Serum creatine phosphokinase as a predictor of upper limb amputation in electrical trauma

Sachkov A.V.; Spiridonova T.G.; Zhirkova E.A.; Medvedev A.V.; Rogal M.L.

doi:https://doi.org/10.17116/hirurgia202305147

Sachkov A.V.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0003-3742-6374

Spiridonova T.G.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0001-7070-8512

Zhirkova E.A.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0002-9862-0229

Medvedev A.V.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0001-7159-7287

Rogal M.L.

Sklifosovsky Research Institute for Emergency Care

SPIN RSCI: 7175-1868
Scopus AuthorID: 6507792142
ResearcherID: B-9698-2019
ORCID: 0000-0003-1051-7663

Serum creatine phosphokinase as a predictor of upper limb amputation in electrical trauma

Authors:

Sachkov A.V., Spiridonova T.G., Zhirkova E.A., Medvedev A.V., Rogal M.L.

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Journal: Pirogov Russian Journal of Surgery. 2023;(5): 47‑52

DOI: 10.17116/hirurgia202305147

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To cite this article:

Sachkov AV, Spiridonova TG, Zhirkova EA, Medvedev AV, Rogal ML. Serum creatine phosphokinase as a predictor of upper limb amputation in electrical trauma. Pirogov Russian Journal of Surgery. 2023;(5):47‑52. (In Russ.)
https://doi.org/10.17116/hirurgia202305147

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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OBJECTIVE

To study the relationship between serum creatine phosphokinase and outcomes of injury in victims with electrical burns.

MATERIAL AND METHODS

Among 40 patients with electrical injury, 7 (18%) ones underwent upper limb amputation. There were 37 (92.5%) men and 3 (7.5%) women aged 37 (28; 47) years. We analyzed total serum creatine phosphokinase and MB fraction on the first day in patients with and without amputations.

RESULTS

Total serum creatine phosphokinase exceeded the upper reference value in 11 out of 33 patients without amputation and in all 7 patients with limb amputation (p=0.001). Patients with limb amputation had significantly higher total serum creatine phosphokinase and MB fraction (p<0.001 and p=0.030, respectively). Logistic regression equation showed that high total serum creatine phosphokinase significantly influenced amputation rate (p<0.001), as evidenced by odds ratio (42.7, 95% CI 3.5—514.8). ROC analysis revealed the cut-off value of total serum creatine phosphokinase (950 IU/L). Sensitivity was 100% (63; 100), specificity — 94% (86; 94), positive predictive value — 78% (49; 78), negative predictive value — 100% (92; 100).

CONCLUSION

Total serum creatine phosphokinase depends only on severity of electrical and flame burns. Serum creatine phosphokinase is a predictor of upper limb amputation in patients with electrical injury. Total serum creatine phosphokinase ≥ 950 IU/L is significant for upper limb amputation (in CK-MB fraction within the reference values).

Keywords:

electrical injury

electrical burn

upper limb amputation

creatine phosphokinase

MB fraction

Authors:

Sachkov A.V.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0003-3742-6374

Spiridonova T.G.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0001-7070-8512

Zhirkova E.A.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0002-9862-0229

Medvedev A.V.

Sklifosovsky Research Institute for Emergency Care

ORCID: 0000-0001-7159-7287

Rogal M.L.

Sklifosovsky Research Institute for Emergency Care

SPIN RSCI: 7175-1868
Scopus AuthorID: 6507792142
ResearcherID: B-9698-2019
ORCID: 0000-0003-1051-7663

Received:

21.09.2022

Accepted:

16.10.2022

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References:

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