Aging is multilevel and multicomponent process. Total result of changes taking place is manifested by deterioration of epithelial tissues quality, change of facial expression and face shape in clinical picture of aging. Despite the fact that age-related changes occur regularly in all people, individual features of anatomical structures make each person unique. The changes taking place can be more pronounced and prevalent in one or few tissue layers or distributed relatively equally at all levels. This process is caused by anatomical constitutional features of tissues and determines various clinical patients’ portraits that, in turn, requires a differential approach with the implementation of different aesthetic correction tasks. There is a wide range of hardware and injection methods that allow to achieve synergistic effect with more pronounced results. Combined protocols of collagen synthesis stimulation with the use of physical factor and implantable material are in the focus of attention as a possibility of strengthening the intensity and duration of preservation of aesthetic results made by minimally invasive non-surgical methods. Personalization of the protocols according to the patients’ portrait and anatomical constitutional features of structural facial tissues allows to fully implement the potential of each factor and their synergistic effect, preventing adverse events in different aging morphotypes.