Down’s syndrome with congenital acute leukemia and congenital heart disease

Petrova O.V.

Federal Center for Cardiovascular Surgery;
Astrakhan State Medical University

Murygina O.I.

Federal Center for Cardiovascular Surgery

Shashin S.A.

Astrakhan State Medical University

Nikulina D.M.

Astrakhan State Medical University

Tarasov D.G.

Federal Center for Cardiovascular Surgery;
Astrakhan State Medical University

Down’s syndrome with congenital acute leukemia and congenital heart disease

Authors:

Petrova O.V., Murygina O.I., Shashin S.A., Nikulina D.M., Tarasov D.G.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2020;(12): 111‑114

DOI: 10.17116/hirurgia2020121111

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To cite this article:

Petrova OV, Murygina OI, Shashin SA, Nikulina DM, Tarasov DG. Down’s syndrome with congenital acute leukemia and congenital heart disease. Pirogov Russian Journal of Surgery. 2020;(12):111‑114. (In Russ.)
https://doi.org/10.17116/hirurgia2020121111

Подписка 2025 (Pirogov Russian Journal of Surgery)

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OBJECTIVE

To report a rare case of Down’s syndrome with congenital acute leukemia and congenital heart disease.

MATERIAL AND METHODS

We have retrospectively analyzed an electronic database of patients aged 0-17 years who underwent inpatient treatment of congenital heart disease at the Federal Center for Cardiovascular Surgery for the period from January 1, 2010 to December 31, 2018. Incidence of Down’s syndrome in children with congenital heart defects was 5.36% of the total number of children with congenital heart defects. No gender differences were identified. The most common congenital heart defects were ventricular septal defect, atrioventricular septal defect, atrial septal defect, patent ductus arteriosus, tetralogy of Fallot. Down’s syndrome and congenital heart disease were diagnosed prenatally in 33 out of 319 patients. A rare case of Down’s syndrome combined with congenital heart disease and acute leukemia is described. Treatment outcome was unfavorable.

CONCLUSION. S

Evere concomitant diseases in a child with Down’s syndrome determine high postoperative morbidity and mortality. Prenatal diagnosis of Down’s syndrome via screening of pregnant women for ultrasound and biochemical markers of this pathology is required.

Keywords:

acute leukemia

congenital heart disease

Down’s syndrome

children of the first year of life

Authors:

Petrova O.V.

Federal Center for Cardiovascular Surgery;
Astrakhan State Medical University

Murygina O.I.

Federal Center for Cardiovascular Surgery

Shashin S.A.

Astrakhan State Medical University

Nikulina D.M.

Astrakhan State Medical University

Tarasov D.G.

Federal Center for Cardiovascular Surgery;
Astrakhan State Medical University

Received:

16.12.2019

Accepted:

13.02.2020

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