The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Klyshko N.K.

Far Eastern Federal University, Medical Center, Vladivostok, Russia;
Pacific State Medical University of the Ministry of Health of Russia, Department of ophthalmology and otorhinolaryngology, Vladivostok, Russia

Shchava S.P.

Far Eastern Federal University, Medical Center, Vladivostok, Russia

Furgal A.A.

Far Eastern Federal University, Medical Center, Vladivostok, Russia;
Pacific State Medical University of the Ministry of Health of Russia, Department of ophthalmology and otorhinolaryngology, Vladivostok, Russia

Rapovka V.G.

Pacific State Medical University of the Ministry of Health of Russia, Department of ophthalmology and otorhinolaryngology, Vladivostok, Russia

Shumatov V.B.

Pacific State Medical University, 690002, Vladivostok, Russia

Silaev A.A.

GBUZ "Gorodskaia klinicheskaia bol'nitsa #7 DZM", Moskva

Zenina A.A.

Far Eastern Federal University, Medical Center, Vladivostok, Russia;
Pacific State Medical University of the Ministry of Health of Russia, Department of ophthalmology and otorhinolaryngology, Vladivostok, Russia

Filippova E.A.

Research Center for Obstetrics, Gynecology and Perinatology, Moscow, Russia

Goncharuk R.A.

Tikhookeanskiĭ gosudarstvennyĭ meditsinskiĭ universitet, Vladivostok

Sorokin V.A.

Far Eastern Federal University, Medical Center, Vladivostok, Russia;
Pacific State Medical University of the Ministry of Health of Russia, Department of ophthalmology and otorhinolaryngology, Vladivostok, Russia

Cardioplegia and myocardial protection in adult cardiac surgery: current trends

Authors:

Klyshko N.K., Shchava S.P., Furgal A.A., Rapovka V.G., Shumatov V.B., Silaev A.A., Zenina A.A., Filippova E.A., Goncharuk R.A., Sorokin V.A.

More about the authors

Read: 12378 times


To cite this article:

Klyshko NK, Shchava SP, Furgal AA, et al. . Cardioplegia and myocardial protection in adult cardiac surgery: current trends. Russian Journal of Cardiology and Cardiovascular Surgery. 2020;13(2):108‑113. (In Russ.)
https://doi.org/10.17116/kardio202013021108

Recommended articles:
Opti­mal cardioplegia for coro­nary artery bypass grafting in patients with heart failure: a randomized study. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(4):405-411
Prevention of repe­rfusion injury in cardiac surgery. Russian Journal of Cardiology and Cardiovascular Surgery. 2025;(4):471-477

References:

