Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests

Frigo N.V.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

ORCID: 0000-0001-6231-971X

Zhukova O.V.

I.M. Sechenov Moscow Medical Academy

ORCID: 0000-0001-5723-6573

Ptashinskiĭ R.I.

Moskovskiĭ nauchno-prakticheskiĭ tsentr dermatovenerologii i kosmetologii Departamenta zdravookhraneniia Moskvy, Moskva, Rossiia, 119071

Negasheva E.S.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests

Authors:

Frigo N.V., Zhukova O.V., Ptashinskiĭ R.I., Negasheva E.S.

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Journal: Russian Journal of Clinical Dermatology and Venereology. 2016;15(1): 60‑68

DOI: 10.17116/klinderma201615160-68

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To cite this article:

Frigo NV, Zhukova OV, Ptashinskiĭ RI, Negasheva ES. Issues of serological diagnosis of syphilis. Interpretation of the results of serological tests. Russian Journal of Clinical Dermatology and Venereology. 2016;15(1):60‑68. (In Russ.)
https://doi.org/10.17116/klinderma201615160-68

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Serological diagnosis of syphilis is currently the most popular method and includes a wide range of diagnostic techniques. However, the use of these methods raises a number of problems, often bewildering dermatologists. They can be divided into the following three main groups: diagnostic errors at various stages of the investigation; false-positive or biological false-positive reactions; mismatching of the results of individual studies. The article addresses the issues related to the existing problems of serological diagnosis of syphilis; provides the variants of combinations of non-treponemal and treponemal tests, provides the analysis of some clinical situations in the diagnosis of syphilis by ELISA and microprecipitation reaction, which are most commonly used in routine serological practice.

Keywords:

syphilis

serological tests

non-treponemal and treponemal tests

treponema-specific M and G immunoglobulins

Authors:

Frigo N.V.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

ORCID: 0000-0001-6231-971X

Zhukova O.V.

I.M. Sechenov Moscow Medical Academy

ORCID: 0000-0001-5723-6573

Ptashinskiĭ R.I.

Moskovskiĭ nauchno-prakticheskiĭ tsentr dermatovenerologii i kosmetologii Departamenta zdravookhraneniia Moskvy, Moskva, Rossiia, 119071

Negasheva E.S.

Moscow Sientific and Practical Center of Dermatovenereology and Cosmetology, Moscow, Russia, 119071

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