Two cases of skin T-cell lymphoma were presented. They simulated chronic dermatoses with numerous recurrent skin rashes for several years and were not diagnosed in the early stages. Patients were initially diagnosed with allergic contact dermatitis, irritant contact dermatitis, erythema nodosum, skin sarcoidosis, psoriasis, carbuncle, and chronic ulcerative pyoderma and treated with antihistamines, glucocorticoids, antibiotics, and topical agents. In both cases, in the initial stages, patients had a slowly progressive course of dermatoses with periods of exacerbations and remissions. The rapid progression of diseases with a tendency to the skin process generalization, nodular rashes, and the lack of response to therapy occurred shortly after the coronavirus infection. Patients had skin biopsies followed by a pathological and immunohistochemical examination. The clinical examination, medical history, and pathological pattern confirmed the tumor stage of skin lymphoma. For further management, patients were referred to an oncologist.