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Lutsevich O.

GBOU VPO "Moskovskiĭ gosudarstvennyĭ mediko-stomatologicheskiĭ universitet im. A.I. Evdokimova" Minzdrava Rossii

Akimov V.P.

N.D. Monastyrsky Department of Surgery, Mechnikov Northwestern State Medical University, St. Petersburg, Russia

Shirinsky V.G.

Department of faculty surgery №1, Yevdokimov Moscow State Medical Dental University

Bichev A.A.

Eudokimov’s Moscow Medical-Stomatological University, Moscow, Russia

Adhesive disease of the peritoneum: modern view at pathogenesis and treatment

Authors:

Lutsevich O., Akimov V.P., Shirinsky V.G., Bichev A.A.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2017;(10): 100‑108

Read: 16235 times


To cite this article:

Lutsevich O, Akimov VP, Shirinsky VG, Bichev AA. Adhesive disease of the peritoneum: modern view at pathogenesis and treatment. Pirogov Russian Journal of Surgery. 2017;(10):100‑108. (In Russ.)
https://doi.org/10.17116/hirurgia201710100-108

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References:

  1. Aluev ShA, Sirmatova LI, Kislitzyna EM, Shestakova IM. [Novy podkhod k profilaktike spaechnogo processa v operativnoi ginekologii. Materialy X yubileinogo vserossiyskogo foruma «Mat’ i Ditia». September 29 — October 2, 2009. M. Accessed October 27, 2016. Available at: http://www.mesogel.ru/surgeon/aluev2009.pdf (In Russ.)
  2. Krutova VA, Makarenko LV, Avagimova OV, Kravtzov II, Kravtzova NA, Melkoniants TG, Titova AN, Tyutyunnikova NS, Storozhuk AP. The rehabilitation of infertile women with external genital endometriosis after surgical treatment. Kubanskiy nauchniy meditsinskiy vestnik. 2012;4:60-64. (In Russ.)
  3. Mailova KS, Osipova AA, Korona R, Binda M, Koninckx F, Adamian LV. Faktory, vliyayushie na obrazovanie spaiek pri laparoskopicheskikh operatsiah. Nauchnye vedomosti. Seria Meditsina. Farmacia. 2012;17(4):201-206. (In Russ.)
  4. Vorobiev AA, Barinova EA, Barinov AS, Pisarev VB, Moskvichev SM, Zheltobriukhov VF. Russianpatent №2202279/23.05.2001. Bull. №11. Sposob otzenki spaechnogo processa. Accessed October 27, 2016. Ref: http:bd.patent.su/2202000-2202999/pat/servl/servleta895.html (In Russ.)
  5. Sukovatykh BS, Myasnikov AD, Bezhin AI, Lazarenko VA, Lipatov VA, Dubonos AA, Zhukovsky VA, Verbitsky DA. The efficiency of antiadhesive means with «mezogel» having a barrier effect after dissection of the adhesions in patients with acute ad- hesive intestinal obstruction. Vestnik khirurgii, 2008;167(5):29-32. (In Russ.)
  6. Adhesion Barrier Study Group. Prevention of postsurgical adhesions by INTERCEED (TC7), an absorbable adhesion barrier: a prospective randomized multicenter clinical study. Fertil Steril. 1989;51(6):933-938. https://doi.org/10.1016/s0015-0282(16)60721-5
  7. Ahmad G, O’Flynn H, Hindocha A, Watson A. Barrier agents for adhesion prevention after gynaecological surgery. Cochrane Database Syst Rev. CD000475. 2015. https://doi.org/10.1002/14651858.cd000475.pub3
  8. American Fertility Society. The AFS classification of adnexal adhesions, distal tubal occlusion, tubal occlusion secondary to tubal ligation, tubal pregnancies, Müllerian anomalies and intrauterine adhesions. Fertil Steril. 1988;49(6):944-955. https://doi.org/10.1016/s0015-0282(16)59942-7
