Thrombotic and hemorrhagic complications are a frequent event and the main cause of death of patients with chronic myeloproliferative neoplasms (MPN). The somatic mutations in the genes JAK2, MPL, CALR are determining the pathogenesis of MPN and associated with individual phenotypic manifestations of the disease: polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). Recent studies have also demonstrated the role of integrin and collagen receptors in regulating the proliferative activity of proplatelet and the formation of bone marrow fibrosis. The role of polymorphisms of hereditary thrombophilia in the pathogenesis of MPN has not been extensively studied. The aim of the study was to determine the prognostic significance of carriage of genetic polymorphisms of platelet receptors on the development of some variants of MPN. Material and methods. 160 patients with MPN, were analyzed for thrombotic polymorphisms in genes encoding the components of plasma and platelet hemostasis: FII, FV, MTHFR, ITGB3, GPIBA, ITGA2, P2RY12 and the SELPIG gene. Results. The frequency of the studied polymorphisms in the general group of patients with MPN suggest to the data in the control group and in the European population. It was shown that the polymorphism of the vWF receptor is more frequent in the ET group than in the PV group. Polymorphism of the SELPLG was more common in the MF group than in patients with PV. Conclusions. Genetic features of individual receptor structures of cells of the megakaryocytic line can determine the features of phenotypic manifestations of MPN.