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Konyukova A.K.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery;
Savelyeva Moscow City Clinical Hospital No. 31;
Russian Medical Academy of Continuous Professional Education

Kozlova M.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Pechnikova V.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Shapovaliants S.G.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Mikhalev A.I.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Bolikhov K.V.

Pirogov Russian National Research Medical University

Shulaev A.V.

Savelyeva Moscow City Clinical Hospital No. 31

Pathological changes in the muscular tissue of the colon in diverticular disease

Authors:

Konyukova A.K., Mikhaleva L.M., Kozlova M.A., Areshidze D.A., Pechnikova V.V., Shapovaliants S.G., Mikhalev A.I., Bolikhov K.V., Shulaev A.V.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2024;86(4): 13‑22

DOI: 10.17116/patol20248604113

Read: 1878 times

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Table of contents

PATHOLOGICAL CHANGES IN THE MUSCULAR TISSUE OF THE COLON IN DIVERTICULAR DISEASE
PATHOLOGICAL CHANGES IN THE MUSCULAR TISSUE OF THE COLON IN DIVERTICULAR DISEASE

To cite this article:

Konyukova AK, Mikhaleva LM, Kozlova MA, et al. . Pathological changes in the muscular tissue of the colon in diverticular disease. Russian Journal of Archive of Pathology. 2024;86(4):13‑22. (In Russ.)
https://doi.org/10.17116/patol20248604113

 
Подписка 2026 Архив патологии (Russian Journal of Archive of Pathology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The high incidence of colonic diverticular disease (DD) in the general population is a serious public health problem. According to statistics, DD is among the top five most common colorectal diseases. Complicated course of DD is observed in 12—15% of patients, and in 10.7% of cases can lead to death. Algorithms and recommendations for predicting the complicated course of DD for further prevention have not been developed.

OBJECTIVE

Comparative analysis of clinical data and structural characteristics of the colonic muscular tissue in patients with different course of DD and without colonic diverticula to identify morphological predictors of a complicated DD.

MATERIAL AND METHODS

A comparative analysis of clinical data, pathomorphological and ultrastructural changes of the colonic musculature in the surgical material from 68 patients undergoing left-sided hemicolectomy was carried out.

RESULTS

The operative material of 37 patients with complicated course of DD, 19 with uncomplicated course of DD and 12 without diverticula was analyzed. In men, this disease occurs at a younger age than in women (Median age of men 49 (39.5; 61) years, women 66.5 (58; 81) years; U=178, p<0.001). It was shown that the area occupied by connective tissue fibres in the colonic musculature in patients with a complicated DD was 5 times greater (15%) than in observations with an uncomplicated DD (3%) and 50 times greater than in cases without colonic diverticula (0.3%; p<0.001).

CONCLUSION

The present study demonstrates age- and sex-specific features of DD, as well as significant differences in the prevalence of fibrosis of the colonic musculature, which can be considered as a potential predictor of a complicated course of DD.

Keywords:

diverticular disease
DD
complicated course
fibrosis
morphological predictors

Authors:

Konyukova A.K.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery;
Savelyeva Moscow City Clinical Hospital No. 31;
Russian Medical Academy of Continuous Professional Education

Kozlova M.A.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Areshidze D.A.

Russian Scientific Centre of Surgery named after Academician B.V. Petrovsky

Pechnikova V.V.

Avtsyn Research Institute of Human Morphology of Petrovsky National Research Centre of Surgery

Shapovaliants S.G.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Mikhalev A.I.

Pirogov Russian National Research Medical University;
Savelyeva Moscow City Clinical Hospital No. 31

Bolikhov K.V.

Pirogov Russian National Research Medical University

Shulaev A.V.

Savelyeva Moscow City Clinical Hospital No. 31

Received:

25.01.2024

Accepted:

24.04.2024

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References:

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