  9. Avsar F, Sahin M, Aksoy F, Avsar AF, Aköz M, Hengirmen S, Bilici S. Effects of diphenhydramine HCl and methylprednisolone in the prevention of abdominal adhesions. Am J Surg. 2001;181(6):512-515. https://doi.org/10.1016/s0002-9610(01)00617-1
  10. Beck DE, Cohen Z, Fleshman JW, Kaufman HS, van Goor H, Wolff BG. Adhesion Study Group Steering Committee. A prospective, randomised, multicenter, controlled study of the safety of seprafilm adhesion barrier in abdominopelvic surgery of the intestine. Dis Colon Rectum. 2003;46(10):1310-1319. https://doi.org/10.1007/s10350-004-6739-2
  11. Berkkanoglu M, Zhang L, Ulukus M, Cakmak H, Kayisli UA, Kursun S, Arici A. Inhibition of chemokines prevents intraperitoneal adhesions in mice. Hum Reprod. 2005;20(11):3047-3052. https://doi.org/10.1093/humrep/dei182
  12. Binda M.M. Humidification during laparoscopic surgery: overview of the clinical benefits of using humidified gas during laparoscopic surgery. Arch Gynecol Obstet. 2015;292(5):955-971. https://doi.org/10.1007/s00404-015-3717-y
  13. Binda MM, Molinas CR, Koninckx PR. Reactive oxygen species and adhesion formation: clinical implications in adhesion prevention. Hum Reprod. 2003;18(12):2503-2507. https://doi.org/10.1093/humrep/deg481
  14. Bronson RA, Wallach EE. Lysis of periadnexal adhesions for correction of infertility. Fertil Steril. 1977;28(6):613-619.
  15. Buckenmaier CC 3rd, Pusateri AE, Harris RA, Hetz SP. Comparison of antiadhesive treatments using an objective rat model. Am Surg. 1999;65(3):274-282.
  16. Cahill RA, Wang JH, Soohkai S, Redmond HP. Mast cells facilitate local VEGF release as an early event in the pathogenesis of postoperative peritoneal adhesions. Surgery 2006;140(1):108-112. https://doi.org/10.1016/j.surg.2006.01.020
  17. Chapman WC, Lockstadt H, Singla N, Kafie FE, Lawson JH. Phase 2, randomized, double-blind, placebo-controlled, multicenter clinical evaluation of recombinant human thrombin in multiple surgical indications. J Thromb Haemost. 2006;4(9):2083-2085. https://doi.org/10.1111/j.1538-7836.2006.02067.x
  18. Chegini N, Kotseos K, Zhao Y, Ma C, McLean F, Diamond MP, Holmdahl L, Burns J. Peritoneal Healing and Adhesion Multiuniversity Study Group. Expression of matrix metalloproteinase (MMP-1) and tissue inhibitor of MMP in serosal tissue of intraperitoneal organs and adhesions. Fertil Steril. 2001;76(6):1212-1219. https://doi.org/10.1016/s0015-0282(01)02875-8
  19. Chen MD, Teigen GA, Reynolds HT, Johnson PR, Fowler JM. Laparoscopy versus laparotomy: an evaluation of adhesion formation after pelvic and paraaortic lymphadenectomy in a porcine model. Am J Obstet Gynecol. 1998;178(3):499-503. https://doi.org/10.1016/s0002-9378(98)70428-4
  20. Chowdhury SM, Hubbell JA. Adhesion prevention with ancrod released via a tissue-adherent hydrogel. J Surg Res. 1996;61(1):58-64. https://doi.org/10.1006/jsre.1996.0081
  21. Coccolini F, Ansaloni L, Manfredi R, Campanati L, Poiasina E, Bertoli P, Capponi MG, Sartelli M, Di Saverio S, Cucchi M, Lazzareschi D, Pisano M, Catena F. Peritoneal adhesion index (PAI): proposal of a score for the «ignored iceberg» of medicine and surgery. World J Emerg Surg. 2013;8(1):6:1-5. https://doi.org/10.1186/1749-7922-8-6
