Background. Trichophyton indotineae appeared as a new type of dermatophytes causing treatment-resistant skin infections. The first mentions of T. indotineae came from India. Currently, the causative agent has spread in many parts of the world and is rapidly becoming a global healthcare problem. The precise identification of T. indotineae requires complex mycological examinations that transcend routine microbiological testing.

MATERIAL AND METHODS

Routine laboratory methods, namely KOH microscopy, mycological culture, as well as molecular biological investigation methods were used for the diagnosis of dermatomycoses and species-level identification of fungi.

RESULTS AND CONCLUSIONS

The appearance and prevalence of T. indotineae has significantly changed the classical approach to the management of patients with dermatomycosis worldwide. Two clinical observations, namely the first in the Russian Federation description of the skin lesions with genetic confirmation of the causative agent’s belonging to T. indotineae species and its resistant mutation to allylamines — Phe397Leu in the gene encoding squalene epoxidase, have been presented.

Patients had a long-term (more than 2 years) pathological process that did not respond to therapy with various options of standard treatment regimens by both topical and systemic drugs.

Further development of molecular diagnosis with species-level identification of T. indotineae and detection of mutations in SQLE should be one of the priority directions in domestic medical mycology, considering the increasing prevalence of resistant strains worldwide.