Coronavirus infection and risk of postoperative venous thromboembolic events

Butyrsky A.G.; Mikhaylichenko V.Yu.; Golomidov A.N.; Khilko S.S.; Bobkov O.V.; Aliev A.S.; Rumyantseva M.I.; Butyrskaya I.B.

doi:https://doi.org/10.17116/hirurgia202206155

Butyrsky A.G.

Crimean Federal University

ORCID: 0000-0001-5415-3756

Mikhaylichenko V.Yu.

Georgievsky Medical Academy of the Vernadsky Crimean Federal University

ORCID: 0000-0003-0036-9329

Golomidov A.N.

Municipal Emergency Hospital no. 6

Khilko S.S.

Vernadsky Crimean Federal University

Bobkov O.V.

Vernadsky Crimean Federal University

Aliev A.S.

Crimean Federal University

ORCID: 0000-0002-0030-8940

Rumyantseva M.I.

Crimean Federal University

ORCID: 0000-0002-3591-4510

Butyrskaya I.B.

Vernadsky Crimean Federal University

ORCID: 0000-0002-4283-2572

Coronavirus infection and risk of postoperative venous thromboembolic events

Authors:

Butyrsky A.G., Mikhaylichenko V.Yu., Golomidov A.N., Khilko S.S., Bobkov O.V., Aliev A.S., Rumyantseva M.I., Butyrskaya I.B.

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Journal: Pirogov Russian Journal of Surgery. 2022;(6): 55‑61

DOI: 10.17116/hirurgia202206155

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To cite this article:

Butyrsky AG, Mikhaylichenko VYu, Golomidov AN, et al. Coronavirus infection and risk of postoperative venous thromboembolic events. Pirogov Russian Journal of Surgery. 2022;(6):55‑61. (In Russ.)
https://doi.org/10.17116/hirurgia202206155

Подписка 2026 Хирургия. Журнал им. Н.И. Пирогова (Pirogov Russian Journal of Surgery)

Использование инфографики авторами научных работ

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Abstract:

OBJECTIVE

To determine whether patients with perioperative or previous coronavirus infection (CVI) have a greater risk of venous thromboembolic events (VTE).

MATERIAL AND METHODS

A multiple-center regional prospective retrospective cohort study included elective and emergency patients who underwent surgery in November 2020. The primary endpoint was VTE (PE/DVT) within 30 days after surgery. CVI was stratified as perioperative (7 days before surgery — 30 days after surgery), recent (1—6 weeks before surgery) and remote (≥7 weeks before surgery) infection. There was no information about prevention or preoperative anticoagulation at baseline data collection.

RESULTS

Incidence of postoperative VTE was 1.5% (10/650) in patients without CVI, 33.3% (3/9) in patients with perioperative CVI, 18.1% (2/11) in patients with recent CVI and 8.3% (1/12) in patients with remote CVI. After adjusting the confounders, patients with perioperative and recent CVI remained at a higher risk of VTE. In general, VTEs were independently associated with 30-day mortality. In patients with CVI, mortality rate among ones without VTE was 21.7% (5/23), with VTE — 44.4% (4/9).

CONCLUSION

Patients with perioperative CVI have a higher risk of postoperative VTE compared to those without CVI and patients with previous CVI and no residual symptoms. Mortality in this group is also higher than in other cohorts.

Keywords:

surgical pathology

new coronavirus infection

thromboembolic events

Authors:

Butyrsky A.G.

Crimean Federal University

ORCID: 0000-0001-5415-3756

Mikhaylichenko V.Yu.

Georgievsky Medical Academy of the Vernadsky Crimean Federal University

ORCID: 0000-0003-0036-9329

Golomidov A.N.

Municipal Emergency Hospital no. 6

Khilko S.S.

Vernadsky Crimean Federal University

Bobkov O.V.

Vernadsky Crimean Federal University

Aliev A.S.

Crimean Federal University

ORCID: 0000-0002-0030-8940

Rumyantseva M.I.

Crimean Federal University

ORCID: 0000-0002-3591-4510

Butyrskaya I.B.

Vernadsky Crimean Federal University

ORCID: 0000-0002-4283-2572

Received:

23.09.2021

Accepted:

02.10.2021

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References:

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