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Zagaĭnaia E.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Shchekochikhin D.Iu.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Kopylov F.Iu.

Pervyĭ MGMU im. I.M. Sechenova, kafedra profilakticheskoĭ i neotlozhnoĭ kardiologii FPPOV, Moskva

Glazachev O.S.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Syrkin A.L.

Sechenov First Moscow State Medical University

Sazontova T.G.

Pervyĭ Moskovskiĭ gosudarstvennyĭ meditsinskiĭ universitet im. I.M. Sechenova;
Moskovskiĭ gosudarstvennyĭ universitet im. M.V. Lomonosova

Interval hypoxic training in cardiology practice

Authors:

Zagaĭnaia E., Shchekochikhin D.Iu., Kopylov F.Iu., Glazachev O.S., Syrkin A.L., Sazontova T.G.

More about the authors

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To cite this article:

Zagaĭnaia E, Shchekochikhin DIu, Kopylov FIu, Glazachev OS, Syrkin AL, Sazontova TG. Interval hypoxic training in cardiology practice. Russian Journal of Cardiology and Cardiovascular Surgery. 2014;7(6):28‑34. (In Russ.)

References:

  1. Glazachev O.S., Zvenigorodskaya L.А., Dudnik E.N. i dr.Interval'nye gipo-giperoksicheskie trenirovki v lechenii metabolicheskogo sindroma [Interval hypo-hyperoxic training in the treatment of metabolic syndrome]. EHksper i klin gastroehnterol 2010; 7: 51-56.
  2. El'chaninova S.А., Korenyak N.А., Dryagina I.V. (Vyalova I.V.), Makarenko V.V.K mekhanizmu dejstviya interval'noj gipoksicheskoj gipoksii pri lechenii i profilaktike arterial'noj gipertenzii. Estestvoznanie i gumanizm. Sbornik nauchnykh rabot [The mechanism of action of interval hypoxic hypoxia in the treatment and prevention of hypertension. Natural science and humanism. Collection of scientific works]. Tomsk 2004; 1: 1: 9-10.
  3. ZHerebker E.M. Preryvistaya normobaricheskaya gipoksiterapiya v lechenii pozhilykh bol'nykh arterial'noj gipertoniej [Intermittent normobaric hypoxic treatment of elderly patients with hypertension]. Klin gerontol 2005; 11: 70-72.
  4. Korkushko O.V., SHatilo V.B., Ishhuk V.А. EHffektivnost' pe-riodicheskikh gipoksicheskikh trenirovok u pozhilykh bol'nykh s ishemicheskoj bolezn'yu serdtsa [The effectiveness of periodic hypoxic training in elderly patients with coronary heart disease]. Uspekhi gerontol 2010; 3: 476-482.
  5. Makhova G.E. Preryvistaya normobaricheskaya gipoksiterapiya - perspektivnyj i ehffektivnyj nemedikamentoznyj me-tod reabilitatsii bol'nykh s transmural'nym infarktom miokarda. Preryvistaya normobaricheskaya gipoksiterapiya [Intermittent normobaric hypoxic - a promising and effective non-drug methods of rehabilitation of patients with transmural myocardial infarction. Intermittent normobaric hypoxic]. Mezhdunarodnaya akademiya problem gipoksii: Doklady. T.4. M: Bumazhnaya galereya 2005; 75-89.
  6. Mukhin I.V. Diffuzionnaya sposobnost' legkikh u bol'nykh s renopul'monal'nym sindromom i ee dinamika pod vliyani-em adaptatsionnoj terapii [Diffusion capacity of the lungs in patients with renal-pulmonary syndrome and its dynamics under the influence of adaptive therapy]. Ukraїn terap zhurn 2009; 2: 98-101.