  22. Cohen Z, Senagore A, Dayton M, Koruda MJ, Beck DE, Wolff BG, Fleshner PR, Thirlby RC, Ludwig KA, Larach SW, Weiss EG, Bauer JJ, Holmdahl L. Prevention of postoperative abdominal adhesions by a novel, glycerol/sodium hyaluronate/carboxymethylcellulose-based bioresorbable membrane: a prospective, randomised, evaluator-blinded multicenter study. Dis Colon Rectum. 2005;48(6):1130-1139. https://doi.org/10.1016/s0090-3671(08)70461-0
  23. de la Portilla F, Ynfante I, Bejarano D, Conde J, Fernández A, Ortega JM, Carranza G. Prevention of peritoneal adhesions by intraperitoneal administration of vitamin E: an experimental study in rats. Dis Colon Rectum. 2005;47(12):2157-2161. https://doi.org/10.1007/s10350-004-0741-6
  24. De Wilde RL, Brölmann H, Koninckx PR, Lundorff P, Lower AM, Wattiez A, Mara M, Wallwiener M. The Anti-Adhesions in Gynecology Expert Panel (ANGEL). Prevention of adhesions in gynaecological surgery: the 2012 European field guideline. Gynecol Surg. 2012;9(4):365-368. https://doi.org/10.1007/s10397-012-0764-2
  25. DeCherney AH, diZerega GS. Clinical problem of intraperitoneal postsurgical adhesion formation following general surgery and the use of adhesion prevention barriers. Surg Clin North Am. 1997;77(3):671-688. https://doi.org/10.1016/s0039-6109(05)70574-0
  26. Di Saverio S, Coccolini F, Galati M. Group of authors. Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2013 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group. World Journal of Emergency Surgery. 2013;8(1):42. https://doi.org/10.1186/1749-7922-8-42
  27. Diamond MP, DeCherney AH, Linsky CB, Cunningham T, Constantine B. Adhesion reformation in the rabbit uterine horn model. I. Reduction with carboxymethylcellulose. Int J Fertil. 1988;33(5):372-375.
  28. Diamond MP, DeCherney AH, Linsky CB, Cunningham T, Constantine B. Assessment of carboxymethylcellulose and 32% dextran 70 for prevention of adhesions in a rabbit uterine horn model. Int J Fertil. 1988;33(4):278-282.
  29. di Zerega GS. Peritoneum, peritoneal healing and adhesion formation. In: Peritoneal Surgery. Springer Verlag, NY. 2000;3-37. https://doi.org/10.1007/978-1-4612-1194-5_1
  30. diZerega GS, Coad J, Donnez J. Clinical evaluation of endometriosis and differential response to surgical therapy with and without application of Oxiplex/AP* adhesion barrier gel. Fertil Steril. 2007;87(3):485-489. https://doi.org/10.1016/j.fertnstert.2006.07.1505
  31. di Zerega GS, Cortese S, Rodgers KE, Block KM, Falcone SJ, Juarez TG, Berg R. A Modern Biomaterial for Adhesion Prevention. J Biomed Mater Res B Appl Biomater. 2007;81(1):239-250. https://doi.org/10.1002/jbm.b.30659
  32. Elkins TE, Bury RJ, Ritter JL, Ling FW, Ahokas RA, Homsey CA, Malinak LR. Adhesion prevention by solutions of sodium carboxymethylcellulose in the rat. I Fertil Steril. 1984;41(6):926-928. https://doi.org/10.1016/s0015-0282(16)47909-4
  33. Ellis H. The clinical significance of adhesions: focus on intestinal obstruction. Eur J Surg Suppl. 1997;(577):5-9.
  34. Farley DR, Greenlee SM, Larson DR, Harrington JR. Double-blind, prospective, randomized study of warmed, humidified carbon dioxide insufflation vs standard carbon dioxide for patients undergoing laparoscopic cholecystectomy. Arch. Surg. 2004;139(7):739-743; discussion 743-744. https://doi.org/10.1001/archsurg.139.7.739
