Optimization of diagnostics and treatment of patients with onychomycosis of feet against the background of non-alcoholic fatty liver disease

Khismatullina Z.R.; Vlasova N.A.; Rustamkhanova G.R.

doi:https://doi.org/10.17116/klinderma20201901136

Khismatullina Z.R.

Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, Russia, 450000

Vlasova N.A.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Rustamkhanova G.R.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Optimization of diagnostics and treatment of patients with onychomycosis of feet against the background of non-alcoholic fatty liver disease

Authors:

Khismatullina Z.R., Vlasova N.A., Rustamkhanova G.R.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2020;19(1): 36‑42

DOI: 10.17116/klinderma20201901136

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To cite this article:

Khismatullina ZR, Vlasova NA, Rustamkhanova GR. Optimization of diagnostics and treatment of patients with onychomycosis of feet against the background of non-alcoholic fatty liver disease. Russian Journal of Clinical Dermatology and Venereology. 2020;19(1):36‑42. (In Russ.)
https://doi.org/10.17116/klinderma20201901136

Подписка 2026 Клиническая дерматология и венерология (Russian Journal of Clinical Dermatology and Venereology)

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Abstract:

Relevance. The problem of onychomycosis treatment is still topical, especially in persons with somatic pathology, in particular with non-alcoholic fatty liver disease (NAFLD). The aim of the study is to optimize the diagnosis and treatment of onychomycosis of the feet based on the assessment of the metabolic activity of intestinal microflora in patients with NAFLD at the stage of fatty hepatosis. Materials and methods. Studies have been carried out in patients with onychomycosis of the feet with NAFLD at the stage of fatty hepatosis in order to study the functional state of the liver, the frequency and nature of intestinal microflora disorders in the course of complex therapy (antimicrotic drug terbinafine in combination with prebiotic). The results. In the process of complex antimicrotic therapy with the preparation of terbinafine in patients with onychomycosis of the feet with NAFLD at the stage of fatty hepatosis no increase in the markers of cytolysis and cholestasis has been registered. Disturbances of intestinal microbiocenosis in the form of II-III degree dysbiosis were revealed in 93% of patients, which were successfully corrected by taking prebiotic drug, which led to the restoration of quantitative and qualitative composition of intestinal microflora, improved detoxification function of the liver, increased efficiency of therapy and reduced number of relapses. Conclusion. The high efficacy and safety of the complex antimicrotic therapy with the preparation of terbinafine in combination with prebiotic in patients with onychomycosis of feet with NAFLD at the stage of fatty hepatosis has been shown.

Keywords:

onychomycosis

NAFLD

systemic antimicrotics

prebiotic

terbinafine

Authors:

Khismatullina Z.R.

Bashkir State Medical University, Ministry of Health of the Russian Federation, Ufa, Russia, 450000

Vlasova N.A.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

Rustamkhanova G.R.

Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russia

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