  7. Rachok L.V., Dubovik T.А., Bulgak А.G. i dr. Ispol'zovanie preryvistoj normobaricheskojgipoksiterapii v predoperatsionnoj podgotovke k koronarnomu shuntirovaniyu bol'nykh ishemicheskoj kardiomiopatiej [Use of intermittent normobaric hypoxic therapy in preoperative preparation for coronary artery bypass grafting in patients with ischemic cardiomyopathy]. Kardiologiya v Bela-rusi 2011; 4: 28-45.
  8. EHrenburg I.V., Gorbachenkov А.А. Interval'nye gipoksicheskie "trenirovki" pri ishemicheskoj bolezni serdtsa [Interval hypoxic "training" for coronary heart disease]. Hyp Med J 1993; 1: 1: 13-16.
  9. Ainslie P.N., Kolb J.C., Ide K., Poulin M.J. Effects of five nights of normobaric hypoxia on the ventilatory responses to acute hypoxia and hypercapnia. Resp Physiol Neurobiol 2003; 138: 193-204.
  10. Anderson J.D., Honigman B. The effect of altitude-induced hypoxia on heart disease: do acute, intermittent, and chronic exposures provide cardio-protection? High Alt Med Biol 2011; 12: 1: 45-55.
  11. Arkhipenko Yu.V., Sazontova T.G., Tkatchouk E.N., Meerson F.Z. Adaptation to continuous and intermittent hypoxia: role of the active oxygen-dependent system. Adaptation Biology and Medicine. Vol. 1. Eds. B.K. Sharma et al. New Dehli: Narosa Publishing House 1997; 251-259.
  12. Banfi G. Reticulocytes in sports medicine. Sports Med  2008; 38: 3: 187-211.
  13. Basovich S.N. The role of hypoxia in mental development and in the treatment of mental disorders: a review. Biosci Trends 2010; 4: 6: 288-296.
  14. Belyavsky N.N., Kuznetsov V.I., Likhachev S.A. Model of treatment and prevention of transient cerebral ischemic attacks with the use of intermittent normobaric hypoxic therapy. Guidelines No. 6-0102. Minsk 2002.
  15. Berglund B. High-Altitude Training: Aspects of Haematological Adaptation. Sports Med 1992; 14: 5: 289-303.
  16. Bernardi L., Passino C., Serebrovskaya Z., Serebrovskayab T., Appenzeller O. Respiratory and cardiovascular adaptations to progressive hypoxia. Effect of interval hypoxic training. Eur Heart J 2001; 22: 879-887.
  17. Bianchi G., Di Giulio C., Rapino C., Rapino M., Antonucci A., Cataldi A. p53 and p66 Proteins Compete for Hypoxia-Inducible Factor 1 Alpha Stabilization in Young and Old Rat Hearts Exposed to Intermittent Hypoxia. Gerontology 2006; 52: 1: 17-23.
  18. Bobyleva О.V., Glazachev О.S. Some peculiarities of microcirculation in healthy individuals under acute hypoxia and after interval hypoxic training. Human Physiol 2008; 34: 6: 92-99.
  19. Borukaeva I.H. Pathophysiological support of treatment of bronchial asthma by interval hypoxic training and enteral oxygen-therapy. Thesis (Vladikavkaz) 2011.
  20. Borukaeva I.Kh. Effectiveness of hypoxic therapy in patients with chronic obstructive pulmonary Disease. Vopr Kurortol Fizioter Lech Fiz Kult 2009; 2: 16-18.
  21. Bulgak A.G., Ostrovskiy Yu.P., Kolyadko M.G., Rachok L.V., Sidorenko I.V., Belskaya M.I. Methodology of hypoxic training of ischemic cardiomyopathy patients during preparation to coronary artery bypass grafting. Guidelines. Minsk 2010.
  22. Burtscher M., Gatterer H., Szubski C., Pierantozzi E., Faulhaber M. Effects of interval hypoxia on exercise tolerance: special focus on patients with CAD or COPD. Sleep Breath 2009; Publ Med PMID: 19688232-18.
