The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Vasileva A.A.

M.V. Lomonosov Moscow State University

Vasilyev V.A.

Institute of Gene Biology of the Russian Academy of Sciences

Okushko R.V.

Taras Shevchenko Transnistria State University

Negasheva M.A.

M.V. Lomonosov Moscow State University

Associations of catechol-O-methyl transferase gene polymorphism (COMT) with morphofunctional indicators in russian and transnistrian students

Authors:

Vasileva A.A., Vasilyev V.A., Okushko R.V., Negasheva M.A.

More about the authors

Journal: Molecular Genetics, Microbiology and Virology. 2021;39(1): 42‑49

DOI: 10.17116/molgen20213901142

Read: 2416 times

Download PDF (RU)
Contact the author
Table of contents

ASSOCIATIONS OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM (COMT) WITH MORPHOFUNCTIONAL INDICATORS IN RUSSIAN AND TRANSNISTRIAN STUDENTS
ASSOCIATIONS OF CATECHOL-O-METHYL TRANSFERASE GENE POLYMORPHISM (COMT) WITH MORPHOFUNCTIONAL INDICATORS IN RUSSIAN AND TRANSNISTRIAN STUDENTS

To cite this article:

Vasileva AA, Vasilyev VA, Okushko RV, Negasheva MA. Associations of catechol-O-methyl transferase gene polymorphism (COMT) with morphofunctional indicators in russian and transnistrian students. Molecular Genetics, Microbiology and Virology. 2021;39(1):42‑49. (In Russ.)
https://doi.org/10.17116/molgen20213901142

Подписка 2026 Молекулярная генетика, микробиология и вирусология (Molecular Genetics, Microbiology and Virology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Study of the dyna­mics of arte­rial pressure and body composition during manual physical therapy using the method of A.Yu. Shishonin. Problems of Balneology, Physiotherapy and Exercise Therapy. 2025;(3):41-45
Abstract:

A feature of human morphology, which is most often considered in connection with gene polymorphism, is excessive fat deposition. Obesity contributes to an increased risk of chronic diseases.

THE AIM OF THIS STUDY

Is to search for possible associations between the rs4680 polymorphism of the COMT gene and the morphofunctional characteristics of students in Russia and Transnistria.

MATERIALS AND METHODS

The data of genotyping (according to the COMT gene) and a comprehensive anthropological examination (18 morphological and functional indicators) of 451 volunteers aged 16—23 years were the materials for the study.

RESULTS

The study of the distribution of alleles in the examined youth sample showed the predominance of the G allele over the A allele (0.533 and 0.467, respectively), which is consistent with data from other researchers obtained from samples of Russian residents of Novosibirsk and Americans of European descent. According to the results of a multi-stage statistical analysis of anthropogenetic data, it was found that young men and women who are carriers of at least one A allele are not prone to reduced metabolic rate and increased body weight compared to holders of the G/G homozygous genotype. In turn, carriers of the G/G genotype are characterized by a deterioration in physical development: they have a lower proportion of the musculoskeletal component of body composition and a low rate of metabolic processes with increased body weight compared to individuals with the A/A or A/G genotype.

CONCLUSION

Statistically significant relationships were revealed between the the COMT gene rs4680 polymorphism and the characteristics of the males and females body composition. The results are consistent with some data from other researchers who find correlations of the G/G genotype with a predisposition to obesity and type 2 diabetes mellitus, as well as to high-fat foods intake.

Keywords:

COMT gene polymorphism
morphological and functional features
body composition
students of Russia and Transnistria

Authors:

Vasileva A.A.

M.V. Lomonosov Moscow State University

Vasilyev V.A.

Institute of Gene Biology of the Russian Academy of Sciences

Okushko R.V.

Taras Shevchenko Transnistria State University

Negasheva M.A.

