Age-related aspects of heart remodeling in children after transcatheter correction of atrial septal defect

Shushpannikov P.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Tarasov R.S.

Research Institute for Complex Issues of Cardiovascular Diseases

Sizova I.N.

Research Institute for Complex Issues of Cardiovascular Diseases

Ganyukov V.I.

Research Institute for Complex Issues of Cardiovascular Diseases

Age-related aspects of heart remodeling in children after transcatheter correction of atrial septal defect

Authors:

Shushpannikov P.A., Tarasov R.S., Sizova I.N., Ganyukov V.I.

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Journal: Russian Journal of Cardiology and Cardiovascular Surgery. 2021;14(1): 11‑19

DOI: 10.17116/kardio20211401111

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To cite this article:

Shushpannikov PA, Tarasov RS, Sizova IN, Ganyukov VI. Age-related aspects of heart remodeling in children after transcatheter correction of atrial septal defect. Russian Journal of Cardiology and Cardiovascular Surgery. 2021;14(1):11‑19. (In Russ.)
https://doi.org/10.17116/kardio20211401111

Подписка 2025-2 (Russian Journal of Cardiology and Cardiovascular Surgery)

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OBJECTIVE

To analyze 3-month outcomes and features of heart remodeling (HR) in children of different ages after transcatheter correction of atrial septal defect (ASD).

MATERIAL AND METHODS

A prospective study included 48 children with isolated secondary ASD who underwent endovascular correction from early 2017 to mid-2019. Patients were divided into 2 groups by age. The first (n=24) group — children of preschool age (<8 years old), mean age 3.5 [2.5; 6] years; the second group (n=24) — school age patients (8-18 years), mean age 12 [9.5; 14.5] years. We estimated success of surgery, complications throughout the follow-up period, heart remodeling according to extended echocardiography protocol in in-hospital, 30-day and 3-month follow-up periods.

RESULTS

All children successfully underwent endovascular closure of ASD. No complications were detected. Echocardiography analysis in both groups revealed certain significant changes in indicators and their age-related features indicating a positive HR throughout the follow-up period. Intensive structural and functional changes in heart chambers occurred in both groups throughout 30-day period after transcatheter correction. These processes slowed down by the third month. In school-age children, more significant HR was noted compared to preschool children that was associated with initially more severe abnormal HR in older children without previous ASD correction.

CONCLUSION

Endovascular correction of ASD is an effective and safe method. Early occlusion of septal defect in young children is justified due to less severe and persistent abnormalities compared to older children.

Keywords:

congenital heart defects

atrial septal defect

heart remodeling

endovascular correction

age-related features

Authors:

Shushpannikov P.A.

Research Institute for Complex Issues of Cardiovascular Diseases

Tarasov R.S.

Research Institute for Complex Issues of Cardiovascular Diseases

Sizova I.N.

Research Institute for Complex Issues of Cardiovascular Diseases

Ganyukov V.I.

Research Institute for Complex Issues of Cardiovascular Diseases

Received:

06.07.2020

Accepted:

27.08.2020

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