  23. Burtscher M., Haider T., Domej W. et al. Intermittent hypoxia increases exercise tolerance in patients at risk for or with mild COPD. Respir Physiol Neurobiol 2009; 165: 97-103.
  24. Burtscher M., Pachinger O., Ehrenbourg I. et al. Intermittent hypoxia increases exercise tolerance in elderly men with and without coronary artery disease. Int J Cardiol 2004; 96: 247-254.
  25. Calbet J.A., Robach P., Lundby C. The exercising heart at altitude. Cell Mol Life Sci 2009; 66: 22: 3601-3613.
  26. Chen L., Lu X.Y., Li J., Fu J.D., Zhou Z.N., Yang H.T. Intermittent hypoxia protects cardiomyocytes against I/R-induced alterations in Ca2+ homeostasis and contraction via the SR and Na+/Ca2+ exchange mechanisms. Bull Eksp Biol Med 1995; 120: 12: 565-567.
  27. Chiu L.L., Chou S.W., Cho Y.M. et al. Effects of prolonged intermittent hypoxia and exercise training on glucose tolerance and muscle GLUT4 protein expression in rats. J Biomed Sci 2004; 11: 838-846.
  28. Clark S.A., Aughey R.J., Gore C.J., Hahn A.G., Townsend N.E., Kinsman T.A., Chow C.M., McKenna M.J., Hawley J.A. Effects of live high, train low hypoxic exposure on lactate metabolism in trained humans. J Appl Physiol 2004: 96: 517-525.
  29. Consolazio C.F., Nelson R.A., Matoush L.O., Hansen J.E. Energy metabolism at high altitude (3,475 m). J Appl Physiol 1966; 21: 1732-1740.
  30. Cornolo J., Brugiaux J.V., Macarlupu J.-L., Privat C., Leon-Veladre F., Richalet J.-P. Autonomic Adaptations in Andean Trained Participants to a 4220-m Altitude Marathon. Med Sci Sport Exer 2005; 37: 12: 2148-2153.
  31. Donina Zh.A., Lavrova I.N., Tikhonov M.A. Effects of intermittent hypoxic training on orthostatic reactions of the cardiorespiratory system. Bull Exp Biol Med 2008; 145: 6: 661-664.
  32. Elchaninova S.A., Korenyack N.A., Pavlovskaya L.I., Makarenko V.V., Dryagina I.V., Simonova A.G. Towards hypotensive effect mechanisms of intermittent normobaric hypoxia in treatment of arterial hypertension. М: Bumazhnaya Galereya 2005; 33-38.
  33. Elchaninova S.A., Korenyack N.A., Smagina I.V., Pinegin L.Ye., Varshavsky B.Ya. Intermittent hypoxia in the treatment of discirculatoryenchephalothy. Neurol Psych J 2002; 11: 29-32.
  34. Eliseev D.N. Physical nature factors in complex treatment of patients with ischemic heart disease and idiopathic hypertensia. Thesis (Moscow) 2007.
  35. Fedorova A.V., Tsvetkova A.M., Tkachyuk E.N. Interval hypoxic training as a component of obesity treatment. Hyp Med J 2003; 11: 4: 59-63.
  36. Foster G.E., McKenzie D.C., Milsom W.K., Sheel A.W. Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J Physiol 2005; 567: 689-699.
  37. Frese F., Friedmann-Bette B. Effects of Repetitive Training at Low Altitude on Erythropoiesis in 400 and 800 m Runners. Int J Sports Med 2010; 18-38.
  38. Friedmann B., Frese F., Menold E., Kauper F., Jost J., Bärtsch P. Individual variation in the erythropoietic response to altitude training in elite juniorswimmers. Br J Sports Med 2005; 39: 3: 148-153.
  39. Garcia N., Hopkins S.R., Powell F.L. Effects of intermittent hypoxia on the isocapnic hypoxic ventilatory response and erythropoiesis in humans. Respir Physiol 2000; 123: 39-49.
