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Maev I.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Osadchuk M.A.

I.M. Sechenov First Moscow State Medical University

Krylova Yu.S.

Acad. I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia

Osadchuk M.M.

City Polyclinic No. 52 of the Department of Health of the City of Moscow

Mironova E.D.

I.M. Sechenov First Moscow State Medical University

Hudarova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Motilin, vascular endothelial growth factor, and somatostatin expression in the gastric mucosa of patients with NSAID-gastropathy

Authors:

Maev I.V., Osadchuk M.A., Krylova Yu.S., Osadchuk M.M., Mironova E.D., Hudarova A.A.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2022;11(4): 22‑31

DOI: 10.17116/dokgastro20221104122

Read: 1928 times

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Table of contents

MOTILIN, VASCULAR ENDOTHELIAL GROWTH FACTOR, AND SOMATOSTATIN EXPRESSION IN THE GASTRIC MUCOSA OF PATIENTS WITH NSAID-GASTROPATHY
MOTILIN, VASCULAR ENDOTHELIAL GROWTH FACTOR, AND SOMATOSTATIN EXPRESSION IN THE GASTRIC MUCOSA OF PATIENTS WITH NSAID-GASTROPATHY

To cite this article:

Maev IV, Osadchuk MA, Krylova YuS, Osadchuk MM, Mironova ED, Hudarova AA. Motilin, vascular endothelial growth factor, and somatostatin expression in the gastric mucosa of patients with NSAID-gastropathy. Russian Journal of Evidence-Based Gastroenterology. 2022;11(4):22‑31. (In Russ.)
https://doi.org/10.17116/dokgastro20221104122

Подписка 2026 Доказательная гастроэнтерология (Russian Journal of Evidence-Based Gastroenterology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To determine the level of expression of motilin (MT), vascular endothelial growth factor (VEGF), and somatostatin (SS) in the antral gastric mucosa in patients with NSAID gastropathy.

MATERIAL AND METHODS

153 patients using NSAIDs and 40 individuals not using NSAIDs were included in the study. All patients were divided into 4 groups: 1st — 51 people with NSAID gastropathy caused by acetylsalicylic acid; 2nd — 50 with NSAID-gastropathy caused by selective COX-2 inhibitors; 3rd — 52 without NSAID gastropathy, taking selective COX-2 inhibitors; 4th (comparison group) — 40 people not using NSAIDs. Patients underwent esophagogastroduodenoscopy with targeted biopsy of the antral gastric mucosa. The biopsy samples underwent cytological and immunohistochemical tests to verify Helicobacter pylori and determine MT, SS, and VEGF expression.

RESULTS

Diabetes mellitus, gastroesophageal reflux disease, and arterial hypertension were more prevalent in patients with NSAID gastropathy than in the 3d group (p<0.05). The incidence of stomach ulcers was twice as high in the 2nd group as it was in the 1st. The relative areas of VEGF, SS, and MT expression in the antral mucosa varied between all groups (p<0.05). In contrast to patients in the 3rd group, those with erosive and ulcerative lesions of the stomach had a lower relative area of VEGF and SS expression and a higher relative area of MT expression. The expression of these hormones was also lower in the 2nd group than in the 1st group (p<0.05).

CONCLUSIONS

VEGF, MT, and SS are crucial factors in the development of NSAID gastropathy. The absence of NSAID-gastropathy in the 3rd group without significant changes in the expression of VEGF, MT, and SS suggests the presence of some mechanisms that inhibit the development of erosive lesions in the gastric mucosa by stabilizing the local hormonal system.

Keywords:

motilin
somatostatin
vascular endothelial growth factor
Non-Steroidal Anti-Inflammatory Agents
gastropathy

Authors:

Maev I.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Osadchuk M.A.

I.M. Sechenov First Moscow State Medical University

Krylova Yu.S.

Acad. I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia

Osadchuk M.M.

City Polyclinic No. 52 of the Department of Health of the City of Moscow

Mironova E.D.

