Traditional methods of obtaining a lung biopsy are surgical biopsy, which is considered the gold standard, but is associated with significant complications and mortality, and transbronchial forceps biopsy, which is a less invasive, but also significantly less informative method in terms of the quality of the material obtained. In recent years, methods have been developed that are also based on transbronchial sampling of lung tissue biopsies, but which make it possible to obtain higher quality material for research, both in volume and in structural state. The most informative of them is transbronchial needle cryobiopsy under endosonography control and various modifications of this method, including domestic ones. However, the capabilities of this method and its modifications for optimal use require analysis, which has not been carried out. For this purpose, an analysis of relevant literature data was carried out, including open sources on patents and the ClinicalTrials.gov website, as well as original studies and review papers found in the PubMed, Embase, Cochrane, and Index Medicus databases. As a result, transbronchial needle cryobiopsy under endosonography control and various methods of its use were assessed, their potential for effectiveness and the presence of significant novelty was reflected, and the feasibility and prospects for use were determined. In conclusion, the high information content of transbronchial needle cryobiopsy under the control of endosonography, its significant predominance over transbronchial forceps biopsy, the presence of positive technical solutions in some ways of using this method and the absence of such in others, the feasibility and prospects for its improvement, including through standardization, are noted.