  40. Gore C.J., Hahn A.G., Aughey R.J., Martin D.T., Ashenden M.J., Clark S.A., Garnham A.P., Roberts A.D., Slater G.J., McKenna M.J. Live high: train low increases muscle buffer capacity and submaximal cycling efficiency. Acta Physiol Scand 2001: 173: 275-286.
  41. Gore C.J., Clark S.A., Saunders P.U. Nonhematological mechanisms of improved sea-level performance after hypoxic exposure. Med Sci Sports Exer 2007; 39: 9: 1600-1609.
  42. Grassi B., Marzorati M., Kayser B., Bordini M., Colombini A., Conti M., Marconi C., Cerretelli P. Peak blood lactate and blood lactate vs. workload during acclimatization to 5050 m and in deacclimatization. J Appl Physiol 1996; 80: 685-692.
  43. Grobbee D.E. The era of preventive cardiology. Eur J Prevent Cardiol 2012; 19: 1: 3-4.
  44. Haider T., Casucci G., Linser T. et al. Interval hypoxic training improves autonomic cardiovascular and respiratory control in patients with mild chronic obstructive pulmonary disease. J Hypertens 2009; 27: 8: 1648-1654.
  45. Haufe S., Wiesner S., Engeli S., Luft F.C., Jordan J. Influences of Normobaric Hypoxia Training on Metabolic Risk Markers in Human. Med Sci Sports Exerc 2008; 40: 1939-1944.
  46. Hoppeler H., Klossner S., Vogt M. Training in hypoxia and its effects on skeletal muscle tissue. Scand J Med Sci Sports 2008;18: Suppl: 1: 38-49.
  47. Ignatenko G.A. Modern-day potentials of adaptive medicine. Clin Med (Rus.) 2008; 11: 1: 56-57.
  48. Ishchuk V. Safety and efficacy of intermittent normobaric hypoxia training in elderly patients with ischemic heart disease. J Ukrain Acad Med Sci 2007; 13: 374-384-41.
  49. Juel C., Lundby C., Sander M., Calbet J.A.L, van Hall G. Human skeletal muscle and erythrocyte proteins involved in acid-base homeostasis. Adaptations to chronic hypoxia. J Physiol 2003; 548: 639-648.
  50. Kalachev A.G., Elchaninova S.A., Philippova A.G., Korenyak N.A., Dryagina I.V., Makarova I.N. Long-term hypoxic training method in secondary prevention of ischemic heart disease. Vestnik Aritmol 2004; 35-43.
  51. Katayama K., Ishida K., Iwasaki K., Miyamura M. Effect of two durations of short-term intermittent hypoxia on ventilatory chemo-sensitivity in humans. Eur J Appl Physiol 2009; 105: 815-821.
  52. Katayama K., Sato K., Matsuo H., Ishida K., Iwasaki K., Miyamura M. Effect of intermittent hypoxia on oxygen uptake during submaximal exercise in endurance athletes. Eur J Appl Physiol 2004; 92: 75-83.
  53. Koistinen P.O., Rusko H., Rajamaki A., Sarparanta J.K. Epo, red cells, and serum transferrin receptor in continuous and intermittent hypoxia. Med Sci Sports Exerc 2000; 32: 4: 32: 4: 800-804.
  54. Kondrykinskaya I.I., Tkachuk E.N., Erenburg I.V., Gorbachenkov A.A., Lyapkov B.G. Influence of interval hypoxic training on lipid interchange of patients with primary hypercholesterolemia. Hyp Med J 1993; 1: 2: 16-21.
  55. Krivoschekov S.I., Tszo N., Neshumova T.V., Kuzovleva T.S., Kuznetsov O.M. Influence of ten sessions of interval hypoxic training on effectiveness of respiratory metabolism and the lipid level in blood of patients with angina in health resort treatment. Hyp Med 1996; 4: 1: 14-15.