  1. Chambers DJ, Fallouh HB. Cardioplegia and cardiac surgery: Pharmacological arrest and cardioprotection during global ischemia and reperfusion. . 2010;127(1):41-52.
  2. Hearse DJ, Stewart DA, Braimbridge MV. Myocardial protection during ischemic cardiac arrest. The importance of magnesium in cardioplegic infusates. . 1978;75(6):877-885.
  3. Brown PS, Holland FW, Parenteau GL, Clark RE. Magnesium ion is beneficial in hypothermic crystalloid cardioplegia. . 1991;51(3):359-366; discussion 367.
  4. Yau TM, Ikonomidis JS, Weisel RD, et al. Ventricular function after normothermic versus hypothermic cardioplegia. . 1993;105(5):833-843; discussion 843-4.
  5. Fiore AC, Swartz MT, Nevett R, et al. Intermittent antegrade tepid versus cold blood cardioplegia in elective myocardial revascularization. . 1998;65(6):1559-1564; discussion 1564-5.
  6. Bokeria LA, Volgushev VE, Movsesyan RR, Aybazov RU, Berishvili II, Sigaev IYu. Use of normothermic cardioplegic solution during surgery myocardial revascularization. . 2006;(3):1-9. (In Russ.)
  7. Volgushev VE, Piskun AV, Movsesyan RR, Sigaev IYu. Application of normothermic cardioplegic solution in myocardial revascularization in a patient with a low left ventricle ejection fraction. . 2006;7(5):90-92. (In Russ.)
  8. Muratov RM, Kashtelyan LS, Chizhov AV. Additional myocardial protection by normothermic cardioplegic reperfusion. . 1992;3-4:29-32. Accessed June 28, 2019.
  9. Uyar I, Mansuroǧlu D, Kirali K, et al. Aspartate and glutamate-enriched cardioplegia in left ventricular dysfunction. . 2005;20(4):337-344. 
  10. Ji B, Liu J, Liu M, et al. Effect of cold blood cardioplegia enriched with potassium-magnesium aspartate during coronary artery bypass grafting. . 2006;47(6):671-675.
  11. Yaku H. Is human atrial natriuretic peptide (hANP) effective as an additive to cardioplegic solution during cardiac surgery? . 2011;75(9):2052-2053.
  12. Van Der Baan A, Kortekaas KA, Van Es E, Meier S, Klautz RJM, Engbers FHM. Sevoflurane-enriched blood cardioplegia: The intramyocardial delivery of a volatile anesthetic. . 2015;30(4):295-301. 
  13. Li M, Xue L, Sun H, Xu S. Myocardial Protective Effects of L-Carnitine on Ischemia-Reperfusion Injury in Patients With Rheumatic Valvular Heart Disease Undergoing Cardiac Surgery. . 2016;30(6):1485-1493.
  14. Bignami E, Guarnieri M, Franco A, et al. Esmolol before cardioplegia and as cardioplegia adjuvant reduces cardiac troponin release after cardiac surgery. A randomized trial. . 2017;32(4):313-320. 
  15. Algarni KD, Weisel RD, Caldarone CA, Maganti M, Tsang K, Yau TM. Microplegia during coronary artery bypass grafting was associated with less low cardiac output syndrome: A propensity-matched comparison. . 2013;95(5):1532-1538.
  16. Jynge P, Hearse DJ, Feuvray D, et al. The St. Thomas’ Hospital cardioplegic solution: a characterization in two species. . 1981;30:1-28. Accessed June 20, 2019.
  17. Ledingham SJ, Braimbridge MV, Hearse DJ. The St. Thomas’ Hospital cardioplegic solution. A comparison of the efficacy of two formulations. . 1987;93(2):240-246. Accessed June 20, 2019.
  18. Braimbridge M V, Chayen J, Bitensky L, Hearse DJ, Jynge P, Canković-Darracott S. Cold cardioplegia or continuous coronary perfusion? Report on preliminary clinical experience as assessed cytochemically. . 1977;74(6):900-906. Accessed June 20, 2019.
  19. Cayir MC, Yuksel A. The Use of del Nido Cardioplegia for Myocardial Protection in Isolated Coronary Artery Bypass Surgery. . 2019:1-7. 
  20. Viana FF, Shi WY, Hayward PA, Larobina ME, Liskaser F, Matalanis G. Custodiol versus blood cardioplegia in complex cardiac operations: an Australian experience. . 2013;43(3):526-531. 
  21. Bretschneider H. Myocardial Protection. . 1980;28(05):295-302. 
  22. Gebhard M, Preusse C, Schnabel P, Bretschneider H. Different Effects of Cardioplegic Solution HTK during Single or Intermittent Administration. . 1984;32(05):271-276. 
  23. Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children’s Hospital. . 2012;44(3):98-103. Accessed June 21, 2019.
  24. Vivacqua A, Robinson J, Abbas AE, et al. Single-dose cardioplegia protects myocardium as well as traditional repetitive dosing: A noninferiority randomized study. . May 2019.
