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Kosyi V.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;
Federal Research and Clinical Center of Federal Medical-Biologic Agency

Astakhov D.A.

Federal Research and Clinical Center of Specialized types of Medical Care and Medical Technologies of FMBA of Russia;
Evdokimov Moscow State University of Medicine and Dentistry

Ivanov Yu.V.

Federal Scientific and Clinical Center for Specialized Medical Service and Medical Technologies;
Leading Researcher at Central Research Institute of Tuberculosis

Panchenkov D.N.

Yevdokimov Moscow State University of Medicine and Dentistry of the Russian Federation

Shift mechanisms of the immune response in open and laparoscopic surgeries

Authors:

Kosyi V.V., Astakhov D.A., Ivanov Yu.V., Panchenkov D.N.

More about the authors

Journal: Endoscopic Surgery. 2021;27(2): 59‑64

DOI: 10.17116/endoskop20212702159

Read: 1197 times

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Table of contents

SHIFT MECHANISMS OF THE IMMUNE RESPONSE IN OPEN AND LAPAROSCOPIC SURGERIES
SHIFT MECHANISMS OF THE IMMUNE RESPONSE IN OPEN AND LAPAROSCOPIC SURGERIES

To cite this article:

Kosyi VV, Astakhov DA, Ivanov YuV, Panchenkov DN. Shift mechanisms of the immune response in open and laparoscopic surgeries. Endoscopic Surgery. 2021;27(2):59‑64. (In Russ.)
https://doi.org/10.17116/endoskop20212702159

Подписка 2026 Эндоскопическая хирургия (Endoscopic Surgery)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

A review of the literature on the mechanisms of changing the immune response in open and laparoscopic operations is presented. The results of the study of the impact of surgical access methods on the immune response at the cytokine cascade, cellular immunity and genetic level are considered. Most studies show the advantage of laparoscopic access in terms of innate immune response, especially in the first postoperative hours, and cellular immunity seems to be suppressed less in minimally invasive surgery than in open access.

Keywords:

surgical stress
immune response
laparoscopic surgeries

Authors:

Kosyi V.V.

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov;
Federal Research and Clinical Center of Federal Medical-Biologic Agency

Astakhov D.A.

Federal Research and Clinical Center of Specialized types of Medical Care and Medical Technologies of FMBA of Russia;
Evdokimov Moscow State University of Medicine and Dentistry

Ivanov Yu.V.

Federal Scientific and Clinical Center for Specialized Medical Service and Medical Technologies;
Leading Researcher at Central Research Institute of Tuberculosis

Panchenkov D.N.

Yevdokimov Moscow State University of Medicine and Dentistry of the Russian Federation

Received:

21.07.2020

Accepted:

26.11.2020

Close metadata

References:

  1. Beutler B. Innate immunity: an overview. Mol Immunol. 2004;40(12):845-859.  https://doi.org/10.1016/j.molimm.2003.10.005
  2. Petrov RV, Khaitov RM, Chereshnev VA. Fiziologiya immunnoi sistemy: kletochnye i molekulyarno-biologicheskie mekhanizmy. Vestnik Rossiiskogo fonda fundamental’nykh issledovanii. 2017;(S1). (In Russ.).
  3. Neher MD, Weckbach S, Flierl MA, Huber-Lang MS, Stahel PF. Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the «bad guy»? J Biomed Scie. 2011;18(1):90.  https://doi.org/10.1186/1423-0127-18-90
  4. Stahel PF, Smith WR, Moore EE. Role of biological modifiers regulating the immune response after trauma. Injury. 2007;38(12):1409-1422. https://doi.org/10.1016/j.injury.2007.09.023
  5. Matzinger P. The danger model: a renewed sense of self. Science. 2002;296(5566):301-305.  https://doi.org/10.1126/science.1071059
  6. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675-680.  https://doi.org/10.1038/90609
  7. Khaitov RM, Pashchenkov MV, Pinegin BV. Rol’ patternraspoznayushchikh retseptorov vo vrozhdennom i aktivnom immunitete. Immunologiya. 2009;30(1). (In Russ.).
  8. Cheron A, Floccard B, Allaouchiche B, Guignant C, Poitevin F, Malcus C, Crozon J, Faure A, Guillaume C, Marcotte G, Vulliez A, Monneuse O, Monneret G. Lack of recovery in monocyte human leukocyte antigen-DR expression is independently associated with the development of sepsis after major trauma. Crit Care. 2010;14(6):R208  https://doi.org/10.1186/cc9331
  9. Horgan AF, Mendez MV, O’Riordain DS, Holzheimer RG, Mannick JA, Rodrick ML. Altered gene transcription after burn injury results in depressed T-lymphocyte activation. Ann Surg. 1994;220(3):342-351; discussion 351-352.  https://doi.org/10.1097/00000658-199409000-00010
  10. Faist E, Schinkel C, Zimmer S, Kremer JP, Von Donnersmarck GH, Schildberg FW. Inadequate interleukin-2 synthesis and interleukin-2 messenger expression following thermal and mechanical trauma in humans is caused by defective transmembrane signalling. J Trauma. 1993;34(6):846-853; discussion 853-854.  https://doi.org/10.1097/00005373-199306000-00016
  11. Heidecke CD, Weighardt H, Hensler T, Bartels H, Holzmann B. [Immune paralysis of T-lymphocytes and monocytes in postoperative abdominal sepsis. Correlation of immune function with survival]. Chirurg. 2000;71(2):159-165.  https://doi.org/10.1007/s001040050028
  12. ERAS Compliance Group. The Impact of Enhanced Recovery Protocol Compliance on Elective Colorectal Cancer Resection: Results From an International Registry. Ann Surg. 2015;261(6):1153-1159. https://doi.org/10.1097/SLA.0000000000001029
  13. Gustafsson UO, Tiefenthal M, Thorell A, Ljungqvist O, Nygrens J. Laparoscopic-assisted and open high anterior resection within an ERAS protocol. World J Surg. 2012;36(5):1154-1161. https://doi.org/10.1007/s00268-012-1519-y
  14. Yang Z-F, Wu D-Q, Wang J-J, Lv Z-J, Li Y. Short- and long-term outcomes following laparoscopic vs open surgery for pathological T4 colorectal cancer: 10 years of experience in a single center. World J Gastroenterol. 2018;24(1):76-86.  https://doi.org/10.3748/wjg.v24.i1.76
  15. Yamamoto S, Hinoi T, Niitsu H, Okajima M, Ide Y, Murata K, Akamoto S, Kanazawa A, Nakanishi M, Naitoh T, Kanehira E, Shimamura T, Suzuka I, Fukunaga Y, Yamaguchi T, Watanabe M, Japan Society of Laparoscopic Colorectal Surgery. Influence of previous abdominal surgery on surgical outcomes between laparoscopic and open surgery in elderly patients with colorectal cancer: subanalysis of a large multicenter study in Japan. J Gastroenterol. 2017;52(6):695-704.  https://doi.org/10.1007/s00535-016-1262-5