  56. Kudaev M.T., Alieva S.B. Pre-dosed hypoxia in rehabilitation of patients with chronic cardiac failure. Clin Phys Blood Circulat (Makhachkala) 2008; 2: 55.
  57. Kupper T., Miledge J., Hiilerbrandt D., Kubalova J., Hefti U., Basnyat B., Giesler U., Pullan R., Schofl V. Work in hypoxic conditions-consensus statement of the Medical Commission of the Union Internationale des Associations d'Alpinisme (UIAA MedCom). Ann Occup Hyg 2011; 55: 4: 369-386.
  58. Kuznetsov V., Belyavsky N. Mechanisms of the therapeutic action of intermittent hypoxic training in patients suffering from transient ischemia attacks on the background of arterial hypertension and cerebral atherosclerosis. Reports Intern Acad Hyp Probl 2005; 4: 48-54.
  59. Lei Xi, Serebrovskaya T.V. Intermittent hypoxia: from molecular mechanisms to clinical applications. Nova Sci Publ 2009.
  60. Lukyanova L.D., Ushakov I.B. Hypioxia issues: molecular, physiological and medical aspects. Istoki 2004.
  61. Lundby C., Nielsen T.K., Dela F., Damsgaard R. The influence of intermittent altitude exposure to 4.100 m on exercise capacity and blood variables. Scand J Med Sci Sports 2005; 15: 182-187.
  62. Lundby C., van Hall G. Substrate utilization in sea level residents during exercise in acute and after 4 weeks acclimatization to 4100 m. Acta Physiol Scand 2002: 176: 195-201.
  63. Lyamina N.P., Lyamina S.V., Senchiknin V.N., Mallet R.T., Downey H.F., Manukhina E.B. Normobaric hypoxia conditioning reduces blood pressure and normalizes nitric oxide synthesis in patients with arterial hypertension. J Hypertens 2001; 29: 11: 2265-2272.
  64. Lyapkov B.G., Kondrykinskaya I.I., Erenburg I.V., Gorbachen-kov A.A. About mechanisms of influence of interval hypoxic training on cholesterol and triglyceride exchange in primary hypercholesterolemia. Hyp Med J 1993; 1: 4: 12-14.
  65. Mackenzie R.W., Watt P.W., Maxwell N.S. Acute normobaric hypoxia stimulates erythropoietin release. High Alt Med Biol 2008; 9: 1: 28-37.
  66. Maher J.T., Jones L.G., Hartley L.H. Effects of high-altitude exposure on submaximal endurance capacity of men. J Appl Physiol 1974; 37: 895-898.
  67. Makarenko V.V. Role of endothelium in reaction mechanism to intermittent normobaric hypoxia. Thesis (Barnaul) 2009.
  68. Makhova G.E. Intermittent normobaric hypoxia as an advanced effective drug-free rehabilitation method for patients with transmural myocardial infarction. Intermittent normobaric hypoxic therapy: Reports of International Academy of Problems Of Hypoxia. Vol. IV. M: Bumazhnaya Gallereya 2005; 75-89.
  69. Manukhina E.B., Jasti D., Vanin A.F., Downey H.F. Intermittent hypoxia conditioning prevents endothelial dysfunction and improves nitric oxide storage in spontaneously hypertensive rats. Exp Biol Med (Maywood) 2011; 236: 7: 867-873.
  70. Mazzeo R.S. Physiological responses to exercise at altitude: an update. Sports Med 2008; 38: 1:1-8.
  71. Melissa L., MacDougall J.D., Tarnopolsky M.A., Cipriano N., Grinn H.J. Skeletal muscle adaptations to training under normobaric hypoxic versus normoxic conditions. Med Sci Sports Exerc 1997; 29: 2: 238-243.
