Immunogenetic criteria for prediction of severe leprotic polyneuritis course

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OBJECTIVE

To identify genetic markers related to the development of leprotic polyneuropathy.

MATERIAL AND METHODS

A number of patients equal 42 with multibacterial leprosy of the Russian population sample of residents of the Astrakhan endemic leprosy region were examined, including 21 patients with severe polyneuritis and 21 with sensitive disorders of the peripheral nervous system. HLA-genotyping on the alleles of the DRB1, DQA1 and DQB1 loci was carried out by PCR using HLA-DNA-Tech sets. The frequency distribution of haplotypes was determined based on the ratio of the number of individuals «carrying» this allele or haplotype to the total number of individuals in the sample.

RESULTS

More than two-fold (2.4) increase in frequency of HLA-DRB1*15-DQA1*0102-DQB1*0602/08 haplotype occurrence in patients suffering from leprosy with a severe leprotic polyneuritis (II degree of disability according to WHO) was established, which was 0.571 compared to patients with sensitive disorders of the peripheral nervous system (0.238) (p<0.05).

CONCLUSION

The use of the immunogenetic marker in the form of the presence in the patient’s genotype of the HLA-DRB1*15-DQA1*0102-DQB1*0602/08 haplotype makes it possible to predict the development of the severe course of leprotic polyneuritis both at the beginning of the disease and in its long-term period.

Keywords:

leprosy

polyneuritis

HLA-genotyping

haplotypes

disability

Authors:

L.V. Saroyants

Astrakhan State Medical University;
Astrakhan State University named after V.N. Tatishchev

ORCID: 0000-0002-4426-3860

V.Z. Naumov

Astrakhan State Medical University

A.V. Naumov

Astrakhan State Medical University

ORCID: 0000-0001-7874-7057

Received:

06.07.2023

Accepted:

16.11.2023

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