Regulation of elastin turnover in the skin: Biological and genetic aspects

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Elastin is a key component of elastic fibers that make up the fibrous substance of the skin’s extracellular matrix. Currently, the skin extracellular matrix is known to have the supporting function and many others, such as participation in proliferation, cell migration, etc. Thus, elastic fibers play a mechanical and regulatory role in the skin, which is most clearly demonstrated by the functions of elastin peptides studied. However, it should be noted that the turnover of elastic fibers has specific features in comparison with that of other extracellular matrix components. Thus, the half-life of elastic fibers is much longer than that of collagen fibers and hyaluronic acid; elastic fibers are more resistant to the peptidases cleavage under physiological conditions, and the expression of the elastin gene is minimal in the mature period. Unfortunately, the papers on the methods of esthetic correction of age-related facial skin change rarely dwell on the peculiarities of turnover of skin extracellular matrix components. The objective of this review is to address the biological and genetic aspects of elastic fiber turnover in the skin.

Keywords:

elastin

elastic fibers

elastin turnover

degradation of elastic fibers

Authors:

Borzykh O.B.

Voyno-Yasenetsky Krasnoyarsk State Medical University (V.F. Voyno-Yasenetsky KrasSMU)

Shnayder N.A.

Bekhterev National Medical Research Center of Psychiatry and Neurology

Petrova M.M.

Voino-Yasenetsky Krasnoyarsk State Medical University

Karpova E.I.

Pirogov Russian National Research Medical University

Demina O.M.

Pirogov Russian National Research Medical University (RNRMU)

Zatolokina M.A.

Kursk state medical university

Received:

01.10.2021

Accepted:

25.05.2022

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