Microsporia of skin and scalp is one of the most common clinical forms of ringworm in the Russian Federation. The main sources of microsporia infection are cats and dogs, less often rabbits, small rodents and goats. It is presented rare case report (perhaps, the first one) of a 32-year-old man infection with microsporia from an Indian elephant on Phuket Island in Southeast Asia. Microsporum canis as the most common cause of microsporia resulted skin mycosis in this case. The course of microsporia was characterized by a large number of pustules. Molecular genetic analysis of M. canis isolated from the patient confirmed identity of its genotype with the genotypes of local strains of M. canis. Those strains were previously isolated from people who were infected by cats in the North-West region, St. Petersburg and Leningrad region. Therapy with sertaconazole and griseofulvin was highly effective. Currently, wide range of topical antifungal drugs is available. Therapy with sertaconazole is very effective for microsporia due to unique structure of the active molecule followed by fungicidal effect and wide spectrum of action on the most of pathogens of skin mycoses.