Aim — to analyze an efficacy of air-plasma flow (Plazon device) for superficial sternal wound infection management in cardiac surgery. Material and methods. Plazon was used in 7 patients for post-sternotomy wound complications treatment. There were 6 men and 1 woman aged 57.3±10.1 years. All interventions were elective. 3 (42.9%) patients underwent coronary artery bypass surgery, 1 (14.3%) — isolated aortic valve replacement, 2 (28.6%) — simultaneous coronary bypass procedure and aortic valve replacement, 1 (14.3%) — Bentall—deBono procedure. Superficial sternal wound infection developed in 8.3±5.3 days postoperatively. Air-plasma flow was used for local treatment of wound infection. Daily procedure has been started after removal of seams from the skin and subcutaneous fat. Sparing sterilization mode was applied. There were 5.9±0.7 procedures up to secondary closure of the wound followed by paravulnar management with biological stimulation mode (NO-therapy). Mean number of procedures 5.9±1.1 was in postoperative period. Antibacterial therapy was administered up to secondary seams removal (in 14 days after closure of the wound). Drainage tubes were removed at the same day. Results. An effectiveness of Plazon device was evaluated by exudation-to-regeneration transition with appearance of granulations. Granulations islets growth was noted in 3.0±0.6 days after air-plasma flow administration. Complete covering with active granulation tissue was observed after 5.9±0.7 days. Wound microflora was absent in 100% of patients after 5 days. Duration of treatment with air-plasma flow prior to secondary closure of the wound was 6.9±0.7 days. Mean hospital-stay after redo intervention was 6.9±1.1 days. Herewith, paravulnar management with air-plasma flow was performed 5.9±1.1 times in postoperative period. Conclusion. NO-consisting air-plasma flow for superficial sternal infection is possible and reduces the exudation phase, accelerates proliferation phase and shortens treatment before and after secondary closure of the wound.