  16. Li J, Guo H, Guan X-D, Cai C-N, Yang L-K, Li Y-C, Zhu Y-H, Li P-P, Liu X-L, Yang D-J. The impact of laparoscopic converted to open colectomy on short-term and oncologic outcomes for colon cancer. J Gastrointest Surg. 2015;19(2):335-343.  https://doi.org/10.1007/s11605-014-2685-z
  17. Hinoi T, Kawaguchi Y, Hattori M, Okajima M, Ohdan H, Yamamoto S, Hasegawa H, Horie H, Murata K, Yamaguchi S, Sugihara K, Watanabe M, Japan Society of Laparoscopic Colorectal Surgery. Laparoscopic versus open surgery for colorectal cancer in elderly patients: a multicenter matched case-control study. Ann Surg Oncol. 2015;22(6):2040-2050. https://doi.org/10.1245/s10434-014-4172-x
  18. Hildebrandt U, Kessler K, Plusczyk T, Pistorius G, Vollmar B, Menger MD. Comparison of surgical stress between laparoscopic and open colonic resections. Surg Endosc. 2003;17(2):242-246.  https://doi.org/10.1007/s00464-001-9148-9
  19. Straatman J, Cuesta MA, Tuynman JB, Veenhof AAFA, Bemelman WA, van der Peet DL. C-reactive protein in predicting major postoperative complications are there differences in open and minimally invasive colorectal surgery? Substudy from a randomized clinical trial. Surg Endosc. 2018;32(6):2877-2885. https://doi.org/10.1007/s00464-017-5996-9
  20. Schiphorst AHW, Verweij NM, Pronk A, Borel Rinkes IHM, Hamaker ME. Non-surgical complications after laparoscopic and open surgery for colorectal cancer — A systematic review of randomised controlled trials. Eur J Surg Oncol. 2015;41(9):1118-1127. https://doi.org/10.1016/j.ejso.2015.04.007
  21. Ramanathan ML, MacKay G, Platt J, Horgan PG, McMillan DC. The impact of open versus laparoscopic resection for colon cancer on C-reactive protein concentrations as a predictor of postoperative infective complications. Ann Surg Oncol. 2015;22(3):938-943.  https://doi.org/10.1245/s10434-014-4065-z
  22. Pedrazzani C, Moro M, Mantovani G, Lazzarini E, Conci S, Ruzzenente A, Lippi G, Guglielmi A. C-reactive protein as early predictor of complications after minimally invasive colorectal resection. J Surg Res. 2017;210:261-268.  https://doi.org/10.1016/j.jss.2016.11.047
  23. Hu J-K, Zhou Z-G, Chen Z-X, Wang L-L, Yu Y-Y, Liu J, Zhang B, Li L, Shu Y, Chen J-P. Comparative evaluation of immune response after laparoscopical and open total mesorectal excisions with anal sphincter preservation in patients with rectal cancer. World J Gastroenterol. 2003;9(12):2690-2694. https://doi.org/10.3748/wjg.v9.i12.2690
  24. Delgado S, Lacy AM, Filella X, Castells A, García-Valdecasas JC, Pique JM, Momblán D, Visa J. Acute phase response in laparoscopic and open colectomy in colon cancer: randomized study. Dis Colon Rectum. 2001;44(5):638-646.  https://doi.org/10.1007/bf02234558
  25. Schwenk W, Jacobi C, Mansmann U, Böhm B, Müller JM. Inflammatory response after laparoscopic and conventional colorectal resections — results of a prospective randomized trial. Langenbecks Arch Surg. 2000;385(1):2-9.  https://doi.org/10.1007/s004230050002
  26. Ozawa A, Konishi F, Nagai H, Okada M, Kanazawa K. Cytokine and hormonal responses in laparoscopic-assisted colectomy and conventional open colectomy. Surg Today. 2000;30(2):107-111.  https://doi.org/10.1007/s005950050024
  27. Wu FPK, Sietses C, von Blomberg BME, van Leeuwen P a. M, Meijer S, Cuesta MA. Systemic and peritoneal inflammatory response after laparoscopic or conventional colon resection in cancer patients: a prospective, randomized trial. Dis Colon Rectum. 2003;46(2):147-155.  https://doi.org/10.1007/s10350-004-6516-2
  28. Veenhof A a. FA, Sietses C, von Blomberg BME, van Hoogstraten IMW, vd Pas MHGM, Meijerink WJHJ, vd Peet DL, vd Tol MP, Bonjer HJ, Cuesta MA. The surgical stress response and postoperative immune function after laparoscopic or conventional total mesorectal excision in rectal cancer: a randomized trial. Int J Colorectal Dis. 2011;26(1):53-59.  https://doi.org/10.1007/s00384-010-1056-9
