Objective. To study the influence of the compression treatment on the clinical manifestations and venous hemodynamics of the pelvis in the patients presenting with varicose disease of the pelvis (VDP). Material and methods. The present prospective study of the various options and modes of compression treatment was carried out with the participation of 74 patients with VDP during the period from 2008 to 2015. The patients were divided into three groups. The first group consisted of 48 patients with symptoms of VDP and chronic pelvic pain (CPP). They used Class II compression shorts. The second group was made up of 14 patients with VDP and vulvar varicosities without pelvic pain; they used Class II compression shorts. In the third group 12 women with VDP and CPP used only Class II compression stockings. The treatment continued 14 days. The clinical criterion for the evaluation of the effectiveness of the compression treatment was the change of severity of pelvalgia. Radionuclide phlebography (RP) and emission computed tomography (ECT) with the use of the in vivo labelled red blood cells were performed for the reference evaluation of the results of the treatment. Results. Group 1: Wearing the compression shorts produced beneficial effect on the course of the disease in 81,3% of the patients. Pelvic pain decreased from 6,4±1,6 to 1,2±0,7 points. Coefficient of varicose disease of the pelvis (Cvdp) decreased from 1,73±0,32 up to 1,12±0,27 (p<0.05). Such positive effect was absent in 18.8% of the patients. Group 2: The results of RP gave evidence of the acceleration of blood outflow from the lower extremities and the reduction of insufficiency of perforating veins. Mean radionuclide transit time in the tendon, muscle pump parts, popliteal vein in all the patients was 23,6±2,2 sec 29,6±3,4 sec, 32,3±4,2 sec respectively before the treatment and decreased to 16,4±3,1 sec, 22,1±2,5 sec, 25,7±1,9 sec after the treatment (p <0,05). Group 3: The patients experienced no significant influence of the use of Class II compression stockings on the clinical manifestations of VDP; Cvdp also remained unaltered. Conclusion. The present study has demonstrated the efficiency of wearing Class II compression shorts for the treatment of the patients presenting with isolated extension of intrapelvic venous plexuses. Also, Class II compression stockings Class II do not produce any effect on the clinical manifestations of varicose disease of the pelvis.