The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 101-59-87
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2024
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Konyukova A.K.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery;
Savelyeva Moscow City Clinical Hospital No. 31;
Russian Medical Academy of Continuous Professional Education

Kozlova M.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Pechnikova V.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Shapovaliants S.G.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Mikhalev A.I.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Bolikhov K.V.

Pirogov Russian National Research Medical University

Shulaev A.V.

Savelyeva Moscow City Clinical Hospital No. 31

Pathological changes in the muscular tissue of the colon in diverticular disease

Authors:

Konyukova A.K., Mikhaleva L.M., Kozlova M.A., Areshidze D.A., Pechnikova V.V., Shapovaliants S.G., Mikhalev A.I., Bolikhov K.V., Shulaev A.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(4): 13‑22

DOI: 10.17116/patol20248604113

Views: 506

Downloaded: 81

Download PDF (RU)
Contact the author
Table of contents

To cite this article:

Konyukova AK, Mikhaleva LM, Kozlova MA, et al. . Pathological changes in the muscular tissue of the colon in diverticular disease. Russian Journal of Archive of Pathology. 2024;86(4):13‑22. (In Russ.)
https://doi.org/10.17116/patol20248604113

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Close metadata
Recommended articles:
Methods of pancreatic fibrosis asse­ssment. Russian Journal of Evidence-Based Gastroenterology. 2024;(1):48-57
Pharmacological prevention of fibrosis in dacryosurgery. Russian Annals of Ophthalmology. 2024;(2-2):180-189

The high incidence of colonic diverticular disease (DD) in the general population is a serious public health problem. According to statistics, DD is among the top five most common colorectal diseases. Complicated course of DD is observed in 12—15% of patients, and in 10.7% of cases can lead to death. Algorithms and recommendations for predicting the complicated course of DD for further prevention have not been developed.

OBJECTIVE

Comparative analysis of clinical data and structural characteristics of the colonic muscular tissue in patients with different course of DD and without colonic diverticula to identify morphological predictors of a complicated DD.

MATERIAL AND METHODS

A comparative analysis of clinical data, pathomorphological and ultrastructural changes of the colonic musculature in the surgical material from 68 patients undergoing left-sided hemicolectomy was carried out.

RESULTS

The operative material of 37 patients with complicated course of DD, 19 with uncomplicated course of DD and 12 without diverticula was analyzed. In men, this disease occurs at a younger age than in women (Median age of men 49 (39.5; 61) years, women 66.5 (58; 81) years; U=178, p<0.001). It was shown that the area occupied by connective tissue fibres in the colonic musculature in patients with a complicated DD was 5 times greater (15%) than in observations with an uncomplicated DD (3%) and 50 times greater than in cases without colonic diverticula (0.3%; p<0.001).

CONCLUSION

The present study demonstrates age- and sex-specific features of DD, as well as significant differences in the prevalence of fibrosis of the colonic musculature, which can be considered as a potential predictor of a complicated course of DD.

Keywords:

diverticular disease
DD
complicated course
fibrosis
morphological predictors

Authors:

Konyukova A.K.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery;
Savelyeva Moscow City Clinical Hospital No. 31;
Russian Medical Academy of Continuous Professional Education

Kozlova M.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Pechnikova V.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Shapovaliants S.G.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Mikhalev A.I.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Bolikhov K.V.

Pirogov Russian National Research Medical University

Shulaev A.V.

Savelyeva Moscow City Clinical Hospital No. 31

Received:

25.01.2024

Accepted:

24.04.2024

List of references:

