The effect of alverine citrate plus simethicone (Meteospazmyl ) on effectiveness and tolerability of bowel preparation for colonoscopy

Kashin S.V.; Zavyalov D.V.; Sidneva A.V.

doi:https://doi.org/10.17116/dokgastro20231202134

Kashin S.V.

Yaroslavl Regional Oncology Hospital

ORCID: 0000-0001-6098-7677

Zavyalov D.V.

Yaroslavl State Medical University

ORCID: 0000-0002-9173-6878

Sidneva A.V.

Yaroslavl State Medical University

ORCID: 0009-0002-0609-4485

The effect of alverine citrate plus simethicone (Meteospazmyl ) on effectiveness and tolerability of bowel preparation for colonoscopy

Authors:

Kashin S.V., Zavyalov D.V., Sidneva A.V.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2023;12(2): 34‑44

DOI: 10.17116/dokgastro20231202134

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To cite this article:

Kashin SV, Zavyalov DV, Sidneva AV. The effect of alverine citrate plus simethicone (Meteospazmyl ) on effectiveness and tolerability of bowel preparation for colonoscopy. Russian Journal of Evidence-Based Gastroenterology. 2023;12(2):34‑44. (In Russ.)
https://doi.org/10.17116/dokgastro20231202134

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)

Использование инфографики авторами научных работ

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OBJECTIVE

To evaluate the impact of Meteospasmil on the effectiveness and tolerability of colonoscopy preparation.

MATERIALS AND METHODS

A prospective, single-center, comparative, randomized study included 65 patients who were randomly assigned to two groups. The first group (n=32) received standard two-stage osmotic laxative (Eziklen) preparation. The second group (n=33) received the same bowel preparation regimen with the addition of Meteospasmil. All patients had at least one risk factor for poor bowel preparation or poor tolerability. Bowel preparation quality was assessed using the Ottawa scale.

RESULTS

Excellent or good bowel preparation was achieved in all patients. The presence of colonic bubbles during colonoscopy was significantly lower in the Meteospasmil group (3.1%) compared to the non- Meteospasmil group (61%) (p<0.001). The total duration of colonoscopy was also significantly shorter in the Meteospasmil group (12.4 minutes) compared to the non- Meteospasmil group (14.8 minutes) (p=0.04). Polyps were detected in 35.5% of patients in the Meteospasmil group and 30.3% in the non- Meteospasmil group, but the difference was not statistically significant.

CONCLUSION

The combination of the low-volume one-liter preparation Eziklen with predictable high-quality bowel cleansing, high safety, and Meteospasmil is a new direction in improving bowel cleansing quality in patient groups at increased risk of poor preparation.

Keywords:

colonoscopy

bowel preparation

colonic bubles

alverine citrate

simethicone

Authors:

Kashin S.V.

Yaroslavl Regional Oncology Hospital

ORCID: 0000-0001-6098-7677

Zavyalov D.V.

Yaroslavl State Medical University

ORCID: 0000-0002-9173-6878

Sidneva A.V.

Yaroslavl State Medical University

ORCID: 0009-0002-0609-4485

Received:

25.04.2023

Accepted:

07.05.2023

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References:

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