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Sorokina E.V.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Vladimirova E.V.

Academy of postgraduate education under Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

Akhmatova N.K.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Medical Institute of Penza State University

Markova Yu.A.

Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Differential diagnosis of granulomatous dermatoses without proven infectious agents

Authors:

Sorokina E.V., Vladimirova E.V., Akhmatova N.K., Markova Yu.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2021;20(6): 19‑29

DOI: 10.17116/klinderma20212006119

Views: 12263

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Table of contents

DIFFERENTIAL DIAGNOSIS OF GRANULOMATOUS DERMATOSES WITHOUT PROVEN INFECTIOUS AGENTS
DIFFERENTIAL DIAGNOSIS OF GRANULOMATOUS DERMATOSES WITHOUT PROVEN INFECTIOUS AGENTS

To cite this article:

Sorokina EV, Vladimirova EV, Akhmatova NK, Markova YuA. Differential diagnosis of granulomatous dermatoses without proven infectious agents. Russian Journal of Clinical Dermatology and Venereology. 2021;20(6):19‑29. (In Russ.)
https://doi.org/10.17116/klinderma20212006119

Подписка 2025-2 (Russian Journal of Clinical Dermatology and Venereology)
 
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Granulomatous dermatoses represent a wide range of etiologically and clinically different skin diseases. Although the pathogenesis of these diseases is not fully understood it is believed that this mechanism is based on a reaction caused by an immunogenic stimulus. Antigen-presenting cells and the effects of various cytokines play a key role in it. Traditionally, a distinction is made between infectious and non-infectious granulomatous dermatoses. The article discusses granulomatous dermatoses with unproven infections’ etiology/pathogenesis. Granulomatous dermatoses that belong to systemic diseases, include sarcoidosis, Blau’s syndrome, Crohn’s disease and chronic granulomatous disease. Localized granulomatous dermatoses include Melkersson-Rosenthal syndrome, granulomatous rosacea subtype, granulomatous type of perioral dermatitis, granulomatous pigmentary purpurous dermatosis. Reactive conditions that may be associated with systemic diseases include granuloma annulare, rheumatoid nodules, necrobiosis lipoidosis, necrobiotic xanthogranuloma, and palisade neutrophilic and granulomatous dermatitis. Skin granulomatous reactions can be associated with endocrinopathies including scleromyxedema, pretibial myxedema, diabetic blisters and systemic amyloidosis. Granulomatous dermatoses may be part of various systemic disorders or may be associated with them.

Keywords:

granulomatous dermatoses
annular granuloma
lipoid necrobiosis
granulomatous rosacea
granulomatous perioral dermatitis
Melkersson-Rosenthal syndrome
granulomatous purpureous pigmented dermatosis
necrobiotic xanthogranuloma
interstitial granuloma

Authors:

Sorokina E.V.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Vladimirova E.V.

Academy of postgraduate education under Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of Russia

Akhmatova N.K.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Medical Institute of Penza State University

Markova Yu.A.

Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Received:

18.02.2021

Accepted:

31.08.2021

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