  35. Farquhar C, van de Kerckhove P, Watson A, Vail A, Wiseman D. Barrier agents for preventing adhesions after surgery for subfertility. Cochrane Database Systematic Rev. 2002;4:1-34:CD000475. https://doi.org/10.1002/14651858.cd000475
  36. Fevang BTS, Fevang J, Lie SA, Søreide O, Svanes K, Viste A. Long-term prognosis after operation for adhesive small bowel obstruction. Ann Surg. 2004;240(2):193-201. https://doi.org/10.1097/01.sla.0000132988.50122.de
  37. Flessner MF. The transport barrier in intraperitoneal therapy. Am J Physiol Renal Physiol. 2005;288(3):433-442. https://doi.org/10.1152/ajprenal.00313.2004
  38. Fredericks CM, Kotry I, Holtz G, Askalani AH, Serour GI. Adhesion prevention in the rabbit with sodium carboxymethylcellulose solutions. Am J Obstet Gynecol. 1986;155(3):667-670. https://doi.org/10.1016/0002-9378(86)90304-2
  39. Gago LA, Saed GM, Wang RX, Kruger M, Diamond MP. Effects of oxidized regenerated cellulose on the expression of extracellular matrix and transforming growth factor-beta1 in human peritoneal fibroblasts and mesothelial cells. Am J Obstet Gynecol. 2003;189(6):1620-1625; discussion 1625-1626. https://doi.org/10.1016/j.ajog.2003.08.018
  40. Garrard CL, Clements RH, Nanney L, Davidson JM, Richards WO. Adhesion formation is reduced after laparoscopic surgery. Surg Endosc. 1999;13(1):10-13. https://doi.org/10.1007/s004649900887
  41. Garrett Q, Simmons PA, Xu S, Vehige J, Zhao Z, Ehrmann K, Willcox M. Carboxymethylcellulose binds to human corneal epithelial cells and is a modulator of corneal epithelial wound healing. Invest Ophthalmol Vis Sci. 2007;48(4):1559-1567. https://doi.org/10.1167/iovs.06-0848
  42. Golan A, Winston RML. Blood and intraperitoneal adhesion formation in the rat. J Obstet Gynaec. 1989;9(3):248-252. https://doi.org/10.3109/01443618909151053
  43. Golander CG, Herron JN, Claesson KL, Stenius P, Andrade JD. Properties of immobilized PEG films and the interaction with proteins: experiments and modeling. In: Harris JM (ed). Poly (ethylene glycol) Chemistry: Biotechnical and Biomedical Applications. New York, NY: Plenum; 1992.
  44. Gómez-Gil V, García-Honduvilla N, Pascual G, Rodríguez M, Buján J, Bellón JM. Peritoneal adhesion formation and reformation tracked by sequential laparoscopy: optimizing the time point for adhesiolysis. Surgery. 2010;147(3):378-391. https://doi.org/10.1016/j.surg.2009.10.011
  45. Gutt CN, Oniu T, Schemmer P, Mehrabi A, Büchler MW. Fewer adhesions induced by laparoscopic surgery? Surg Endosc. 2004;18(6):898-906. https://doi.org/10.1007/s00464-005-0718-0
  46. Gynecare Interceed absorbable adhesion barrier. Essential Product Information EPI CR Approved 2-25-09. Accessed October 27, 2016. Available at: https://www.ethicon.com/sites/default/files/managed-documents/044412-151208_franklin_gynecare_interceed_clinical_summary_ca.pdf
  47. Haney A, Hesla J, Hurst B, Kettel LM, Murphy AA, Rock JA, Rowe G, Schlaff WD. Expanded polytetrafluororethylene (Gore-Tex Surgical Membrane) is superior to oxidized regenerated cellulose (Interceed TC7+) in preventing adhesions. Fertil Steril. 1995;63(5):1021-1026. https://doi.org/10.1016/s0015-0282(16)57541-4
