In the article authors display short-term results of the right-sided hemicolectomy performed by 3 different types of laparoscopic approach: multiport, hand-assistant, and single port laparoscopy. There were 42 patients in the 1st group, 43 in the 2nd group, and 22 in the 3rd group. Female patients prevailed in all three groups. There weren’t any statistical difference in age and BMI between the groups. During the study authors analyzed intraoperative findings and postoperative course and morphological criteria of the dissected colon. In particular, analysis of time of surgery, some technical aspects of the surgery, blood loss, length of minilaparotomy incision, evaluation of postoperative pain, length of the dissected colon, morphometric characteristics of the tumor, the length of the vascular bundle, the number of dissected lymph nodes. Based on the results of comparative analysis, the tendency to reduce postoperative hospital stay, and reduce severity of pain syndrome, along with a minimum length of the skin incision was shown in patients undergoing single port laparoscopic access. However, more data are necessary, further accumulation of material and conducting prospective randomized trials.