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Porembskaya O.Ya.

Mechnikov North-Western State Medical University;
Institute of Experimental Medicine

Toropova Ya.G.

Almazov National Medical Research Center

Lobastov K.V.

Pirogov Russian National Research Medical University

Laberko L.A.

Pirogov Russian National Research Medical University

Kravchuk V.N.

Mechnikov North-Western State Medical University;
Kirov Military Medical Academy

Saiganov S.A.

Mechnikov North-Western State Medical University

Pulmonary artery thrombosis: clinical aspects and mechanism

Authors:

Porembskaya O.Ya., Toropova Ya.G., Lobastov K.V., Laberko L.A., Kravchuk V.N., Saiganov S.A.

More about the authors

Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2021;14(3): 213‑219

DOI: 10.17116/kardio202114031213

Read: 3731 times

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Table of contents

PULMONARY ARTERY THROMBOSIS: CLINICAL ASPECTS AND MECHANISM
PULMONARY ARTERY THROMBOSIS: CLINICAL ASPECTS AND MECHANISM

To cite this article:

Porembskaya OYa, Toropova YaG, Lobastov KV, Laberko LA, Kravchuk VN, Saiganov SA. Pulmonary artery thrombosis: clinical aspects and mechanism. Russian Journal of Cardiology and Cardiovascular Surgery. 2021;14(3):213‑219. (In Russ.)
https://doi.org/10.17116/kardio202114031213

Подписка 2026 Кардиология и сердечно-сосудистая хирургия (Russian Journal of Cardiology and Cardiovascular Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Pulmonary artery thrombosis (PAT) has not yet been determined as a separate nosology. Forcedly hiding behind the diagnosis of pulmonary artery embolism without embolic source, PAT has not been investigated enough as a process with own features of pathogenesis and clinical aspects. This process develops as a part of aggravation of chronic obstructive pulmonary disease, asthma, sickle cell anaemia, etc. PAT can be detected in 85% of patients with traumatic thoracic injuries and in more than 40% of patients with severe viral pneumonia. There are several potential mechanisms underlying PAT including endothelial, thrombocyte and neutrophil activation by systemic inflammation and hypoxia. Thus, we can conclude that local pulmonary artery thrombosis develops independently from pulmonary thromboembolism. However, causes and pathogenesis of PAT still require further research.

Keywords:

pulmonary artery thrombosis
thromboembolism
platelet activation
endothelial activation
NETs

Authors:

Porembskaya O.Ya.

Mechnikov North-Western State Medical University;
Institute of Experimental Medicine

Toropova Ya.G.

Almazov National Medical Research Center

Lobastov K.V.

Pirogov Russian National Research Medical University

Laberko L.A.

Pirogov Russian National Research Medical University

Kravchuk V.N.

Mechnikov North-Western State Medical University;
Kirov Military Medical Academy

Saiganov S.A.

Mechnikov North-Western State Medical University

Received:

10.10.2020

Accepted:

17.11.2020

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References:

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