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Sorokina E.V.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Sivakova N.G.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences

Akhmatova N.K.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Medical Institute of Penza State University

Skhodova S.A.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences

Effects of innate immunity in chronic spontaneous urticaria

Authors:

Sorokina E.V., Sivakova N.G., Akhmatova N.K., Skhodova S.A.

More about the authors

Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(3): 337‑342

DOI: 10.17116/klinderma202019031337

Read: 2133 times

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Table of contents

EFFECTS OF INNATE IMMUNITY IN CHRONIC SPONTANEOUS URTICARIA
EFFECTS OF INNATE IMMUNITY IN CHRONIC SPONTANEOUS URTICARIA

To cite this article:

Sorokina EV, Sivakova NG, Akhmatova NK, Skhodova SA. Effects of innate immunity in chronic spontaneous urticaria. Russian Journal of Clinical Dermatology and Venereology. 2020;19(3):337‑342. (In Russ.)
https://doi.org/10.17116/klinderma202019031337

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE PURPOSE OF THE STUDY

Was to investigate the expression pattern of toll-like receptors, the immunophenotype of lymphocytes, the cytokine profile of patients with chronic spontaneous urticaria (CSU).

MATERIAL AND METHODS

In 134 patients with CSU, TLR expression 2, 3, 4, 9 was studied on mononuclear leukocytes of peripheral blood (MLPB) using monoclonal antibodies («Caltag Laboratories», USA) using an FC-500 flow cytometer («Beckman Culter», USA). The immunophenotype of lymphocytes (CD3+/CD45+, CD3+/CD4+, CD3+/CD8+, CD16+/CD56+, CD45+/CD25+, CD72+, CD45+/CD95+) was studied by flow cytometry method. The cytokine profile (IFN-γ, IL 1β, 2, 4, 5, 10) of serum/plasma of blood was studied by enzyme-linked immunosorbent assay method.

RESULTS

In patients with CSU were revealed, low expression levels of TLR 2, 3, 4, 9, a decrease in the content of CD3/CD45, CD3/CD4, an increase in the level of CD45/CD25, CD45/CD95 on lymphocytes, an increased production of pro-inflammatory IL-1β, anti-inflammatory IL 4 and 5 against normal levels of production of IL 2, 10 and IFN-γ.

CONCLUSIONS

A decrease in the number of MLPB expressing TLRs 2 and 4 indicates a possible relationship between innate immunity and the etiopathogenesis of CSU. An increase in the expression of IL-4 in serum indicates the activation of T-lymphocytes by the Th2 pathway in patients with CSU.

Keywords:

chronic spontaneous urticaria
toll-like receptors
innate immunity

Authors:

Sorokina E.V.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Department of skin and venereal diseases with cosmetology course Federal state budgetary educational institution of additional professional education Institute of advanced training of Federal medical and biological Agency

Sivakova N.G.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences

Akhmatova N.K.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences;
Medical Institute of Penza State University

Skhodova S.A.

I.I. Mechnikov Research Institute of Vaccines and Serums, Russian Academy of Medical Sciences

Received:

21.06.2019

Accepted:

07.04.2020

Close metadata

References:

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