using Fluorescence In Situ Hybridization. Pathogens. 2022 Apr 11;11(4):456.  https://doi.org/10.3390/pathogens11040456
  18. Swidsinski A, Mendling W, Loening-Baucke V, et al. An adherent Gardnerella vaginalis biofilm persists on the vaginal epithelium after standard therapy with oral metronidazole. Am J Obstet Gynecol. 2008 Jan;198(1):97.e1-6.  https://doi.org/10.1016/j.ajog.2007.06.039
  19. Borges S, Silva J, Teixeira P. The role of lactobacilli and probiotics in maintaining vaginal health. Arch Gynecol Obstet. 2014 Mar;289(3):479-489.  https://doi.org/10.1007/s00404-013-3064-9
  20. Ma X, Wang X, Ye S, Liu J, Yuan H, Wang N. Biofilm and pathogenic factor analysis of Gardnerella vaginalis associated with bacterial vaginosis in Northeast China. Front Microbiol. 2022 Dec 22;13:1033040. https://doi.org/10.3389/fmicb.2022.1033040
  21. Qin H, Liu Y, Zhai Z, Xiao B. Biofilm-Forming Capacity and Drug Resistance of Different Gardnerella Subgroups Associated with Bacterial Vaginosis. Microorganisms. 2023 Aug 30;11(9):2186. https://doi.org/10.3390/microorganisms11092186
  22. Schwebs T, Kieninger AK, Podpera Tisakova L, et al. Evaluation of Metronidazole Resistance of Vaginal Swab Isolates from South African Women Treated for Bacterial Vaginosis. Antibiotics (Basel). 2024 Dec 14;13(12):1217. https://doi.org/10.3390/antibiotics13121217
  23. Rosca AS, Castro J, Sousa LGV, França A, Cavaleiro C, Salgueiro L, Cerca N. Six Bacterial Vaginosis-Associated Species Can Form an In Vitro and Ex Vivo Polymicrobial Biofilm That Is Susceptible to Thymbra capitata Essential Oil. Front Cell Infect Microbiol. 2022 May 4;12:824860. https://doi.org/10.3389/fcimb.2022.824860
  24. Farr A, Swidsinski S, Surbek D, et al. Bacterial Vaginosis: Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/028, June 2023). Geburtshilfe Frauenheilkd. 2023 Nov 3;83(11):1331-1349. https://doi.org/10.1055/a2169-8539
  25. Sousa LGV, Pereira SA, Cerca N. Fighting polymicrobial biofilms in bacterial vaginosis. Microb Biotechnol. 2023 Jul;16(7):1423-1437. https://doi.org/10.1111/1751-7915.14261
  26. Swidsinski A, Loening-Baucke V, Swidsinski S, Verstraelen H. Polymicrobial Gardnerella biofilm resists repeated intravaginal antiseptic treatment in a subset of women with bacterial vaginosis: a preliminary report. Arch Gynecol Obstet. 2015 Mar;291(3):605-609.  https://doi.org/10.1007/s00404-014-3484-1
  27. Bradshaw CS, Brotman RM. Making inroads into improving treatment of bacterial vaginosis – striving for long-term cure. BMC Infect Dis. 2015 Jul 29;15:292.  https://doi.org/10.1186/s12879-015-1027-4
  28. Landlinger C, Tisakova L, Oberbauer V, et al. Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo. Pathogens. 2021 Jan 8;10(1):54.  https://doi.org/10.3390/pathogens10010054
  29. Bradshaw CS, Sobel JD. Current Treatment of Bacterial Vaginosis – Limitations and Need for Innovation. J Infect Dis. 2016 Aug 15;214 Suppl 1(Suppl 1): S14-20.  https://doi.org/10.1093/infdis/jiw159
  30. Paris JL, Mannaris C, Cabañas MV, et al. Ultrasound-mediated cavitation-enhanced extravasation of mesoporous silica nanoparticles for controlled-release drug delivery. Chemical Engineering Journal. 2017;340:2-8.  https://doi.org/10.1016/J.CEJ.2017.12.051
  31. Ghasemi M, Sivaloganathan S. Effect of inertial acoustic cavitation on antibiotic efficacy in biofilms. Appl. Math. Mech.Engl. 2021;42:1397-1422. https://doi.org/10.1007/s10483-021-2776-7
  32. Bharatula LD, Marsili E, Rice SA, Kwan JJ. Influence of High Intensity Focused Ultrasound on the Microstructure and c-di-GMP Signaling of Pseudomonas aeruginosa Biofilms. Front. Microbiol. 2020;11:599407. https://doi.org/10.3389/fmicb.2020.599407
  33. Cohen CR, Wierzbicki MR, French AL, et al. Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis. N Engl J Med. 2020 May 14;382(20):1906-1915. https://doi.org/10.1056/NEJMoa1915254
  34. Huang H, Song L, Zhao W. Effects of probiotics for the treatment of bacterial vaginosis in adult women: a meta-analysis of randomized clinical trials. Arch Gynecol Obstet. 2014 Jun;289(6):1225-1234. https://doi.org/10.1007/s00404-013-3117-0
  35. Piletskaya U.V., Marinkin I.O., Makarov K.Yu., Sokolova T.M., Kiseleva T.V. Comparison of the eff ectiveness of common treatment regimens for bacterial vaginosis. Journal of Siberian Medical Sciences. 2022;6(3):117-128.  https://doi.org/10.31549/2542-1174-2022-6-3-117-128
  36. Khusnutdinova TA, Spasibova EV, Shalepo KV, et al. Characteristic effect of prednisolone in vitro administered in the form of prednisolone sodium phosphate in a combined preparation on biofilm-forming microorganisms of the vaginal biotope. Akusherstvo i Ginekologiya/Obstetrics and Gynecology. 2025;(3):189-198 (in Russian). https://doi.org/10.18565/aig.2025.81
  37. Bokach O.M., Murasheva M.S., Selkova M.S., Storozheva K.V., Chepanov S.V., Selkov S.A. An impact of the combined drug containing antimicrobial, antiprotozoal, antifungal and glucocorticoid agents on local immunity in women with bacterial vaginosis and non-specific vaginitis. Russian Journal of Infection and Immunity. 2021. Vol. 11. No. 3. P. 549-555.  https://doi.org/10.15789/2220-7619-AIO-1462
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