I.M. Sechenov First Moscow State Medical University

Hudarova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

04.06.2022

Accepted:

26.09.2022

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References:

  1. Bindu S, Mazumder S, Bandyopadhyay U. Non-steroidal anti-inflammatory drugs (NSAIDs) and organ damage: A current perspective. Biochemical Pharmacology. 2020;180:114147. https://doi.org/10.1016/j.bcp.2020.114147
  2. Svistunov AA, Osadchuk MA, Kireeva NV, Hudarova AA, Achkasov EE. NSAID-induced enteropathy: the current state of the problem. Terapevticheskii arkhiv. 2018;90(8):95-100. (In Russ.). https://doi.org/10.26442/terarkh201890895-100
  3. Vakhrushev YM, Zagrebina EA. Enteropathy induced by nonsteroid anti-inflammatory drugs: pathogenesis, diagnosis, treatment. Terapevticheskii arkhiv. 2012;84(5):74-79. (In Russ.).
  4. Tai FWD, McAlindon ME. NSAIDs and the small bowel. Current Opinion in Gastroenterology. 2018;34(3):175-182.  https://doi.org/10.1097/MOG.0000000000000427
  5. Maseda D, Ricciotti E. NSAID-Gut Microbiota Interactions. Frontiers in Pharmacology. 2020;11:1153. https://doi.org/10.3389/fphar.2020.01153
  6. Sandoval-Acuña C, Lopez-Alarcón C, Aliaga ME, Speisky H. Inhibition of mitochondrial complex I by various non-steroidal anti-inflammatory drugs and its protection by quercetin via a coenzyme Q-like action. Chemico-biological Interactions. 2012; 199(1):18-28.  https://doi.org/10.1016/j.cbi.2012.05.006
  7. Farrugia G, Balzan R. The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells. Oxidative Medicine and Cellular Longevity. 2013;2013:504230. https://doi.org/10.1155/2013/504230
  8. Rosas C, Sinning M, Ferreira A, Fuenzalida M, Lemus D. Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy. Biological Research. 2014;47:27.  https://doi.org/10.1186/0717-6287-47-27
  9. Melincovici CS, Boşca AB, Şuşman S, Mărginean M, Mihu C, Istrate M, Moldovan IM, Roman AL, Mihu CM. Vascular endothelial growth factor (VEGF) — key factor in normal and pathological angiogenesis. Romanian Journal of Morphology and Embryology. 2018;59(2):455-467. 
  10. Oshima H, Ishikawa T, Yoshida GJ, Naoi K, Maeda Y, Naka K, Ju X, Yamada Y, Minamoto T, Mukaida N, Saya H, Oshima M. TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. Oncogene. 2014;33(29):3820-3829. https://doi.org/10.1038/onc.2013.356
  11. Corleto VD. Somatostatin and the gastrointestinal tract. Current Opinion in Endocrinology, Diabetes, and Obesity. 2010;17(1):63-68.  https://doi.org/10.1097/MED.0b013e32833463ed
  12. Creutzfeldt W, Arnold R. Somatostatin and the stomach: exocrine and endocrine aspects. Metabolism. 1978;27(9 suppl 1):1309-1315. https://doi.org/10.1016/0026-0495(78)90064-1
  13. Kim DU, Moon JH, Lee YH, Paik SS, Kim Y, Kim YJ. Analysis of Somatostatin-Secreting Gastric Delta Cells according to Upper Abdominal Symptoms and Helicobacter pylori Infection in Children. Pediatric Gastroenterology, Hepatology&Nutrition. 2020; 23(3):243-250.  https://doi.org/10.5223/pghn.2020.23.3.243
  14. Park SM, Lee HR, Kim JG, Park JW, Jung G, Han SH, Cho JH, Kim MK. Effect of Helicobacter pylori infection on antral gastrin and somatostatin cells and on serum gastrin concentrations. Korean Journal of Internal Medicine. 1999;(14):15-20.  https://doi.org/10.3904/kjim.1999.14.1.15
  15. Peeters TL. Ghrelin: a new player in the control of gastrointestinal functions. Gut. 2005;54(11):1638-1649. https://doi.org/10.1136/gut.2004.062604
  16. Poitras P, Peeters TL. Motilin. Current Opinion in Endocrinology, Diabetes, and Obesity. 2008;15(1):54-57.  https://doi.org/10.1097/MED.0b013e3282f370af
