26 animals (13 pigs and 13 rabbits) were involved in the study. Liquid nitrogen cryodestruction experimental  machine was used. The following measurements and investigation were performed: invasive temperature measurement, intraoperative ultrasound, magnetic resonance imaging and pathomorphologic assessment. An ice sphere was hypoechogenic with hyperechogenic  contour by ultrasound.  Postoperative MRI showed signs of local ischemic oedema in cryodestruction zone, no signs of bleeding were detected. Morphologically zones of total necrosis, oedema and minor dystrophic changes were recognized. Cryodestruction proved to be a reliable technique of cold brain necrosis.