The analysis of the morbidity of socially significant infections in the conditions of increased migration of the population and the timeliness of their detection among foreign citizens and stateless persons seems to be relevant. Objective — to study the frequency of detection of socially significant diseases, including syphilis, HIV infection and tuberculosis, in foreign citizens and stateless persons who arrived in Moscow. Material and methods. The forms 089u/kv, registers of syphilis, HIV and tuberculosis incidence among foreign citizens and stateless persons for the period from 2013 to 2018 were used. Mathematical, analytical and descriptive methods of statistical analysis were used. Results. During the period from 2013 to 2018, the number of examinations of foreign citizens in medical organizations of the Moscow Health Department increased 13 times, while in non-governmental medical organizations it decreased 6.6 times. During the period under review, the number of cases of syphilis detected among migrants in medical institutions of the Moscow Health Department increased by 28.7 times, while the number of cases of HIV infection increased by 12.4 times, and the number of cases of tuberculosis by 4.6 times. The increase in the detection rate of these infections is due to the creation of an effective system in Moscow to combat their spread — the Multifunctional Migration Center. Conclusion. The results of the analysis indicate the need to study the frequency of detection of socially significant diseases among migrants and stateless persons in order to preserve the social well-being of society and to make timely organizational decisions.