  17. Fiorucci S, Morelli A. Motilin and erythromycin stimulate pepsinogen secretion by chief cells isolated from guinea pig stomach. Gastroenterology. 1993;104(4):1030-1036. https://doi.org/10.1016/0016-5085(93)90270-m
  18. Goyal RK, Guo Y, Mashimo H. Advances in the physiology of gastric emptying. Neurogastroenterology and Motility. 2019;31(4): e13546. https://doi.org/10.1111/nmo.13546
  19. Svistunov AA, Osadchuk MA, Mironova ED, Guliaev PV, Vasileva IN. The role of the main risk factors and endocrine cells of the antrum of the stomach producing motilin in the occurrence of cholelithiasis. Terapevticheskii arkhiv. 2022;94(2):194-199. (In Russ.). https://doi.org/10.26442/00403660.2022.02.201370
  20. Haans JJ, Masclee AA. Intragastric acidification inhibits motilin-induced phase III activity in humans. Neurogastroenterology and Motility. 2006;18(8):637-646.  https://doi.org/10.1111/j.1365-2982.2006.00797.x
  21. Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KE, Pritchard DM, Rugge M, Sonnenberg A, Sugano K, Tack J. The stomach in health and disease. Gut. 2015;64(10):1650-1668. https://doi.org/10.1136/gutjnl-2014-307595
  22. Mussa BM, Sood S, Verberne AJ. Implication of neurohormonal-coupled mechanisms of gastric emptying and pancreatic secretory function in diabetic gastroparesis. World Journal of Gastroenterology. 2018;24(34):3821-3833. https://doi.org/10.3748/wjg.v24.i34.3821
  23. Sonnenberg A. Concordant occurrence of gastric and hypertensive diseases. Gastroenterology. 1988;95(1):42-48.  https://doi.org/10.1016/0016-5085(88)90288-0
  24. Tey KR, Kemmerly T, Banerjee B. NSAID-induced pyloric stenosis leading to oesophageal intramucosal dissection. BMJ Case Reports. 2016;2016:bcr2016215777. https://doi.org/10.1136/bcr-2016-215777
  25. Boehme MWJ, Autschbach F, Ell C, Raeth U. Prevalence of silent gastric ulcer, erosions or severe acute gastritis in patients with type 2 diabetes mellitus-a cross-sectional study. Hepatogastroenterology. 2007;54(74):643-648. 
  26. Gelbenegger G, Postula M, Pecen L, Halvorsen S, Lesiak M, Schoergenhofer C, Jilma B, Hengstenberg C, Siller-Matula JM. Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups. BMC Medicine. 2019;17(1):198.  https://doi.org/10.1186/s12916-019-1428-0
  27. Tarnawski AS, Ahluwalia A, Jones MK. Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging. Journal of Gastroenterology and Hepatology. 2014;29(suppl 4):112-123.  https://doi.org/10.1111/jgh.12734
  28. Ferrara N. The role of VEGF in the regulation of physiological and pathological angiogenesis. EXS. 2005;(94):209-231.  https://doi.org/10.1007/3-7643-7311-3_15
  29. Narita T, Okabe N, Hane M, Yamamoto Y, Tani K, Naito Y, Hara S. Nonsteroidal anti-inflammatory drugs induce hypermotilinemia and disturbance of interdigestive migrating contractions in instrumented dogs. Journal of Veterinary Pharmacology and Therapeutics. 2006;29(6):569-577.  https://doi.org/10.1111/j.1365-2885.2006.00805.x
  30. Goswami C, Shimada Y, Yoshimura M, Mondal A, Oda S, Tanaka T, Sakai T, Sakata I. Motilin Stimulates Gastric Acid Secretion in Coordination with Ghrelin in Suncus murinus. PLoS One. 2015;10(6):e0131554. https://doi.org/10.1371/journal.pone.0131554
  31. Yao YL, Xu B, Zhang WD, Song YG. Gastrin, somatostatin, and experimental disturbance of the gastrointestinal tract in rats. World Journal of Gastroenterology. 2001;7(3):399-402.  https://doi.org/10.3748/wjg.v7.i3.399
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