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Maev I.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Osadchuk M.A.

I.M. Sechenov First Moscow State Medical University

Krylova Yu.S.

Acad. I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia

Osadchuk M.M.

City Polyclinic No. 52 of the Department of Health of the City of Moscow

Mironova E.D.

I.M. Sechenov First Moscow State Medical University

Hudarova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Motilin, vascular endothelial growth factor, and somatostatin expression in the gastric mucosa of patients with NSAID-gastropathy

Authors:

Maev I.V., Osadchuk M.A., Krylova Yu.S., Osadchuk M.M., Mironova E.D., Hudarova A.A.

More about the authors

Journal: Russian Journal of Evidence-Based Gastroenterology. 2022;11(4): 22‑31

DOI: 10.17116/dokgastro20221104122

Views: 1224

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Table of contents

MOTILIN, VASCULAR ENDOTHELIAL GROWTH FACTOR, AND SOMATOSTATIN EXPRESSION IN THE GASTRIC MUCOSA OF PATIENTS WITH NSAID-GASTROPATHY
MOTILIN, VASCULAR ENDOTHELIAL GROWTH FACTOR, AND SOMATOSTATIN EXPRESSION IN THE GASTRIC MUCOSA OF PATIENTS WITH NSAID-GASTROPATHY

To cite this article:

Maev IV, Osadchuk MA, Krylova YuS, Osadchuk MM, Mironova ED, Hudarova AA. Motilin, vascular endothelial growth factor, and somatostatin expression in the gastric mucosa of patients with NSAID-gastropathy. Russian Journal of Evidence-Based Gastroenterology. 2022;11(4):22‑31. (In Russ.)
https://doi.org/10.17116/dokgastro20221104122

 
Подписка 2025-2 (Russian Journal of Evidence-Based Gastroenterology)
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OBJECTIVE

To determine the level of expression of motilin (MT), vascular endothelial growth factor (VEGF), and somatostatin (SS) in the antral gastric mucosa in patients with NSAID gastropathy.

MATERIAL AND METHODS

153 patients using NSAIDs and 40 individuals not using NSAIDs were included in the study. All patients were divided into 4 groups: 1st — 51 people with NSAID gastropathy caused by acetylsalicylic acid; 2nd — 50 with NSAID-gastropathy caused by selective COX-2 inhibitors; 3rd — 52 without NSAID gastropathy, taking selective COX-2 inhibitors; 4th (comparison group) — 40 people not using NSAIDs. Patients underwent esophagogastroduodenoscopy with targeted biopsy of the antral gastric mucosa. The biopsy samples underwent cytological and immunohistochemical tests to verify Helicobacter pylori and determine MT, SS, and VEGF expression.

RESULTS

Diabetes mellitus, gastroesophageal reflux disease, and arterial hypertension were more prevalent in patients with NSAID gastropathy than in the 3d group (p<0.05). The incidence of stomach ulcers was twice as high in the 2nd group as it was in the 1st. The relative areas of VEGF, SS, and MT expression in the antral mucosa varied between all groups (p<0.05). In contrast to patients in the 3rd group, those with erosive and ulcerative lesions of the stomach had a lower relative area of VEGF and SS expression and a higher relative area of MT expression. The expression of these hormones was also lower in the 2nd group than in the 1st group (p<0.05).

CONCLUSIONS

VEGF, MT, and SS are crucial factors in the development of NSAID gastropathy. The absence of NSAID-gastropathy in the 3rd group without significant changes in the expression of VEGF, MT, and SS suggests the presence of some mechanisms that inhibit the development of erosive lesions in the gastric mucosa by stabilizing the local hormonal system.

Keywords:

motilin
somatostatin
vascular endothelial growth factor
Non-Steroidal Anti-Inflammatory Agents
gastropathy

Authors:

Maev I.V.

A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Osadchuk M.A.

I.M. Sechenov First Moscow State Medical University

Krylova Yu.S.

Acad. I.P. Pavlov First Saint Petersburg State Medical University of the Ministry of Health of Russia

Osadchuk M.M.

City Polyclinic No. 52 of the Department of Health of the City of Moscow

Mironova E.D.

I.M. Sechenov First Moscow State Medical University

Hudarova A.A.

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Received:

04.06.2022

Accepted:

26.09.2022

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