  72. Millet G.P., Roels B., Schmitt L., Woorons X., Richalet J.P. Combining Hypoxic Methods for Peak Performance. Sports Med 2010; 40: 1-25.
  73. Mounier R., Pialoux V., Roels B., Thomas C., Millet G., Mercier J., Coudert J., Fellmann N., Clottes E. Effect of intermittent hypoxic training on HIF gene expression in human skeletal muscle and leukocytes. Eur J Appl Physiol 2009; 105: 4: 515-524.
  74. Mounier R., Pialoux V., Schmitt L., Richalet J.P., Robach P., Coudert J., Clottes E., Fellmann N. Effects of acute hypoxia tests on blood markers in high-level endurance athletes. Eur J Appl Physiol 2009; 106: 5: 713-720.
  75. Mukharliamov F.Iu., Smirnova M.I., Bedritski S.A., Liadov K.V. Interval hypoxic training in arterial hypertension. Vopr Kurortol Fizioter Lech Fiz Kult 2006; 2: 5-6.
  76. Neya M., Enoki T., Kumai Y., Sugoh T., Kawahara T. The effects of nightly normobaric hypoxia and high intensity training under intermittent normobaric hypoxia on running economy and hemoglobin mass. J Appl Physiol 2007;103: 3: 828-834.
  77. Nishiwaki M., Kawakami R., Saito K., Tamaki H., Takekura H., Ogita F. Vascular adaptations to hypobaric hypoxic training in postmenopausal women. J Physiol Sci 2011; 61: 2: 83-91.
  78. Padilla J., Hamilton S.A., Lundgren E.A., McKenzie J.M., Mickleborough T.D. Exercise training in normobaric hypoxia: is carbonic anhydrase III the best marker of hypoxia? J Appl Physiol 2007;103: 2: 730-732.
  79. Pescador N., Villar D., Cifuentes D., Garcia-Rocha M., Ortiz-Barahona A., Vazquez S., Ordoñez A., Cuevas Y., Saez-Morales D., Garcia-Bermejo M.L., Landazuri M.O., Guinovart J., del Peso L. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase. PLoS One 2010; 12; 5: 3: e9644.
  80. Poole D.C., Schaffartzik W., Knight D.R., Derion T., Kennedy B., Guy H.J., Prediletto R., Wagner P.D. Contribution of exercising legs to the slow component of oxygen uptake kinetics in humans. J Appl Physiol 1991; 71: 1245-1260.
  81. Potievskaya V.A. Use of adaptation to intermittent normobaric hypoxia for increasing of non-specific resistance in treatment of internal organs. Thesis 2004.
  82. Robach P., Schmitt L., Brugniaux J.V., Roels B., Millet G., Hellard P., Nicolet G., Duvallet A., Fouillot J.P., Moutereau S., Lasne F., Pialoux V., Olsen N.V., Richalet J.P. Living high-training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers. Eur J Appl Physiol 2006; 96: 4: 423-433.
  83. Roberts A.C., Butterfield G.E., Cymerman A., Reeves J.T., Wolfel E.E., Brooks G.A. Acclimatization to 4,300 m altitude decreases reliance of fat as a substrate. J Appl Physiol 1996; 81: 1762-1771.
  84. Rodriguez F.A., Ventura J.L., Casas M., Casas H., Pages T., Rames R., Ricart A., Palacios L., Viscor G. Erythropoietin acute reaction and haematological adaptations to short, intermittent hypobaric hypoxia. Eur J Appl Physiol 2002: 82: 170-177.
  85. Roels B., Thomas C., Bentley D.J., Mercier J., Hayot M., Millet G. Effects of intermittent hypoxic training on amino and fatty acid oxidative combustion in human permeabilized muscle fibers. J Appl Physiol 2007; 102: 1:79-86.