  1. Konyukova AK, Shapoval’yants SG, Mikhalev AI, Bolikhov KV, Shulaev AV, Gutyrchik NA, Mikhaleva LM. Morphological and genetic predictors of the complicated course of colon diverticulosis. Clinical and Experimental Morphology. 2022;11(3):5-14. (In Russ.). https://doi.org/10.31088/CEM2022.11.3.5-14
  2. Bates DDB, Fernandez MB, Ponchiardi C, von Plato M, Teich JP, Narsule C, Anderson SW, Gupta A, LeBedis CA. Surgical management in acute diverticulitis and its association with multi-detector CT, modified Hinchey classification, and clinical parameters. Abdom Radiol (NY). 2018;43(8):2060-2065. https://doi.org/10.1007/s00261-017-1422-y
  3. Drapkina OM, Lazebnik LB, Bakulin IG, Skazyvaeva EV, Bakulina NV, Sitkin SI, Skalinskaya MI, Zhuravleva MS, Avalueva EB, Livzan MA, Bordin DS, Khavkin AI. Diverticular disease of the colon: clinical picture, diagnosis, treatment and prevention. Experimental and Clinical Gastroenterology. 2023;210(2):33-69. (In Russ.). https://doi.org/10.31146/1682-8658-ecg-210-2-33-69
  4. Talutis SD, Kuhnen FAH. Pathophysiology and epidemiology of diverticular disease. Clin Colon Rectal Surg. 2020;34(2):81-85.  https://doi.org/10.1055/s-0040-1716698
  5. Tursi A, Scarpignato C, Strate LL, Lanas A, Kruis W, Lahat A, Danese S. Colonic diverticular disease. Nat Rev Dis Primers. 2020;6(1):20.  https://doi.org/10.1038/s41572-020-0153-5
  6. Ardatskaya MD, Podstavkina IS, Mordasova VI, Korotkikh NN, Garush’yan GV. Retrospective analysis of the prevalence, features of the course, treatment and outcomes of diverticular disease according to data of a multidifilinary hospital. Experimental and Clinical Gastroenterology. 2020;176(4):77-82. (In Russ.). https://doi.org/10.31146/1682-8658-ecg-176-4-77-82
  7. Humes DJ. Changing epidemiology: does it increase our understanding? Dig Dis. 2012;30(1):6-11.  https://doi.org/10.1159/000335692
  8. Pittet O, Kotzampassakis N, Schmidt S, Denys A, Demartines N, Calmes JM. Recurrent left colonic diverticulitis episodes: more severe than the initial diverticulitis? World J Surg. 2009;33(3):547-552.  https://doi.org/10.1007/s00268-008-9898-9
  9. Levchuk AL, Abdullaev EG, Abdullaev AE. Diagnosis of acute colon diverticulitis and its complications. Bulletin of the National Medical and Surgical Center named after N.I. Pirogov. 2021;16(3):25-31. (In Russ.). https://doi.org/10.25881/20728255_2021_16_3_25
  10. Cameron R, Walker MM, Thuresson M, Roelstraete B, Sköldberg F, Olén O, Talley NJ, Ludvigsson JF. Mortality risk increased in colonic diverticular disease: a nationwide cohort study. Ann Epidemiol. 2022;76:39-49.  https://doi.org/10.1016/j.annepidem.2022.10.006
  11. Peery AF, Shaukat A, Strate LL. AGA clinical practice update on medical management of colonic diverticulitis: expert review. Gastroenterology. 2021;160(3):906-911.e1.  https://doi.org/10.1053/j.gastro.2020.09.059
  12. Balkanov A, Rozanov ID, Galanov A, Gaganov LE, Chernikov VP. Endothelium changes of peritumoral zone capillaries after brain glioblastoma adjuvant radiation therapy. Clin Exp Morphol. 2021; 10(1):33-40.  https://doi.org/10.31088/CEM2021.10.1.33-40
  13. Reynolds ES The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963;17(1): 208-212.  https://doi.org/10.1083/jcb.17.1.208
  14. Schultz JK, Azhar N, Binda GA, Barbara G, Biondo S, Boermeester MA, Chabok A, Consten ECJ, van Dijk ST, Johanssen A, et al. European Society of Coloproctology: guidelines for the management of diverticular disease of the colon. Colorectal Dis. 2020;22(suppl 2):5-28.  https://doi.org/10.1111/codi.15140
  15. Peery AF, Keil A, Jicha K, Galanko JA, Sandler RS. Association of obesity with colonic diverticulosis in women. Clin Gastroenterol Hepatol. 2020;18(1):107-14.e1.  https://doi.org/10.1016/j.cgh.2019.04.058
  16. Barbaro MR, Cremon C, Fuschi D, Marasco G, Palombo M, Stanghellini V, Barbara G. Pathophysiology of diverticular disease: from diverticula formation to symptom generation. Int J Mol Sci. 2022;23(12):6698. https://doi.org/10.3390/ijms23126698
  17. Vorontsov OF, Tolochik VV, Mikhin IV, Kitaeva AV, Graeb K. Diverticular disease: from tradition to innovation. Bulletin of VolSMU. 2020;(4):92-95. (In Russ.). https://doi.org/10.19163/1994-9480-2020-4(76)-92-95
  18. Tursi A. Current and evolving concepts on the pathogenesis of diverticular disease. J Gastrointestin Liver Dis. 2019;28:225-235.  https://doi.org/10.15403/jgld-184
  19. Hawkins AT, Wise PE, Chan T, Lee JT, Glyn T, Wood V, Eglinton T, Frizelle F, Khan A, Hall J, et al. Diverticulitis: an update from the age old paradigm. Curr Probl Surg. 2020;57(10):100862. https://doi.org/10.1016/j.cpsurg.2020.100862
  20. Zashikhin AL, Agafonov YuV. On the issue of phenotypic differences in smooth myocytes that are part of visceral and vascular smooth muscle tissue. Questions of Morphology of the XXI century. 2010;(2):134-138. (In Russ.).

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register


We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.