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Sharlai A.S.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Gegeliya N.V.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Druy A.E.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Konovalov D.M.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology;
Russian Medical Academy of Continuous Professional Education

«Malignant stroma?» Alternative localization of classical genetic aberrations in neuroblastoma

Authors:

Sharlai A.S., Gegeliya N.V., Druy A.E., Konovalov D.M.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2023;85(4): 47‑53

DOI: 10.17116/patol20238504147

Views: 646

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To cite this article:

Sharlai AS, Gegeliya NV, Druy AE, Konovalov DM. «Malignant stroma?» Alternative localization of classical genetic aberrations in neuroblastoma. Russian Journal of Archive of Pathology. 2023;85(4):47‑53. (In Russ.)
https://doi.org/10.17116/patol20238504147

Подписка 2025 (Russian Journal of Archive of Pathology)
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Neuroblastoma (NB) is a malignant neoplasm originating from the primary cells of the sympathetic nervous system. Patients with NB are risk-stratified using a number of features including age at diagnosis, disease stage, tumor histology and genetic profile (status of NMYC, ALK genes, regions 1p and 11q). The interpretation of the results of genetic studies can become a source of problems because neuroblastoma has a heterogeneous histological pattern. The article describes 2 cases with classical for NB chromosomal aberrations in the stromal component of the tumor.

Keywords:

neuroblastoma
Schwannian stroma
copy number variations
1p
11q

Authors:

Sharlai A.S.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Gegeliya N.V.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Druy A.E.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Konovalov D.M.

Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology;
Russian Medical Academy of Continuous Professional Education

Received:

10.01.2023

Accepted:

19.04.2023

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