  48. Haney AF, Doty E. A barrier composed of chemically cross-linked hyaluronic acid (Incert) reduces postoperative adhesion formation. Fertil Steril. 1998;70(1):145-151. https://doi.org/10.1016/s0015-0282(98)00116-2
  49. Hermans MH, Brown L, Darmoc M. Adhesion prevention in an intraperitoneal wound model: performance of two resorbable hemostats in a controlled study in rabbits. J Biomed Mater Res B Appl Biomater. 2012;100(6):1621-1626. https://doi.org/10.1002/jbm.b.32730
  50. Hindocha A, Beere L, Dias S, Watson A, Ahmad G. Adhesion prevention agents for gynaecological surgery: an overview of Cochrane reviews. Cochrane Database Syst Rev. 2015;1:CD011254. https://doi.org/10.1002/14651858.cd011254
  51. Höckel M, Ott S, Siemann U, Kissel T. Prevention of peritoneal adhesions in the rat with sustained intraperitoneal dexamethasone delivered by a novel therapeutic system. Ann Chir Gynaecol. 1987;76(6):306-313.
  52. Holmdahl L, Kotseos K, Bergström M, Falk P, Ivarsson ML, Chegini N. Overproduction of transforming growth factor-beta1 (TGF-beta1) is associated with adhesion formation and peritoneal fibrinolytic impairment. Surgery. 2001;129(5):626-632. https://doi.org/10.1067/msy.2001.113039
  53. Holmdahl LE, Al-Jabreen M, Risberg B. Role of fibrinolysis in the formation of postoperative adhesions. Wound Repair Regen. 1994;2(3):171-176. https://doi.org/10.1046/j.1524-475x.1994.20306.x
  54. Holtz G. Failure of a nonsteroidal anti-inflammatory agent (ibuprofen) to inhibit peritoneal adhesion reformation after lysis. Fertil Steril. 1982;37(4):582-583. https://doi.org/10.1016/s0015-0282(16)46171-6
  55. Hoshino A, Kawamura YI, Yasuhara M, Toyama-Sorimachi N, Yamamoto K, Matsukawa A, Lira SA, Dohi T. Inhibition of CCL1-CCR8 interaction prevents aggregation of macrophages and development of peritoneal adhesions. J Immunol. 2007;178(8):5296-5304. https://doi.org/10.1016/s0090-3671(08)79025-6
  56. Hulka JF. Adnexal adhesions, a prognostic staging and classification system based on a 5-year survey of fertility surgery results at Chapel Hill, North Carolina. Am J Obstet and Gynecol. 1982;144(2):141-148. https://doi.org/10.1016/0002-9378(82)90615-9
  57. Hulka JF, Reich H. Text book of laparoscopy. Philadelphia: W.B. Sounders; 1998.
  58. Johns DA, Ferland R, Dunn R. Initial feasibility study of a sprayable hydrogel adhesion barrier system in patients undergoing laparoscopic ovarian surgery. J Am Assoc Gynecol Laparosc. 2003;10(3):334-338. https://doi.org/10.1016/s1074-3804(05)60257-5
  59. Kang BW, Lee HS, Oh HJ, Yoon KC. Clinical effect of a mixed solution of sodium hyaluronate and sodium carboxymethylcellulose during the transconjunctival approach for orbital wall reconstruction. Chonnam Med J. 2012;48(2):123-127. https://doi.org/10.4068/cmj.2012.48.2.123
  60. Kitano T, Zerwekh JE, Edwards ML, Usui Y, Allen MD. Viscous carboxymethylcellulose in the prevention of epidural scar formation. Spine (Phila Pa 1976). 1991;16(7):820-823. https://doi.org/10.1097/00007632-199107000-00023
  61. Koninckx PR, Binda MM, Corona R, Molinas CR. Postoperative adhesions and their prevention. In: Reconstructive and Reproductive Surgery in Gynecology (ed. by). Gomel V., Brill A. (eds). CRC Press. Informa Healthcare. 2010;8-17. https://doi.org/10.3109/9781841847573-3
