Experimental studies of biodegradable ureteral stent prototype

Sedush N.G.; Anokhin E.A.; Chvalun S.N.; Semin A.V.; Korolev V.V.; Kotenko K.V.; Eremin I.I.; Korolev S.V.

doi:https://doi.org/10.17116/hirurgia2024122117

Sedush N.G.

Enikolopov Institute of Synthetic Polymeric Materials

ORCID: 0000-0002-6744-7662

Anokhin E.A.

Enikolopov Institute of Synthetic Polymeric Materials

Chvalun S.N.

Enikolopov Institute of Synthetic Polymeric Materials

ORCID: 0000-0001-9405-4509

Semin A.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-3787-146X

Korolev V.V.

Petrovsky National Research Center of Surgery

ORCID: 0009-0003-7203-9051

Kotenko K.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-6147-5574

Eremin I.I.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-4336-8986

Korolev S.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-2400-7971

Experimental studies of biodegradable ureteral stent prototype

Authors:

Sedush N.G., Anokhin E.A., Chvalun S.N., Semin A.V., Korolev V.V., Kotenko K.V., Eremin I.I., Korolev S.V.

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Journal: Pirogov Russian Journal of Surgery. 2024;(12‑2): 117‑121

DOI: 10.17116/hirurgia2024122117

Read: 755 times

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To cite this article:

Sedush NG, Anokhin EA, Chvalun SN, et al. . Experimental studies of biodegradable ureteral stent prototype. Pirogov Russian Journal of Surgery. 2024;(12‑2):117‑121. (In Russ.)
https://doi.org/10.17116/hirurgia2024122117

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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Abstract:

Degradable ureteral stent not requiring redo procedure for removal is an important issue in modern urology. This device could solve the problem of «forgotten stent» often leading to long-term complications. The authors describe the prototype of biodegradable ureteral stent based on poly(L-lactide-co-ε-caprolactone) and present the first results of its testing. Characteristics of synthesized polymer meet the requirements in medicine. Tests of rod-shaped stent prototypes showed that material has sufficient strength and elasticity. Analysis of stent degradation in artificial urine environment at 37 ºC showed that it retains strength for at least 2 weeks. No suppression of cell growth confirms no cellular toxicity. New material based on poly(L-lactide-co-ε-caprolactone) is promising for development of experimental samples of biodegradable ureteral stents and further in vivo testing.

Keywords:

ureteral stent

biodegradable polymers

hydrolytic degradation

mechanical testing

molecular weight

Authors:

Sedush N.G.

Enikolopov Institute of Synthetic Polymeric Materials

ORCID: 0000-0002-6744-7662

Anokhin E.A.

Enikolopov Institute of Synthetic Polymeric Materials

Chvalun S.N.

Enikolopov Institute of Synthetic Polymeric Materials

ORCID: 0000-0001-9405-4509

Semin A.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-3787-146X

Korolev V.V.

Petrovsky National Research Center of Surgery

ORCID: 0009-0003-7203-9051

Kotenko K.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-6147-5574

Eremin I.I.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-4336-8986

Korolev S.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0003-2400-7971

Received:

24.08.2024

Accepted:

13.09.2024

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References:

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