  29. Aleksanyan GB, Akhmatova EA, Akhmatova NK, Kurbatova EA, Panchenkov DN, Zverev VV. Balans Thl/Th2/Th9/Thl7/Th22 tsitokinov v posleoperatsionnom periode u patsientov so zlokachestvennymi opukholyami pecheni. Zhurnal mikrobiologii, epidemiologii i immunobiologii (ZhMEI). 2017;(2):66-74. (In Russ.). https://doi.org/10.36233/0372-9311-2017-2-66-74
  30. Yuan Q, Walker WA. Innate immunity of the gut: mucosal defense in health and disease. J Pediatr Gastroenterol Nutr. 2004;38(5):463-473.  https://doi.org/10.1097/00005176-200405000-00001
  31. Ikushima H, Nishida T, Takeda K, Ito T, Yasuda T, Yano M, Akira S, Matsuda H. Expression of Toll-like receptors 2 and 4 is downregulated after operation. Surgery. 2004;135(4):376-385.  https://doi.org/10.1016/j.surg.2003.08.016
  32. Thurairajah K, Briggs GD, Balogh ZJ. The source of cell-free mitochondrial DNA in trauma and potential therapeutic strategies. Eur J Trauma Emerg Surg. 2018;44(3):325-334.  https://doi.org/10.1007/s00068-018-0954-3
  33. Hauser CJ, Otterbein LE. Danger signals from mitochondrial DAMPS in trauma and post-injury sepsis. Eur J Trauma Emerg Surg. 2018;44(3):317-324.  https://doi.org/10.1007/s00068-018-0963-2
  34. Schietroma M, Piccione F, Carlei F, Clementi M, Bianchi Z, de Vita F, Amicucci G. Peritonitis from perforated appendicitis: stress response after laparoscopic or open treatment. Am Surg. 2012;78(5):582-590.  https://doi.org/10.1177/000313481207800541
  35. Veenhof A a. FA, Vlug MS, van der Pas MHGM, Sietses C, van der Peet DL, de Lange-de Klerk ESM, Bonjer HJ, Bemelman WA, Cuesta MA. Surgical stress response and postoperative immune function after laparoscopy or open surgery with fast track or standard perioperative care: a randomized trial. Ann Surg. 2012;255(2):216-221.  https://doi.org/10.1097/SLA.0b013e31824336e2
  36. Fretland AA, Sokolov A, Postriganova N, Kazaryan AM, Pischke SE, Nilsson PH, Rognes IN, Bjornbeth BA, Fagerland MW, Mollnes TE, Edwin B. Inflammatory Response After Laparoscopic Versus Open Resection of Colorectal Liver Metastases. Medicine (Baltimore). 2015;94(42). https://doi.org/10.1097/MD.0000000000001786
  37. Kang R, Tang D, Schapiro NE, Loux T, Livesey KM, Billiar TR, Wang H, Van Houten B, Lotze MT, Zeh HJ. The HMGB1/RAGE inflammatory pathway promotes pancreatic tumor growth by regulating mitochondrial bioenergetics. Oncogene. 2014;33(5):567-577.  https://doi.org/10.1038/onc.2012.631
  38. Kazaryan AM, Marangos IP, Røsok BI, Rosseland AR, Villanger O, Fosse E, Mathisen O, Edwin B. Laparoscopic resection of colorectal liver metastases: surgical and long-term oncologic outcome. Ann Surg. 2010;252(6):1005-1012. https://doi.org/10.1097/SLA.0b013e3181f66954
  39. Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH. Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg. 1999;230(3):309-318; discussion 318-321.  https://doi.org/10.1097/00000658-199909000-00004
  40. Hao TB, Shi W, Shen XJ, Qi J, Wu XH, Wu Y, Tang YY, Ju SQ. Circulating cell-free DNA in serum as a biomarker for diagnosis and prognostic prediction of colorectal cancer. Br J Cancer. 2014;111(8):1482-1489. https://doi.org/10.1038/bjc.2014.470
  41. Schlecker E, Stojanovic A, Eisen C, Quack C, Falk CS, Umansky V, Cerwenka A. Tumor-infiltrating monocytic myeloid-derived suppressor cells mediate CCR5-dependent recruitment of regulatory T cells favoring tumor growth. J Immunol. 2012;189(12):5602-5611. https://doi.org/10.4049/jimmunol.1201018
  42. Tsimogiannis KE, Tellis CC, Tselepis AD, Pappas-Gogos GK, Tsimoyiannis EC, Basdanis G. Toll-like receptors in the inflammatory response during open and laparoscopic colectomy for colorectal cancer. Surg Endosc. 2012;26(2):330-336.  https://doi.org/10.1007/s00464-011-1871-2