  62. Koninckx PR, Corona R, Timmerman D, Verguts J, Adamyan L. Peritoneal full-conditioning reduces postoperative adhesions and pain: a randomised controlled trial in deep endometriosis surgery. J Ovarian Res. 2013;6(1):90. https://doi.org/10.1186/1757-2215-6-90
  63. Koninckx PR, Gomel V, Ussia A, Adamyan L. Role of the peritoneal cavity in the prevention of postoperative adhesions, pain, and fatigue. Fertil Steril. 2016;106(5):998-1010. https://doi.org/10.1016/j.fertnstert.2016.08.012
  64. Korell M. Adhesion prophylaxis in Gynecology. In: Peritoneal Adhesions. Treutner K.-H., Schumpelick V. (eds) Berlin-Heidelberg, Springer-Verlag; 1997.
  65. Kovacs EJ. Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today. 1991;12(1):17-23. https://doi.org/10.1016/0167-5699(91)90107-5
  66. Kovacs EJ, DiPietro LA. Fibrogenic cytokines and connective tissue production. FASEB J. 1994;8(11):854-861.
  67. Kusunoki M, Ikeuchi H, Yanagi H, Noda M, Tonouchi H, Mohri Y, Uchida K, Inoue Y, Kobayashi M, Miki C, Yamamura T. Bioresorbable hyaluronate-carboxymethylcellulose membrane (Seprafilm) in surgery for rectal carcinoma: a prospective randomised clinical trial. Surg Today. 2005;35(11):940-945. https://doi.org/10.1007/s00595-005-3061-0
  68. Leach RE, Burns JW, Dawe EJ, Smith Barbour MD, Diamond MP. Reduction of postsurgical adhesion formation in the rabbit uterine horn model with use of hyaluronate/carboxymethylcellulose gel. Fertil Steril. 1998;69(3):415-418. https://doi.org/10.1016/s0015-0282(97)00573-6
  69. Lee JH, Ju YM, Lee WK, Park KD, Kim YH. Platelet adhesion onto segmented polyurethane surfaces modified by PEO- and sulfonated PEO-containing block copolymer additives. J Biomed Mater Res. 1998;40(2):314-323. https://doi.org/10.1002/(sici)1097-4636(199805)40:2<314::aid-jbm17>3.0.co;2-l
  70. LeGrand EK, Rodgers KE, Girgis W, Struck K, Campeau JD, di Zerega GS, Kiorpes TC. Efficacy of tolmetin sodium for adhesion prevention in rabbit and rat models. J Surg Res. 1994;56(1):67-71. https://doi.org/10.1006/jsre.1994.1011
  71. Leibler L. Theory of Microphase Separation in Block Copolymers. Macromolecules. 1980;13(6):1602-1617. https://doi.org/10.1021/ma60078a047
  72. Levy O, Martinowitz U, Oran A, Tauber C, Horoszowski H. The use of fibrin tissue adhesive to reduce blood loss and the need for blood transfusion after total knee arthroplasty. A prospective, randomized, multicenter study. J Bone Joint Surg Am. 1999;81(11):1580-1588.
  73. Liu LS, Berg R. Chemically activated carboxypolysaccharides and methods for use to inhibit adhesion formation and promote hemostasis. US patent 6,923,961 B2, Aug. 2, 2005.
  74. Liu LS, Berg RA. Adhesion barriers of carboxymethylcellulose and polyethylene oxide composite gels. J Biomed Mater Res. 2002;63(3):326-332. https://doi.org/10.1002/jbm.10211
  75. Liu Y, Li H, Shu XZ, Gray SD, Prestwich GD. Crosslinked hyaluronan hydrogels containing mitomycin C reduce postoperative abdominal adhesions. Fertil Steril. 2005;83(suppl 1):1275-1283. https://doi.org/10.1016/j.fertnstert.2004.09.038
  76. Lucas P, Warejcka D, Young H, Lee BY. Formation of abdominal adhesions is inhibited by antibodies to transforming growth factorbeta1. J Surg Res. 1996;65(2):135-138. https://doi.org/10.1006/jsre.1996.0355