M.V. Lomonosov Moscow State University

Received:

04.12.2019

Accepted:

20.08.2020

Close metadata

References:

  1. Bondarenko EA, Shadrina MI, Druzhkova TA, Akzhigitov RG, Gulyaeva NV, Gekht AB, et al. Association study of rs10462021 polymorphism in the clock gene period3 and different clinical types of depression. Molecular Genetics, Microbiology and Virology. 2018;36(1):23-25. (In Russ.). https://doi.org/10.18821/0208-0613-2018-36-1-23-25
  2. Bondareva EA, Parfenteva OI, Kozlov AV, Zhuravleva US, Kosyakova EV, Karelina EE, et al. The ala/val polymorphism of the ucp2 gene is reciprocally associated with aerobic and anaerobic performance in athletes. Hum Physiol. 2018;44(6):673-678.  https://doi.org/10.1134/S036211971806004X
  3. Bondareva EA, Parfenteva OI, Son’kin VD. «Thrifty» genotype: obesity or sports achievement? Moscow University Anthropology Bulletin. 2017;3:56-67. (In Russ.).
  4. Bieliński M, Jaracz M, Lesiewska N, Tomaszewska M, Sikora M, Junik R, et al. Association between COMT Val158Met and DAT1 polymorphisms and depressive symptoms in the obese population. Neuropsychiatr Dis Treat. 2017;13:2221-2229. https://doi.org/10.2147/NDT.S138565
  5. Swinburn BA, Sacks G, Hall KD, McPherson K, Finegood DT, Moodie ML, et al. The global obesity pandemic: shaped by global drivers and local environments. The Lancet. 2011;378(9793):804-814.  https://doi.org/10.1016/S0140-6736(11)60813-1
  6. Muc M, Padez C, Manco L. Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults. Am J Hum Biol. 2015;27(5):734-738.  https://doi.org/10.1002/ajhb.22712
  7. Dixon JB, Dixon ME, O’Brien PE. Depression in association with severe obesity: changes with weight loss. Arch Inter Med. 2003;163(17):2058-2065. https://doi.org/10.1001/archinte.163.17.2058
  8. Bruffaerts R, Demyttenaere K, Vilagut G, Martinez M, Bonnewyn A, De Graaf R, et al. The relation between body mass index, mental health, and functional disability: a European population perspective. Can J Psychiatry. 2008;3(10):679-688.  https://doi.org/10.1177/070674370805301007
  9. Holton S, Fisher J, Nguyen H, Brown WJ, Tran T. Pre-pregnancy body mass index and the risk of antenatal depression and anxiety. Women and Birth. 2019;32(6):508-514.  https://doi.org/10.1016/j.wombi.2019.01.007
  10. Stein DJ, Newman TK, Savitz J, Ramesar R. Warriors versus worriers: the role of COMT gene variants. CNS spectrums. 2006;11(10):745-748.  https://doi.org/10.1017/s1092852900014863
  11. Lee LO, Prescott CA. Association of the Catechol-O-Methyltransferase (COMT) Val158Met polymorphism and anxiety-related traits: a meta-analysis. Psychiatr Genet. 2014;24(2):52-69.  https://doi.org/10.1097/YPG.0000000000000018
  12. Massat I, Souery D, Del-Favero J, Nothen M, Blackwood D, Muir W, et al. Association between COMT (Val 158 Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study. Mol Psychiatry. 2005;10(6):598-605.  https://doi.org/10.1038/sj.mp.4001615
  13. Annerbrink K, Westberg L, Nilsson S, Rosmond R, Holm G, Eriksson E. Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men. Metabolism. 2008;57(5):708-711.  https://doi.org/10.1016/j.metabol.2008.01.012
  14. Solntsava AV, Zagrebaeva OY, Aksenova EA, Shatarnova TM, Emelyantsava TA, Dashkevich EI. Polymorphism genes COMT, MAOA, 5-HTTLPR locus SLC6A4 and morbid obesity in children. Med J. 2016;2:112-115. (In Russ.).
