Gastric tumors with GLI1 gene alterations (plexiform fibromyxoma and gastroblastoma). Case report and literature review

Sidorov I.V.; Sharlai A.S.; Konovalov D.M.

doi:https://doi.org/10.17116/patol20258701137

Sidorov I.V.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

ORCID: 0000-0001-8578-6572

Sharlai A.S.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Konovalov D.M.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology;
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0001-7732-8184

Gastric tumors with GLI1 gene alterations (plexiform fibromyxoma and gastroblastoma). Case report and literature review

Authors:

Sidorov I.V., Sharlai A.S., Konovalov D.M.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2025;87(1): 37‑40

DOI: 10.17116/patol20258701137

Read: 843 times

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To cite this article:

Sidorov IV, Sharlai AS, Konovalov DM. Gastric tumors with GLI1 gene alterations (plexiform fibromyxoma and gastroblastoma). Case report and literature review. Russian Journal of Archive of Pathology. 2025;87(1):37‑40. (In Russ.)
https://doi.org/10.17116/patol20258701137

Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)

Использование инфографики авторами научных работ

Abstract:

Plexiform fibromyxoma (PFM) and gastroblastoma (GB) are rare gastric tumors with a specific MALAT1::GLI1 rearrangement, included in the conditional spectrum of neoplasms with alterations of the GLI1 gene. The article presents a clinical case of PFM in a 6-year-old girl and a literature review highlighting current data on the morphology, immunophenotype and molecular genetic characteristics of PFM and GB. Despite the common genetic anomaly, differences in the morphology and clinical course of these tumors indicate the need for further research to clarify their relationship and potential reclassification in the light of new data on tumors with GLI1 gene abnormalities. Integrating the accumulated knowledge about tumors with GLI1 gene alterations into diagnostic algorithms and therapeutic approaches will help improve the treatment outcomes of patients with these rare neoplasms.

Keywords:

plexiform fibromyxoma

gastroblastoma

MALAT1::GLI1

GLI1 gene

Authors:

Sidorov I.V.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

ORCID: 0000-0001-8578-6572

Sharlai A.S.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Konovalov D.M.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology;
Russian Medical Academy of Continuous Professional Education

ORCID: 0000-0001-7732-8184

Received:

21.06.2024

Accepted:

30.10.2024

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