  86. Sazontova T., Arkhipenko Yu. Intermittent Hypoxia in Resistance of Cardiac Membrane Structures: Role of Reactive Oxygen Species and Redox Signaling. Intermittent Hypoxia: from Molecular Mechanisms to Clinical Applications. Eds. L. Xi, T.Serebrovskaya 2011; 15: 113-150.
  87. Sazontova T.G., ArkhipenkoYu.V. The role of free radical proteins in adaptation to changing oxygen levels. Problems of hypoxia: molecular, physiological and clinical aspects. Eds. L.D. Lukyanova, I.B. Ushakov. М: Istoki Press 2004; 112-137.
  88. Sazontova T.G., ArkhipenkoYu.V., Meerson F.Z. Adaptation to intermittent hypoxia and PUFA n-3-enricheddietascardioprotectivetoolsincreasing the resistance of the myocardial sarcoplasmic reticulum Са-transport system to free radical oxidation. Bull Exp Biol Med 1995; 120: 7: 42-45.
  89. Schmutz S., Däpp C., Wittwer M., Durieux A.C., Mueller M., Weinstein F., Vogt M., Hoppeler H., Flueck M. A Hypoxia Complement Differentiates the Muscle Response to Endurance Exercise. Exp Physiol 2010; 22-80.
  90. Serebrovskaya T.V., Nikolsky I.S., Nikolska V.V., Mallet R.T., Ishchuk V.A. Intermittent hypoxia mobilizes haematopoietic progenitors and augments cellular and humoral elements of innate immunity in adults. High Alt Med Biol 2011;12: 3: 243-252.
  91. Sheel A.W., MacNutt M.J., Querido J.S. The pulmonary system during exercise in hypoxia and the cold. Exp Physiol 2010; 95: 3: 422-430.
  92. Sokolov E.I., Mushinskaya K.V., Davydov A.L., Starkova N.T., Erenbiurg I.V., Tlachuk E.N. Influence of interval hypoxic training on lipid peroxidation in case of insulin-independent diabetes mellitus. Hyp Med J 1999; 7: 3-4: 37-40.
  93. Stepanov V.K., Dvornikov M.V., Mayev E.Z., Emelyanov B.N., Kozyrev P.V., Vinogradov N.V., Kozyreva E.P. Normobaric interval hypoxic therapy and dosed oxygenation in pulmonology. Intermittent normobaric hypoxic therapy: Proceedings Internat. Acad Probl hypoxia. М: Bumazhnaya Galereya 2005; 4: 154-163.
  94. Stowe A.M., Altay T., Freie A.B., Gidday J.M. Repetitive hypoxia extends endogenous neurovascular protection for stroke. Ann Neurol 2011; 69: 6: 975-985.
  95. Tin'kov A.N., Aksenov V.A. Effects of Intermittent Hypobaric Hypoxia on Blood Lipid Concentrations in Male Coronary Heart Disease Patients. High Altit Med Biol 2002; 3: 3: 277-282.
  96. Tiollier E., Schmitt L., Burnat P., Fouillot J.P., Robach P., Filaire E., Guezennec C., Richalet J.P. Living high-training low altitude training: effects. on mucosal immunity. Eur J Appl Physiol 2005; 94: 3: 298-304.
  97. Townsend N.E., Gore C.J., Hahn A.G. et al. Living high-training low increases hypoxic ventilatory response of well-trained endurance athletes. J Appl Physiol 2002; 93: 1498-1505.
  98. Valle M., García-Godos F., Woolcott O.O. et al. Improvement of myocardial perfusion in coronary patients after intermittent hypobaric hypoxia. J Nucl Cardiol 2006; 13: 69-74.
  99. Wilber R.L. Application of altitude/hypoxic training by elite athletes. Med Sci Sports Exerc 2007; 396: 9: 1610-1624.
  100. Zhang Y., Hu Y., Wang F. Effects of a 28-day "living high-training low" on T-lymphocyte subsets in soccer players. Int J Sports Med 2007; 28: 4: 354-358.

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