  43. Agier J, Krawczyk K, Żelechowska P, Kozłowska E, Brzezińska-Błaszczyk E, Wiktorska M. Expression of Toll-like receptors 2 and 4 on peripheral mononuclear cells (PBMCs) after laparoscopic cholecystectomy. Scand J Clin Lab Invest. 2019;79(6):449-454.  https://doi.org/10.1080/00365513.2019.1658895
  44. Kasai M, Van Damme N, Berardi G, Geboes K, Laurent S, Troisi RI. The inflammatory response to stress and angiogenesis in liver resection for colorectal liver metastases: a randomized controlled trial comparing open versus laparoscopic approach. Acta Chir Belg. 2018;118(3):172-180.  https://doi.org/10.1080/00015458.2017.1407118
  45. Desai KH, Tan CS, Leek JT, Maier RV, Tompkins RG, Storey JD, Program and the I and the HR to IL-SCR. Dissecting Inflammatory Complications in Critically Injured Patients by Within-Patient Gene Expression Changes: A Longitudinal Clinical Genomics Study. PLOS Medicine. 2011;8(9):e1001093. https://doi.org/10.1371/journal.pmed.1001093
  46. Johnson SB, Lissauer M, Bochicchio GV, Moore R, Cross AS, Scalea TM. Gene expression profiles differentiate between sterile SIRS and early sepsis. Ann Surg. 2007;245(4):611-621.  https://doi.org/10.1097/01.sla.0000251619.10648.32
  47. Decker D, Schondorf M, Bidlingmaier F, Hirner A, von Ruecker AA. Surgical stress induces a shift in the type-1/type-2 T-helper cell balance, suggesting down-regulation of cell-mediated and up-regulation of antibody-mediated immunity commensurate to the trauma. Surgery. 1996;119(3):316-325.  https://doi.org/10.1016/s0039-6060(96)80118-8
  48. Whelan RL, Franklin M, Holubar SD, Donahue J, Fowler R, Munger C, Doorman J, Balli JE, Glass J, Gonzalez J-J, Bessler M, Xie H, Treat M. Postoperative cell mediated immune response is better preserved after laparoscopic vs open colorectal resection in humans. Surg Endosc. 2003;17(6):972-978.  https://doi.org/10.1007/s00464-001-8263-y
  49. Huang C, Huang R, Jiang T, Huang K, Cao J, Qiu Z. Laparoscopic and open resection for colorectal cancer: an evaluation of cellular immunity. BMC Gastroenterol. 2010;10:127.  https://doi.org/10.1186/1471-230X-10-127
  50. Lee SW, Whelan RL. Immunologic and oncologic implications of laparoscopic surgery: what is the latest? Clin Colon Rectal Surg. 2006;19(1):5-12.  https://doi.org/10.1055/s-2006-939525
  51. Fujii K, Sonoda K, Izumi K, Shiraishi N, Adachi Y, Kitano S. T lymphocyte subsets and Th1/Th2 balance after laparoscopy-assisted distal gastrectomy. Surg Endosc. 2003;17(9):1440-1444. https://doi.org/10.1007/s00464-002-9149-3
  52. Panchenkov DN, Alikhanov RB, Ivanov YuV, Shablovskii OR, Baranov AV, Solov’ev NA, Nechunaev AA, Aleksanyan GB. Laparoskopicheski assistirovannaya rezektsiya pecheni pri vyrazhennom spaechnom protsesse. Annaly khirurgicheskoi gepatologii. 2014;19(3):17-20. (In Russ.).
  53. Efanov MG, Alikhanov RB, Tsvirkun VV, Kazakov IV, Kim PP, Van’kovich AN, Akhaladze DG, Grendal’ KD, Zamanov EN. Blizhaishie i otdalennye rezul’taty laparoskopicheskikh i robot-assistirovannykh rezektsii pecheni. Otsenka opyta spetsializirovannogo tsentra. Annaly khirurgicheskoi gepatologii. 2018;23(1):38-46. (In Russ.).
  54. Vetshev PS, Chzhao AV, Ionkin DA, Stepanova YuA, Zhavoronkova OI, Kulezneva YuV, Melekhina OV, Panchenkov DN, Astakhov DA, Ivanov YuV, Bruslik SV, Sviridova TI. Primenenie miniinvazivnykh tekhnologii dlya ablyatsii zlokachestvennykh opukholei podzheludochnoi zhelezy. Annaly khirurgicheskoi gepatologii. 2019;24(3):87-98. (In Russ.). https://doi.org/10.16931/1995-5464.2019387-98
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