The Association of Single Nucleotide Polymorphisms with the Risk of Varicose Veins of the Lower Extremities: A Study of the Russian Population of the Russian Federation

Shadrina A.S.; Smetanina M.A.; Sevost'ianova K.S.; Sokolova E.A.; Shevela A.I.; Soldatsky E.Yu.; Seliverstov E.I.; Demekhova M.Yu.; Shonov O.A.; Iliukhin E.A.; Voronina E.N.; Pikalov I.V.; Zolotukhin I.A.; Kirienko A.I.; Filipenko M.L.

doi:https://doi.org/10.17116/flebo201610268-74

Shadrina A.S.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Smetanina M.A.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia

Sevost'ianova K.S.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Sokolova E.A.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Shevela A.I.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

ORCID: 0000-0002-3164-9377

Soldatsky E.Yu.

Department of Intermediate Level Surgery No1, Faculty of General Medicine, N.I. Pirogov Russian National Research Medical University, Moscow

Seliverstov E.I.

Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia

SPIN RSCI: 9011-1989
Scopus AuthorID: 24332884500
ORCID: 0000-0002-9726-4250

Demekhova M.Yu.

Medalp Ltd, Sankt-Petersburg

Shonov O.A.

Medalp Ltd, Sankt-Petersburg

Iliukhin E.A.

Sankt-Peterburg

Voronina E.N.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Pikalov I.V.

Novosibirsk State Medical University, Novosibirsk, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

Kirienko A.I.

Russian National Research Medical University nabbed after N.I. Pirogov, Moscow, Russia

SPIN RSCI: 8319-5682
Scopus AuthorID: 7007011716
ResearcherID: AAA-5162-2019
ORCID: 0000-0001-8792-1694

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

The Association of Single Nucleotide Polymorphisms with the Risk of Varicose Veins of the Lower Extremities: A Study of the Russian Population of the Russian Federation

Authors:

Shadrina A.S., Smetanina M.A., Sevost'ianova K.S., Sokolova E.A., Shevela A.I., Soldatsky E.Yu., Seliverstov E.I., Demekhova M.Yu., Shonov O.A., Iliukhin E.A., Voronina E.N., Pikalov I.V., Zolotukhin I.A., Kirienko A.I., Filipenko M.L.

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Journal: Journal of Venous Disorders. 2016;10(2): 68‑76

DOI: 10.17116/flebo201610268-74

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To cite this article:

Shadrina AS, Smetanina MA, Sevost'ianova KS, et al. . The Association of Single Nucleotide Polymorphisms with the Risk of Varicose Veins of the Lower Extremities: A Study of the Russian Population of the Russian Federation. Journal of Venous Disorders. 2016;10(2):68‑76. (In Russ.)
https://doi.org/10.17116/flebo201610268-74

Подписка 2026 Флебология (Journal of Venous Disorders)

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Abstract:

Objective — to study the association of polymorphic genetic loci with the risk of varicose veins of lower extremities (VVLE) in ethnic Russians living in the Russian Federation. Single nucleotide polymorphisms (SNPs) in the AGGF1, HFE, MTHFR, MTR and FOXC2 genes were selected for analysis. Material and methods. The study group consisted of 474 patients presenting with varicose vein disease of the lower extremities and included 146 (30,8%) men and 328 (69,2%) women (median age 48 years). 333 (70,3%) patients had a family history of varicose veins; 124 (26,2%) patients did not have a family history of this pathology; 17 (3,6%) patients did not provide information about family history. For the analysis of the association of polymorphisms in the FOXC2 and AGGF1 genes, a control group comprising 478 otherwise healthy individuals without a history of chronic venous disease was formed. In included 147 (30,8%) men and 331 (69,2%) women of the median age 55 years. When studying the HFE gene polymorphisms, a population sample of 764 individuals — 237 (31,0%) men and 527 (69,0%) women (median age 32 years) served as a control group. When investigating the effects of SNPs in the MTHFR and MTR genes, we also used a population-based control group of 896 individuals — 271 (30,2%) men and 625 (69,8%) women (median age 44 years). Genotyping was performed using the real-time polymerase chain reaction. Results. Polymorphisms in the angiogenic factor gene (AGGF1 rs13155212 and rs7704267) and folate-metabolizing genes (MTHFR C677T and MTR A2756G) were not associated with the risk of varicose veins of lower extremities in our study. We revealed an association of rare polymorphism rs1800562 G>A in the HFE gene which can lead to excessive iron accumulation with the increased prevalence of the pathology of interest. In addition,, evidence was obtained that rs1035550 C>T and rs34221221 T>C SNPs in the FOXC2 gene influence the risk of varicose veins. Nevertheless, none of the revealed associations remained statistically significant after correction for multiple testing. It could probably be due to a limited sample size. Conclusion. This study is one of the first attempts to study genetics of varicose veins in Russia. Its results allow the prospects for the further investigation to be outlined.

Keywords:

varicose veins of lower extremities

single nucleotide polymorphism

association

Authors:

Shadrina A.S.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Smetanina M.A.

Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia

Sevost'ianova K.S.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Sokolova E.A.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

Shevela A.I.

The Center of New Medical Technologies Institute of Chemical Biology and Fundamental Medicine, The Russian Academy of Sciences, Siberian Branch Novosibirsk, Russia

ORCID: 0000-0002-3164-9377

Soldatsky E.Yu.

Department of Intermediate Level Surgery No1, Faculty of General Medicine, N.I. Pirogov Russian National Research Medical University, Moscow

Seliverstov E.I.

Russian National Research Medical University named after N.I. Pirogov, Moscow, Russia

SPIN RSCI: 9011-1989
Scopus AuthorID: 24332884500
ORCID: 0000-0002-9726-4250

Demekhova M.Yu.

Medalp Ltd, Sankt-Petersburg

Shonov O.A.

Medalp Ltd, Sankt-Petersburg

Iliukhin E.A.

Sankt-Peterburg

Voronina E.N.

Institut khimicheskoĭ biologii i fundamental'noĭ meditsiny SO RAN, Novosibirsk

Pikalov I.V.

Novosibirsk State Medical University, Novosibirsk, Russia

Zolotukhin I.A.

Pirogov Russian National Research Medical University, Moscow, Russia

SPIN RSCI: 3426-2981
Scopus AuthorID: 8312153900
ResearcherID: P-5001-2016
ORCID: 0000-0002-6563-0471

Kirienko A.I.

Russian National Research Medical University nabbed after N.I. Pirogov, Moscow, Russia

SPIN RSCI: 8319-5682
Scopus AuthorID: 7007011716
ResearcherID: AAA-5162-2019
ORCID: 0000-0001-8792-1694

Filipenko M.L.

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;
Novosibirsk State University, Novosibirsk, Russia

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References:

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