  77. Lundorff P, Donnez J, Korell M, Audebert AJ, Block K, di Zerega GS. Clinical evaluation of a viscoelastic gel for reduction of adhesions following gynaecological surgery by laparoscopy in Europe. Hum Reprod. 2005;20(2):514-520. https://doi.org/10.1093/humrep/deh651
  78. Mahdy T, Mohamed G, Elhawary A. Effect of methylene blue on intra-abdominal adhesion formation in rats. Int J Surg. 2008;6(6):452-455. https://doi.org/10.1016/j.ijsu.2008.08.004
  79. Menzies D, Ellis H. Intestinal obstruction from adhesions — how big is the problem? Ann R Coll Surg Engl. 1990;72(1):60-63.
  80. Menzies D, Pascual MH, Walz MK, Duron JJ, Tonelli F, Crowe A, Knight A. ARIEL Registry. Use of icodextrin 4% solution in the prevention of adhesion formation following general surgery: from the multicentre ARIEL Registry. Ann R Coll Surg Engl. 2006;88(4):375-382. https://doi.org/10.1308/003588406x114730
  81. Miller G, Boman J, Shrier I, Gordon PH. Natural history of patients with adhesive small bowel obstruction. Br J Surg. 2000;87(9):1240-1247. https://doi.org/10.1046/j.1365-2168.2000.01530.x
  82. Molinas CR, Koninckx PR. Hypoxaemia induced by CO 2 or helium pneumoperitoneum is a co-factor in adhesion formation in rabbits. Hum Reprod. 2000;15(8):1758-1763. https://doi.org/10.1093/humrep/15.8.1758
  83. Molinas CR, Mynbaev O, Pauwels A, Novak P, Koninckx PR. Peritoneal mesothelial hypoxia during pneumoperitoneum is a cofactor in adhesion formation in a laparoscopic mouse model. Fertil Steril. 2001;76(3):560-567. https://doi.org/10.1016/s0015-0282(01)01964-1
  84. Nordic Adhesion Prevention Study Group. The efficacy of Interceed (TC7)* for prevention of reformation of postoperative adhesions on ovaries, fallopian tubes, and fimbriae in microsurgical operations for fertility: a multicenter study. Fertil Steril. 1995;63(4):709-714. https://doi.org/10.1016/s0015-0282(16)57470-6
  85. Okuyama N, Rodgers KE, Wang CY, Girgis W, Oz M, St Amand K, Pines E, De Cherney AH, Rose EA, Cohn D, di Zerega GS. Prevention of retrosternal adhesion formation in a rabbit model using bioresorbable films of polyethylene glycol and polylactic acid. J Surg Res. 1998;78(2):118-122. https://doi.org/10.1006/jsre.1998.5317
  86. O’Sullivan D, O’Riordain M, O’Connell RP, Dineen M, Brady MP. Peritoneal adhesion formation after lysis: Inhibition by polyethylene glycol 4000. Br J Surg. 1991;78(4):427-429. https://doi.org/10.1002/bjs.1800780414
  87. Perlitz Y, Oettinger M, Karam K, Lipshitz B, Simon K. Anaphylactic shock during hysteroscopy using Hyskon solution: case report and review of adverse reactions and their treatment. Gynecol Obstet Invest. 1996;41(1):67-69. https://doi.org/10.1159/000292042
  88. Portz D, Elkins T, White R, Warren J, Adadevoh S, Randolph J. Oxygen free radicals and pelvic adhesions formation: I. Blocking oxygen free radical toxicity to prevent adhesion formation in an endometriosis model. Int J Fertil. 1991;36(1):39-42.
  89. Raftery AT. Regeneration of parietal and visceral peritoneum: an electron microscopical study. J Anat. 1973;115(Pt 3):375-392. https://doi.org/10.1002/bjs.1800601214
