Efficacy and safety of intravenous ibuprofen for early postoperative analgesia after cardiac surgery

Sorokina L.S.

Petrovsky National Research Center of Surgery

ORCID: 0000-0001-5809-8563

Fomina D.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-3694-9328

Semenkova M.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-6992-1794

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

ORCID: 0000-0001-5809-8563

Efficacy and safety of intravenous ibuprofen for early postoperative analgesia after cardiac surgery

Authors:

Sorokina L.S., Fomina D.V., Semenkova M.A., Eremenko A.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2023;16(3): 291‑296

DOI: 10.17116/kardio202316031291

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To cite this article:

Sorokina LS, Fomina DV, Semenkova MA, Eremenko AA. Efficacy and safety of intravenous ibuprofen for early postoperative analgesia after cardiac surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2023;16(3):291‑296. (In Russ.)
https://doi.org/10.17116/kardio202316031291

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)

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OBJECTIVE

To evaluate the efficacy and safety of intravenous ibuprofen under patient-controlled morphine analgesia in early postoperative period after cardiac surgery.

MATERIAL AND METHODS

Two postoperative analgesia regimens were evaluated in this observational study. The 1st group included 20 patients who were received infusion of ibuprofen 800 mg twice. The 2nd group included 20 patients who were anesthetized by patient-controlled morphine analgesia. Intensity of pain during motor activity was assessed using a 100-mm visual analogue scale (VAS). Inductive spirometry was additional objective criterion of effectiveness of analgesia.

RESULTS

In the 1st group, pain syndrome decreased from 46.75 mm to 24.25 mm (p=0.002) by the end of ibuprofen infusion. This trend continued at all stages, and mean VAS scores did not exceed 25 mm. Since morphine infusion was started 2 hours after tracheal extubation in the 2nd group, pain syndrome significantly decreased only after 4 hours and differed from previous stages. By the end of the first day, pain syndrome did not exceed 20 mm in both groups. Analgesic effect of ibuprofen positively affected the function of external respiration with 1.8-fold increase of maximum inspiratory capacity compared to baseline values. In the 2nd group, high rate of adverse events was associated with morphine and depended on its dose. Daily consumption of morphine per a patient was 12.4 mg and 22.6 mg, respectively (p<0.001).

CONCLUSIONS

Good analgesic and significant opioid-sparing effects, as well as safety of intravenous form of ibuprofen were observed for postoperative anesthesia after cardiac surgery.

Keywords:

postoperative pain after cardiac surgery

opioid analgesics

ibuprofen

patient-controlled analgesia

Authors:

Sorokina L.S.

Petrovsky National Research Center of Surgery

ORCID: 0000-0001-5809-8563

Fomina D.V.

Petrovsky National Research Center of Surgery

ORCID: 0000-0002-3694-9328

Semenkova M.A.

Sechenov First Moscow State Medical University

ORCID: 0000-0002-6992-1794

Eremenko A.A.

Petrovsky National Research Center of Surgery;
Sechenov First Moscow State Medical University

ORCID: 0000-0001-5809-8563

Received:

20.01.2023

Accepted:

16.02.2023

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