  15. Galvão AC, Krüger RC, Campagnolo PD, Mattevi VS, Vitolo MR, Almeida S. Association of MAOA and COMT gene polymorphisms with palatable food intake in children. J Nutr Biochem. 2012;23(3):272-277.  https://doi.org/10.1016/j.jnutbio.2010.12.004
  16. Kring SI, Werge T, Holst C, Toubro S, Astrup A, Hansen T, et al. Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes. PLoS One. 2009;4(8):e6696. https://doi.org/10.1371/journal.pone.0006696
  17. Thaler L, Groleau P, Badawi G, Sycz L, Zeramdini N, Too A, et al. Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating-and personality-related psychopathology. Prog Neuropsychopharmacol Biol Psychiatry. 2012;39(1):120-128.  https://doi.org/10.1016/j.pnpbp.2012.05.019
  18. Rudnev SG, Anisimova AV, Sindeeva LV, Zadorozhnaya LV, Lukina SS, Malakhina AV, et al. Methodological issues of studying variations in subcutaneous fat: a comparison of different types of skinfold calipers. Moscow University Anthropology Bulletin. 2017;3:4-26. (In Russ.).
  19. Nikolaev DV, Smirnov AV, Bobrinskaya IG, Rudnev SG. Bioimpedansnyj analiz sostava tela cheloveka. M.: Nauka; 2009. (In Russ.).
  20. Afifi A, Ejzen S. Statisticheskij analiz. Podhod s ispol’zovaniem EVM. M.: Mir; 1982. (In Russ.).
  21. Dubrovskij SA. Prikladnoj mnogomernyj statisticheskij analiz. M.: Finansy i statistika; 1982. (In Russ.).
  22. Kim DO, M’yuller CU, Klekka UR, Oldenderfer MS, Bleshfild RK. Faktornyj, diskriminantnyj i klasternyj analiz. M.: Finansy and statistika; 1989. (In Russ.).
  23. Kuznetsov EA, Negasheva MA, Anohin VN, Volov NA, Li ED, Bychkova OP. A mathematical model of diagnosing coronary heart disease by means of multiple discriminate analysis. Russian Journal of Cardiology. 2001;5:60-65. (In Russ.). https://doi.org/10.15829/1560-4071-2001-5-60-65
  24. Potekaev NN, Negasheva ES, Zhukova OV, Frigo NV, Negasheva MA, Dmitriev GA, et al. The use of multidimensional discriminant analysis in the diagnosis of neurosyphilis. Russian J Clinical Dermatology and Venereology. 2019;18(1):18-26. (In Russ.). https://doi.org/10.17116/klinderma20191801118
  25. Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A, Huddleston J, et al. An integrated map of structural variation in 2,504 human genomes. Nature. 2015;526(7571):75-81.  https://doi.org/10.1038/nature15394
  26. Triska P, Chekanov N, Stepanov V, Khusnutdinova EK, Kumar GPA, Akhmetova V, et al. Between Lake Baikal and the Baltic Sea: genomic history of the gateway to Europe. BMC Genet. 2017;18(1):110.  https://doi.org/10.1186/s12863-017-0578-3
  27. Negasheva MA, Zimina SN, Sineva IM, Yudina AM. Morphofunctional adaptation of young students living in different cities of Russia. Moscow University Anthropology Bulletin. 2018;3:41-54. (In Russ.). https://doi.org/10.32521/2074-8132.2018.3.041-054
  28. Davis C, Patte K, Levitan R, Reid C, Tweed S, Curtis C, From motivation to behaviour: a model of reward sensitivity, overeating, and food preferences in the risk profile for obesity. Appetite. 2007;48:12-19.  https://doi.org/10.1016/j.appet.2006.05.016
  29. Avsar O, Kuskucu A, Sancak S, Genc E. Are dopaminergic genotypes risk factors for eating behavior and obesity in adults? Neurosci Lett. 2017;654:28-32.  https://doi.org/10.1016/j.neulet.2017.06.023
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.