The presence of residual stool, bile, colonic bubbles, colonic dysmotility and spasm can hamper visualization of the colonic mucosa, increasing the risk of lesions being missed. Novel approach for overcoming colonic spasm as well as bubbles is peroral antispasmodic agent alverine citrate with simethicone.
OBJECTIVE
To evaluate the impact of Meteospasmil on the effectiveness and tolerability of colonoscopy preparation.
MATERIALS AND METHODS
A prospective, single-center, comparative, randomized study included 65 patients who were randomly assigned to two groups. The first group (n=32) received standard two-stage osmotic laxative (Eziklen) preparation. The second group (n=33) received the same bowel preparation regimen with the addition of Meteospasmil. All patients had at least one risk factor for poor bowel preparation or poor tolerability. Bowel preparation quality was assessed using the Ottawa scale.
RESULTS
Excellent or good bowel preparation was achieved in all patients. The presence of colonic bubbles during colonoscopy was significantly lower in the Meteospasmil group (3.1%) compared to the non- Meteospasmil group (61%) (p<0.001). The total duration of colonoscopy was also significantly shorter in the Meteospasmil group (12.4 minutes) compared to the non- Meteospasmil group (14.8 minutes) (p=0.04). Polyps were detected in 35.5% of patients in the Meteospasmil group and 30.3% in the non- Meteospasmil group, but the difference was not statistically significant.
CONCLUSION
The combination of the low-volume one-liter preparation Eziklen with predictable high-quality bowel cleansing, high safety, and Meteospasmil is a new direction in improving bowel cleansing quality in patient groups at increased risk of poor preparation.