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Tsukanov A.V.

Kursk State Medical University

Ivanov I.S.

Kursk State Medical University

Ponomareva I.V.

Kursk State Medical University

Tarabrin D.V.

Kursk State Medical University

Panarina N.V.

Kursk State Medical University

Bushueva O.Yu.

Kursk State Medical University

Genetic architecture of anterior abdominal wall hernias

Authors:

Tsukanov A.V., Ivanov I.S., Ponomareva I.V., Tarabrin D.V., Panarina N.V., Bushueva O.Yu.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(8): 118‑124

DOI: 10.17116/hirurgia2024081118

Read: 1023 times

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Table of contents

GENETIC ARCHITECTURE OF ANTERIOR ABDOMINAL WALL HERNIAS
GENETIC ARCHITECTURE OF ANTERIOR ABDOMINAL WALL HERNIAS

To cite this article:

Tsukanov AV, Ivanov IS, Ponomareva IV, Tarabrin DV, Panarina NV, Bushueva OYu. Genetic architecture of anterior abdominal wall hernias. Pirogov Russian Journal of Surgery. 2024;(8):118‑124. (In Russ.)
https://doi.org/10.17116/hirurgia2024081118

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Recommended articles:
Connective tissue defi­ciency in the pathogenesis of ante­rior abdo­minal wall hernias and modern diagnostic approaches to improve hernioplasty outcomes. Russian Journal of Evidence-Based Gastroenterology. 2025;(3):86-94
Abstract:

OBJECTIVE

To analyze genome-wide studies devoted to polymorphisms of factors of anterior abdominal wall hernias, to study the association of the most common polymorphism In Russian population.

MATERIAL AND METHODS

Searching for literature data was carried out in the RSCI and PubMed databases. We enrolled national and foreign reports. The study on Russian population included 577 people.

RESULTS

We found 5 genome-wide studies performed by foreign authors. We identified the loci responsible for genetic predisposition to inguinal hernias: WT1, EFEMP1, EBF2 and ADAMTS6. The Japanese scientists revealed an important role of loci TGFB2, RNA5SP214/VGLL2, LOC646588, HMCN2, ATP5F1CP1/CDKN3. In other studies, loci 1q41 (ZC3H11B), 2p16.1 (EFEMP1), 6p22.1 (MHC region), 7q33 (CALD1) and 11p13 (WT1) determined different hernias. The EFEMP1 gene polymorphism was among genes most associated with anterior abdominal wall hernias in all studies. Analysis of this polymorphism In Russian population revealed significant association with anterior abdominal wall hernias.

CONCLUSION

The obtained data on target correction of DNA chains can significantly reduce the incidence of anterior abdominal wall hernias. In turn, this will significantly reduce the cost of surgical treatment and risk of complications with recurrences of hernias. Moreover, identifying the most associated polymorphisms may be valuable to determine the most appropriate surgical treatment.

Keywords:

polygenic architecture
anterior abdominal wall hernia
genome-wide association study (GWAS)
EFEMP1

Authors:

Tsukanov A.V.

Kursk State Medical University

Ivanov I.S.

Kursk State Medical University

Ponomareva I.V.

Kursk State Medical University

Tarabrin D.V.

Kursk State Medical University

Panarina N.V.

Kursk State Medical University

Bushueva O.Yu.

Kursk State Medical University

Received:

03.12.2023

Accepted:

20.01.2024

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References:

  1. Samartsev VA, Parshakov AA, Gavrilov VA, Kuznetsova MV. Perioperative prevention of complications in surgery of ventral hernias. Khirurgiya. Zhurnal im. N.I. Pirogova. 2023;8:40-45. (In Russ.). https://doi.org/10.17116/hirurgia202308140
  2. Kazangapov RS, Kairkhanov EK, Imangazinov SB, Omarov NB. Prevention and treatment of wound complications with hernioplasty of postoperative ventral hernias. Medical Journal Astana. 2020;3(105):164-169. (In Russ.).
  3. Baranov VS. Genomics and predictive medicine. The Siberian Journal of Clinical and Experimental Medicine. 2021;36(4):14-28. (In Russ.). https://doi.org/10.29001/2073-8552-2021-36-4-14-28
  4. Demidova TYu, Zenina SG. Molecular genetic features of the diabetes mellitus development and the possibility of precision therapy. Diabetes Mellitus. 2020;23(5):467-474. (In Russ.). https://doi.org/10.14341/DM12486
  5. Kostiuk SA. Predictive medicine and methods of genetic testing. Meditsinskie Novosti. 2016;4:11-14. (In Russ.).
  6. Jorgenson E, Shen L, Avins A, Makki N, Eckalbar WL, Ahituv N, Chen DC, Tian C, Hinds D. A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia. Nature Communications. 2015;6:10130. https://doi.org/10.1038/ncomms10130
  7. Hikino K, Mushiroda T, Koido M, Tomizuka K, Liu X, Terao C, Morisaki T, Murakami Y, Momozawa Y. Susceptibility loci and polygenic architecture highlight population specific and common genetic features in inguinal hernias: genetics in inguinal hernias. EBioMedicine. 2021;70:103532. https://doi.org/10.1016/j.ebiom.2021.103532
  8. Choquet H, Li W, Bradley R, Hoffmann T J, Nandakumar Pr, Mostaedi R, Tian Ch, Ahituv N, Jorgenson E. Ancestry-and sex-specific effects underlying inguinal hernia susceptibility identified in a multiethnic genome-wide association study meta-analysis. Human Molecular Genetics. 2022;31(13):2279-2293. https://doi.org/10.1093/hmg/ddac003
  9. Patterson T, Currie P, Spence R, McNally S, Spence G. A systematic review of the association between a single strenuous event and the development of an inguinal hernia: a medicolegal grey area. Surgeon. 2018;16:309-314. 
  10. Vad MV, Frost P, Bay-Nielsen M, Svendsen SW. Impact of occupational mechanical exposures on risk of lateral and medial inguinal hernia requiring surgical repair. Occupational and Environmental Medicine. 2012;69(11):802-809.  https://doi.org/10.1136/oemed-2012-100787
  11. Svendsen SW, Frost P, Vad MV, Andersen JH. Risk and prognosis of inguinal hernia in relation to occupational mechanical exposures--a systematic review of the epidemiologic evidence. Scandinavian Journal of Work, Environment & Health. 2013;39(1):5-26.  https://doi.org/10.5271/sjweh.3305
  12. Mitura K, Śmietański M, Kozieł S, Garnysz K, Michałek I. Factors influencing inguinal hernia symptoms and preoperative evaluation of symptoms by patients: results of a prospective study including 1647 patients. Hernia. 2018;22(4):585-591.  https://doi.org/10.1007/s10029-018-1774-4
  13. Shakil A, Aparicio K, Barta E, Munez K. Inguinal Hernias: Diagnosis and Management. American Family Physician. 2020;102(8):487-492. 
  14. Somuncu S, Somuncu ÖS. A Comprehensive Review: Molecular and Genetic Background of Indirect Inguinal Hernias. Visceral Medicine. 2021;37(5):349-357.  https://doi.org/10.1159/000515275
  15. Fadista J, Skotte L, Karjalainen Ju, Abner E, Sørensen E, Ullum H, Werge T, Esko T, Milani L, Palotie A, Daly M, Melbye M, Feenstra B, Geller F. Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci. Nature Communications. 2022;13(1):1-11.  https://doi.org/10.1038/s41467-022-30921-4
  16. Ahmed WU-R, Patel MIA, Ng M, McVeigh J, Zondervan K, Wiberg A, Furniss D. Shared genetic architecture of hernias: A genome-wide association study with multivariable meta-analysis of multiple hernia phenotypes. PLoS ONE. 2022;17(12):e0272261. https://doi.org/10.1371/journal.pone.0272261
  17. Sander JD, Joung JK. Crispr-cas systems for editing, regulating and targeting genomes. Nature Biotechnology. 2014;32(4):347-350.  https://doi.org/10.1038/nbt.2842
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