Mitral homograft for atrioventricular valve replacement — a problem at the interface of tissue engineering and surgery

Komarov R.N.; Tsaregorodtsev A.V.; Nuzhdin M.D.

doi:https://doi.org/10.17116/kardio20251801134

Komarov R.N.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-3904-6415

Tsaregorodtsev A.V.

Pirogov Russian National Research Medical University

ORCID: 0000-0001-7181-3779

Nuzhdin M.D.

Chelyabinsk Regional Clinical Hospital

ORCID: 0000-0002-7269-6727

Mitral homograft for atrioventricular valve replacement — a problem at the interface of tissue engineering and surgery

Authors:

Komarov R.N., Tsaregorodtsev A.V., Nuzhdin M.D.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(1): 34‑40

DOI: 10.17116/kardio20251801134

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To cite this article:

Komarov RN, Tsaregorodtsev AV, Nuzhdin MD. Mitral homograft for atrioventricular valve replacement — a problem at the interface of tissue engineering and surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;18(1):34‑40. (In Russ.)
https://doi.org/10.17116/kardio20251801134

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)

Использование инфографики авторами научных работ

Abstract:

The authors analyzed evolution of surgical and bioengineering approach to implantation and preparation of frameless human mitral valve for atrioventricular heart valve replacement. World and domestic experience in solving these problems is reflected. The authors analyze advanced methods in preparation of homografts that have the potential for the highest biocompatibility and rapid repopulation by own tissues.

Keywords:

mitral homograft

bioprosthetics

atrioventricular heart valves

Authors:

Komarov R.N.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-3904-6415

Tsaregorodtsev A.V.

Pirogov Russian National Research Medical University

ORCID: 0000-0001-7181-3779

Nuzhdin M.D.

Chelyabinsk Regional Clinical Hospital

ORCID: 0000-0002-7269-6727

Received:

28.09.2023

Accepted:

19.12.2023

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References:

Acar C, Tolan M, Berrebi, et al. Homograft replacement of the mitral valve: graft selection, technique of implantation, and results in forty-three patients. The Journal of Thoracic and Cardiovascular Surgery. 1996;111(2):367-380. https://doi.org/10.1016/S0022-5223(96)70446-4
Bernhard A, Largiadèr F, Senning Å. Homologe Mitralklappentransplantation. Langenbecks Archiv Für Klinische Chirurgie. 1967;319(1):816-819. https://doi.org/10.1007/bf02659385
Caira FC, Stock SR, Gleason TG, et al. Human degenerative valve disease is associated with up-regulation of low-density lipoprotein receptor-related protein 5 receptor-mediated bone formation. J Am Coll Cardiol. 2006;47:1707-1712.
Heimbecker RO, Aldrige HE, Lemire G. The durability and fate of aortic valve grafts. An experimental study with a long term follow-up of clinical patients. J Cardiovasc Surg (Torino). 1968;9:511-517.
Hoerstrup SP, Sodian R, Daebritz S, et al. Functional living trileaflet heart valves grown in vitro. Circulation. 2000;102(19 Suppl 3):19-44.
Hubka M, Siska K, Brozman M, Holec V. Replacement of mitral and tricuspid valves by mitral homograft. J Thorac Cardiovasc Surg. 1966;51(2):195-204.
Komarov R, Nuzhdin M, Ismailbaev A, Bashmakov N. Clinical Implication of Cardiac Valve Allografts in Rare Surgical Circumstances. IntechOpen. 2023. https://doi.org/10.5772/intechopen.112865
Largiadèr F, Senning A, Träbert E, Rosenmund H. Erfassung der Abstossung von Herzhomotransplantaten [Diagnosis of cardiac homograft rejection]. Helv Chir Acta. 1969;36(3):289-295. (In German).
Livi V, Abdulla AK, Parker R, et al. Viability and morfology of aortic and pulmonary homografts. J Thorac Cardiovasc Surg. 1987;93:755-760.
Malm JR, Bowman FO Jr, Harris PD, Kowalik AT. An evaluation of aortic valve homografts sterilized by electron beam energy. J Thorac Cardiovasc Surg. 1967;54:471-477.
Mitchell GF, Hwang SJ, Vasan RS, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2010;121(4):505-511.
Mizobuchi M, Towler D, Slatopolsky E. Vascular calcification: the killer of patients with chronic kidney disease. J Am Soc Nephrol. 2009;20:1453-1464.
Neumann A, et al. Heart valve engineering: Decellularized allograft matrices in clinical practice. Biomed Tech. 2013;58 (5):453-456.
O’Brien MF, Gerbode F. Homotransplantation of the mitral valve preliminary experimental report and review of literature. ANZ Journal of Surgery. 1964;34(2):81-88. https://doi.org/10.1111/j.1445-2197.1964.tb06204.x
O’Brien MF, Stafford G, Gardner M, et al. The Viable Cryopreserved Allograft Aortic Valve. Journal of Cardiac Surgery. 1987;2(1S):153-167. https://doi.org/10.1111/jocs.1987.2.1s.153
Obadia JF, Raisky O, Sebbag L, et al. Monobloc aorto-mitral homograft as a treatment of complex cases of endocarditis. J Thorac Cardiovasc Surg. 2001;121(3):584-586. https://doi.org/10.1067/mtc.2001.111375
Rastelli GC, Berghuis J, Swan HJ. Evaluation of function of mitral valve after homotransplantation in the dog. J Thorac Cardiovasc Surg. 1965;49:459-474.
Robicsek F, Sanger PW, Taylor FH, Robicsek L. Transplantability of heart valves. Arch Surg. 1962;84:141-148. https://doi.org/10.1001/archsurg.1962.01300190145018
Senning A. Rekonstruktion der Mitralklappe: Homoioplastik [Reconstruction of the mitral valve: homoplasty]. Thoraxchir Vask Chir. 1968;16(6):601-605. (In German). https://doi.org/10.1055/s-0028-1100585
Sievers HH, Lange PE, Yankah AC, et al. Allogeneous transplantation of the mitral valve. An open question. Thorac Cardiovasc Surg. 1985;33(4):227-229. https://doi.org/10.1055/s-2007-1014126
Vanvliet PD, Titus JL, Berghuis J, Ellis FH Jr. Morphologic features of homotransplanted canine mitral valves. J Thorac Cardiovasc Surg. 1965;49:504-510.
Barbarash LS, Zhuravleva IYu. Bioprosthetic heart valve evolution: two decades of advances and challenges. Complex Issues of Cardiovascular Diseases. 2012;(1):4-11. (In Russ.).
Bockeria LA, Sokolskaya MA, Shvartz VA. Modern tendencies in the use of information and telecommunication technologies in the treatment of patients with cardiovascular diseases. Clinical Medicine (Russian Journal). 2020;98(9-10):656-664. (In Russ.). https://doi.org/10.30629/0023-2149-2020-98-9-10-656-664
Britikov DV, Chashchin IS, Khugaev GA, Bakuleva NP. The decellularization of allografts with supercritical carbon dioxide and detergents. Experimental data. The Bulletin of Bakoulev Center. Cardiovascular Diseases. 2019;20(5):402-409. (In Russ.). https://doi.org/10.24022/1810-0694-2019-20-5-402-409
Komarov RN, Nuzhdin MD, Belov VA, et al. Mitral homograft in tricuspid position: indications for implantation and surgical technique. Complex Issues of Cardiovascular Diseases. 2023;12(2):173-182. (In Russ.). https://doi.org/10.17802/2306-1278-2023-12-2-173-182
Komarov RN, Nuzhdin MD, Simonyan AO, et al. Tricuspid valve replacement with a mitral homograft: surgical technique and immediate results. Russian Journal of Cardiology and Cardiovascular Surgery. 2023;16(4):443-448. (In Russ.). https://doi.org/10.17116/kardio202316041443
Nuzhdin MD, Komarov RN, Matsuganov DA, et al. Technical aspects and outcomes of using homografts in atrioventricular valve surgery: a systematic review. Patologiya krovoobrashcheniya i kardiokhirurgiya. 2023;27:42-53. (In Russ.). https://doi.org/10.21688/1681-3472-2023-2-42-53
Ross DN. Homograft replacement of the aortic valve. J Cardiovasc Surg. 1965;Suppl1:89-94.
Britikov DV, Akatov VS, Chashchin IS, et al. Evolution of approaches to viability and devitalization of allografts and development of a new method of decellularization. Cellular modification of allografts. Clinical physiology of blood circulation. 2021;2(18):118-127. (In Russ.). https://doi.org/10.24022/1814-6910-2021-18-2-128-138
Skopin II, Samorodskaya IV, Umarov VM, et al. Immediate and long-term results of surgical treatment of active infective endocarditis of native heart valves in drug-addicted patients. Annals of surgery. 2013;3:35-42. (In Russ.).
Skopin II, Muratov RM, Shamsiev GA, et al. Cryopreserved mitral allografts in surgical treatment of active infectious endocarditis of tricuspid valve. Thoracic and cardiovascular surgery. 1998;5:33-38. (In Russ.).