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Tsukanov A.V.

Kursk State Medical University

Ivanov I.S.

Kursk State Medical University

Ponomareva I.V.

Kursk State Medical University

Tarabrin D.V.

Kursk State Medical University

Panarina N.V.

Kursk State Medical University

Bushueva O.Yu.

Kursk State Medical University

Genetic architecture of anterior abdominal wall hernias

Authors:

Tsukanov A.V., Ivanov I.S., Ponomareva I.V., Tarabrin D.V., Panarina N.V., Bushueva O.Yu.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(8): 118‑124

DOI: 10.17116/hirurgia2024081118

Views: 358

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Table of contents

To cite this article:

Tsukanov AV, Ivanov IS, Ponomareva IV, Tarabrin DV, Panarina NV, Bushueva OYu. Genetic architecture of anterior abdominal wall hernias. Pirogov Russian Journal of Surgery. 2024;(8):118‑124. (In Russ.)
https://doi.org/10.17116/hirurgia2024081118

Подписка 2025 (Pirogov Russian Journal of Surgery)
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OBJECTIVE

To analyze genome-wide studies devoted to polymorphisms of factors of anterior abdominal wall hernias, to study the association of the most common polymorphism In Russian population.

MATERIAL AND METHODS

Searching for literature data was carried out in the RSCI and PubMed databases. We enrolled national and foreign reports. The study on Russian population included 577 people.

RESULTS

We found 5 genome-wide studies performed by foreign authors. We identified the loci responsible for genetic predisposition to inguinal hernias: WT1, EFEMP1, EBF2 and ADAMTS6. The Japanese scientists revealed an important role of loci TGFB2, RNA5SP214/VGLL2, LOC646588, HMCN2, ATP5F1CP1/CDKN3. In other studies, loci 1q41 (ZC3H11B), 2p16.1 (EFEMP1), 6p22.1 (MHC region), 7q33 (CALD1) and 11p13 (WT1) determined different hernias. The EFEMP1 gene polymorphism was among genes most associated with anterior abdominal wall hernias in all studies. Analysis of this polymorphism In Russian population revealed significant association with anterior abdominal wall hernias.

CONCLUSION

The obtained data on target correction of DNA chains can significantly reduce the incidence of anterior abdominal wall hernias. In turn, this will significantly reduce the cost of surgical treatment and risk of complications with recurrences of hernias. Moreover, identifying the most associated polymorphisms may be valuable to determine the most appropriate surgical treatment.

Keywords:

polygenic architecture
anterior abdominal wall hernia
genome-wide association study (GWAS)
EFEMP1

Authors:

Tsukanov A.V.

Kursk State Medical University

Ivanov I.S.

Kursk State Medical University

Ponomareva I.V.

Kursk State Medical University

Tarabrin D.V.

Kursk State Medical University

Panarina N.V.

Kursk State Medical University

Bushueva O.Yu.

Kursk State Medical University

Received:

03.12.2023

Accepted:

20.01.2024

List of references:

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  2. Kazangapov RS, Kairkhanov EK, Imangazinov SB, Omarov NB. Prevention and treatment of wound complications with hernioplasty of postoperative ventral hernias. Medical Journal Astana. 2020;3(105):164-169. (In Russ.).
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  12. Mitura K, Śmietański M, Kozieł S, Garnysz K, Michałek I. Factors influencing inguinal hernia symptoms and preoperative evaluation of symptoms by patients: results of a prospective study including 1647 patients. Hernia. 2018;22(4):585-591.  https://doi.org/10.1007/s10029-018-1774-4
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