  25. Hoyer A, Lehmann S, Mende M, Noack T, Kiefer P, Misfeld M, et al. Custodiol versus cold Calafiore for elective cardiac arrest in isolated aortic valve replacement: a propensity-matched analysis of 7263 patients. . 2017;52:303-309.
  26. Zeng J, He W, Qu Z, Tang Y, Zhou Q, Zhang B. Cold Blood Versus Crystalloid Cardioplegia for Myocardial Protection in Adult Cardiac Surgery: A Meta-analysis of Randomized Controlled Studies. . 2014;28(3):674-681. 
  27. Gaudino M, Pragliola C, Anselmi A, et al. Randomized trial of HTK versus warm blood cardioplegia for right ventricular protection in mitral surgery. . 2013;47(6):359-367. 
  28. Braathen B, Jeppsson A, Scherstén H, et al. One single dose of histidine—tryptophan—ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: A prospective randomized study. . 2011;141(4):995-1001.
  29. Alshibaya MM, Beknazaryan DYu, Volgushev VE, et al. Evaluation of the effectiveness of different methods of intraoperative myocardial protection during coronary artery surgery. . 2006;7(5):60. (In Russ.)
  30. Alshibaya MM, Nisnevich ED, Beknazaryan DYu, et al. Evaluation of the effectiveness of intraoperative myocardial protection using various methods of cardioplegia in coronary artery surgery. . 2006;7(3):144. (In Russ.)
  31. Andreev DB, Sorokin VA, Novikov AYu. Comparative evaluation of methods of crystalloid and blood cold cardioplegia. . 2003;1:41-44. (In Russ.)
  32. Maystrovsky KV, Andreev DB, Sorokin VA. Comparative evaluation of methods pharmachological crystalloid or intermittent blood cardioplegia. . 2003;4(6):118. (In Russ.)
  33. Kuhn E, Liakopoulos O, Slottosch I, et al. Buckberg versus Calafiore Cardioplegia in Patients with Acute Coronary Syndromes. . 2018;66(06):457-463. 
  34. Trescher K, Gleiss A, Boxleitner M, et al. Short-term clinical outcomes for intermittent cold versus intermittent warm blood cardioplegia in 2200 adult cardiac surgery patients. . 2017;58(1):105-112. 
  35. Baig MAR, Sher-I-Murtaza M, Iqbal A, et al. Clinical outcomes of intermittent antegrade warm versus cold blood cardioplegia. . 2015;65(6):593-596. Accessed September 7, 2019.
  36. Fan Y, Zhang A-M, Xiao Y-B, Weng Y-G, Hetzer R. Warm versus cold cardioplegia for heart surgery: a meta-analysis. . 2010;37(4):912-919. 
  37. Mirmohammadsadeghi P, Mirmohammadsadeghi M. Effects of single antegrade hot shot in comparison with no hot shot administration during coronary artery bypass grafting. . 2015;11(3):186-190.
  38. Sanetra K, Gerber W, Shrestha R, et al. The del Nido versus cold blood cardioplegia in aortic valve replacement: A randomized trial. . June 2019.
  39. Ucak HA, Uncu H. Comparison of Del Nido and Intermittent Warm Blood Cardioplegia in Coronary Artery Bypass Grafting Surgery. . 2019;25(1):39-45. 
  40. O’Donnell C, Wang H, Tran P, Miller S, Shuttleworth P, Boyd JH. Utilization of Del Nido Cardioplegia in Adult Coronary Artery Bypass Grafting ― A Retrospective Analysis. . 2019;83(2):342-346. 
  41. Li Y, Lin H, Zhao Y, et al. Del Nido Cardioplegia for Myocardial Protection in Adult Cardiac Surgery. . 2018;64(3):360-367. 
  42. Ad N, Holmes SD, Massimiano PS, Rongione AJ, Fornaresio LM, Fitzgerald D. The use of del Nido cardioplegia in adult cardiac surgery: A prospective randomized trial. . 2018;155(3):1011-1018.
  43. Guajardo Salinas GE, Nutt R, Rodriguez-Araujo G. Del Nido cardioplegia in low risk adults undergoing first time coronary artery bypass surgery. . 2017;32(1):68-73. 
  44. Timek T, Willekes C, Hulme O, et al. Propensity Matched Analysis of del Nido Cardioplegia in Adult Coronary Artery Bypass Grafting: Initial Experience With 100 Consecutive Patients. . 2016;101(6):2237-2241.
  45. Mick SL, Robich MP, Houghtaling PL, et al. Del Nido versus Buckberg cardioplegia in adult isolated valve surgery. . 2015;149(2):626-636.e5. 
  46. Ramanathan R, Parrish DW, Armour TK, Brinster DR. Use of del Nido Cardioplegia in Adult Cardiac Surgery. . 2015 Mar;63(7):624-627. 
  47. Grishin AV, Yavorovsky AG, Zhidkov IL, et al. Adequacy of myocardial protection with cardioplegic Consol solution from reperfusion myocardial damage at different periods of aortic cross-clamping. . 2012;5:1-16. (In Russ.)
  48. Grishin AV, Yavorovsky AG, Charchyan ER, Fedulova SV, Charnaya MA. Pharmacological postconditioning of myocardium with sevoflurane in cardiac patients. . 2016;61(5):348-352. (In Russ.)

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.