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Kuznetsova A.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry;
N.K. Koltsov Institute of Developmental Biology

Popova O.P.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Astakhov D.A.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Ivanov Yu.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Panchenkov D.N.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Ivanov A.A.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Epithelial-stromal interactions in pancreatic adenocarcinoma: the role of stroma in disease progression

Authors:

Kuznetsova A.V., Popova O.P., Astakhov D.A., Ivanov Yu.V., Panchenkov D.N., Ivanov A.A.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(5): 65‑70

DOI: 10.17116/patol20228405165

Views: 1971

Downloaded: 52

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To cite this article:

Kuznetsova AV, Popova OP, Astakhov DA, Ivanov YuV, Panchenkov DN, Ivanov AA. Epithelial-stromal interactions in pancreatic adenocarcinoma: the role of stroma in disease progression. Russian Journal of Archive of Pathology. 2022;84(5):65‑70. (In Russ.)
https://doi.org/10.17116/patol20228405165

Подписка 2025 (Russian Journal of Archive of Pathology)
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Pancreatic ductal adenocarcinoma (PDAC) is the most common and difficult to treat form of pancreas cancer. PDAC and other solid cancers contain both tumor cells and normal connective tissue cells called stromal cells, which are responsible for the excess production of extracellular matrix. It is known that in more than 90% of PDAC tumors and in many other types of cancer, mutations of the KRAS gene are observed, the reciprocal signaling of which has been shown between tumor and stromal cells in vitro. Pancreatic stromal stellate cells are considered precursors of activated or tumor-associated fibroblasts (CAFs), which are an increasing population of cells that proliferate in situ or are recruited into the tumor. CAFs are a heterogeneous population of stromal fibroblasts with different molecular profiles that change during tumorigenesis. Both immunosuppressive and immunosuppressive subsets of CAFs can coexist in the stroma of a single tumor. Based on the heterogeneity of the intertumor stroma, attempts are being made to classify PDAC and predict the course of the disease.

Keywords:

pancreatic ductal adenocarcinoma
PDAC
tumor microenvironment
cancer-associated fibroblasts
CAFs
inter-tumor stroma

Authors:

Kuznetsova A.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry;
N.K. Koltsov Institute of Developmental Biology

Popova O.P.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Astakhov D.A.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Ivanov Yu.V.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Panchenkov D.N.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Ivanov A.A.

A.I. Evdokimov Moscow State University of Medicine and Dentistry

Received:

27.04.2022

Accepted:

22.06.2022

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