mRNP transport in eukaryotes. mRNP export from the nucleus

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To translation, the newly synthesized mRNA undergoes several stages of maturation; and the proteins involved in these processes, form mRNP particle. After the stage of maturation mRNA is exported from the nucleus to the cytoplasm and transported to the ribosome, where the process of translating mRNA into protein occurs. Recruiting the factors of mRNA export and transport to the newly synthesized mRNA occurs partly cotranscriptionally. Many of the proteins associate with mRNA from the first stages of transcription to its localization in the cytoplasm. Other factors perform their functions strictly at a certain stage. During all stages of the mRNA export the composition of proteins, which are required for accession to the nuclear pore and the passage through it, and also for delivery to the sites of localization in the cytoplasm, is changing. In this article, we describe the main participants in the export of the mRNA particle, beginning from its delivery to the nuclear pore, attaching it to the nuclear pore and translocating through it.

Keywords:

mRNP particle

mRNA

NPC

nuclear export receptor

remodeling mRNK

Authors:

Glukhova A.A.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia

Nabirochkina E.N.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia

Kopytova D.V.

Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334 Russia

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