  90. Ray NF, Denton WG, Thamer M, Henderson SC, Perry S. Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994. J Am Coll Surg. 1998;186(1):1-9. https://doi.org/10.1016/s1072-7515(97)00127-0
  91. Replogle RL, Johnson R, Gross RE. Prevention of postoperative intestinal adhesions with combined promethazine and dexamethasone therapy: experimental and clinical studies. Ann Surg. 1966;163(4):580-588. https://doi.org/10.1016/0022-3468(66)90155-2
  92. Ryan GB, Grobéty J, Majno G. Postoperative peritoneal adhesions. A study of the mechanisms. Am J Pathol. 1971;65(1):117-148.
  93. ten Broek RP, Stommel MW, Strik C, van Laarhoven CJ, Keus F, van Goor H. Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis. Lancet. 2014;383(9911):48-59. https://doi.org/10.1016/s0140-6736(13)61687-6
  94. Tingstedt B, Isaksson K, Andersson E, Andersson R. Prevention of abdominal adhesions-present state and what’s beyond the horizon? Eur Surg Res. 2007;39(5):259-268. https://doi.org/10.1159/000102591
  95. Trew GS. Postoperative adhesions and their prevention. Reviews in Gynaecological and Perinatal Practice 2006;6(1):47-56. https://doi.org/10.1016/j.rigapp.2006.02.001
  96. Wiseman DM. Possible intergel reaction syndrome (pIRS). Ann Surg. 2006;244(4):630-632. https://doi.org/10.1097/01.sla.0000239619.93579.ca
  97. Wiseman DM, Trout JR, Franklin RR, Diamond MP. Metaanalysis of the safety and efficacy of an adhesion barrier (Interceed TC7) in laparotomy. J Reprod Med. 1999;44(4):325-331.
  98. Wurster SH, Bonet V, Mayberry A, Hoddinott M, Williams T, Chaudry IH. Intraperitoneal sodium carboxymethylcellulose administration prevents reformation of peritoneal adhesions following surgical lysis. J Surg Res. 1995;59(1):97-102. https://doi.org/10.1006/jsre.1995.1138
  99. Yeo Y, Ito T, Bellas E, Highley CB, Marini R, Kohane DS. In situ cross-linkable hyaluronan hydrogels containing polymeric nanoparticles for preventing postsurgical adhesions. Ann Surg. 2007;245(5):819-824. https://doi.org/10.1097/01.sla.0000251519.49405.55
  100. Young P, Johns A, Templeman C, Witz C, Webster B, Ferland R, Diamond MP, Block K, diZerega G. Reduction of postoperative adhesions after laparoscopic gynecological surgery with Oxiplex/AP Gel: a pilot study. Fertil Steril. 2005;84(5):1450-1456. https://doi.org/10.1016/j.fertnstert.2005.04.055
  101. Yu SL, Singh S, Chen HW, Chen HY, Chen JJ, Chen WJ, Chen HS, Chen SC. Intra-abdominal adhesion formation induces antioxidative injury, enhances cell proliferation, and prevents complement-mediated lysis. Wound Repair Regen. 2008;16(3):388-398. https://doi.org/10.1111/j.1524-475x.2008.00378.x
  102. Zadow JG, Hill RD. The precipitation of proteins by carboxymethyl cellulose. J Dairy Res. 1975;42(2):267-275. https://doi.org/10.1017/s0022029900015302
  103. Zeyneloglu HB, Senturk LM, Seli E, Oral E, Olive DL, Arici A. The role of monocyte chemotactic protein-1 in intraperitoneal adhesion formation. Hum Reprod. 1998;13(5):1194-1199. https://doi.org/10.1093/humrep/13.5.1194
  104. Zhou J, Elson C, Lee TD. Reduction in postoperative adhesion formation and re-formation after an abdominal operation with the use of N,O-carboxymethyl chitosan. Surgery. 2004;135(3):307-312. https://doi.org/10.1016/j.surg.2003.07.005

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