Aim. The aim of this study to evaluate the correlation between the clinical efficiency of treatment (CET) according to PASI (psoriasis area and severity index), the quality of life (QOL) according DLQI (dermatological life quality index) and the age, sex and duration of disease among the patients with a plaque form and moderate severity psoriasis. Material and methods. The 132 patients with psoriasis of plaque form of moderate severity were studied, who were divided into 2 groups. Group I includes 65 patients from 18 to 64 years old receiving the traditional terapy (detoxification, antioxidant, antihistamine, membrane-stabilizing, immunosuppressant, multivitamin, topical anti-inflammatory therapy; the duration of treatment — 1 month). Group II includes 67 patients from 18 to 69 years old receiving alternative treatment (at the same time with traditional therapy, the hepatoprotectors is also used). The control group makes 18 practically healthy people from 19 to 57 years old. Patients of group I and group II both were divided into 3 subgroups according to age, sex and duration of disease: by age (1st subgroup — up to 45, 2nd subgroup — over 45), by sex (1st subgroup — male patients, 2nd subgroup — female patients) and by the disease duration (1st subgroup — up to 10 years, 2nd subgroup — more than 10 years). To evaluate the effectiveness of treatment of psoriasis, the PASI is used. To evaluate the health-related QOL of patients with psoriasis — the DLQI is used. For each group of patients the correlation between the CET of psoriasis (according to PASI), the QOL (according DLQI) and patient’s age, sex, and duration of disease has been studied. The statistical package SPSS 16.0 was used to perform statistical analysis of data. In particular, the Student’s t-test for independent samples was applied, at that as the test uses a bit different formulas for the cases depending on whether the variances of compared groups are statistically different or not, first the Levene’s test was applied to test variances equality (using F-statistics from Fisher’s distribution). Besides confidence-interval approach was used to test the null hypothesis (means are statistically equal). Significance level considered p≤0,05. Results. In the 1st subgroup of the patients of group I (in patients under 45 years old), the QOL (according to DLQI) is higher. In the 2nd subgroup of the patients of group II (in male patients), the QOL (according to DLQI) is higher. In the 2nd subgroup of the patients of group II (in patients under 45 years old), the CET (according to PASI) is higher. In the 3rd subgroup of the patients of group II (in patients with duration of disease up to 10 years), the CET (according to PASI) is higher. No significant changes were found in the remaining subgroups. Conclusions. According to DLQI, the correlation in 1st subgroup of patients of group I (the QOL is higher in patients under 45 years old) and in 2nd subgroup of patients of group II (the QOL according to DLQI is higher in male patients) was registered. According to PASI, the correlation in 2nd subgroup of patients of group II (the CET is higher in patients under 45 years old) and in 3rd subgroup of patients of group II (the CET is higher in patients with duration of disease up to 10 years) was registered. Thus, the recorded changes indicate that the QOL of patients is higher among young age period (in I and II groups), in male patients (in II group), and the CET is also higher among patients of young age period and in patients with duration of disease less than 10 years (in II group).