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Chulkova S.V.
N.N. Blokhin National Medical Research Center of Oncology;
N.I. Pirogov Russian National Research Medical University
Loginov V.I.
Institute of General Pathology and Pathophysiology
Podluzhny D.V.
Blokhin National Medical Research Center of Oncology
Egorova A.V.
N.I. Pirogov Russian National Research Medical University
Syskova A.Yu.
N.I. Pirogov Russian National Research Medical University
Gladilina I.A.
N.N. Blokhin National Medical Research Center of Oncology;
N.I. Pirogov Russian National Research Medical University
Kudashkin N.E.
Blokhin National Medical Research Center of Oncology;
Pirogov Russian National Research Medical University
The role of molecular genetic factors in the development of cholangiocellular carcinoma
Journal: Russian Journal of Archive of Pathology. 2022;84(3): 76‑83
Views: 1807
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To cite this article:
Chulkova SV, Loginov VI, Podluzhny DV, et al. . The role of molecular genetic factors in the development of cholangiocellular carcinoma. Russian Journal of Archive of Pathology.
2022;84(3):76‑83. (In Russ.)
https://doi.org/10.17116/patol20228403176
The article lists the main inducers of cholangiocarcinogenesis. The main inflammatory mediators (IL-6, nitric oxide, COX2) have been considered. Data on the study of gene mutations in cholangiocarcinomas are presented. The spectrum of genetic mutations depends on the biliary cancer origin (FGFR2 with intrahepatic cholangiocarcinoma, PRKACA, PRKACB with extrahepatic cholangiocarcinoma). Mutations in the KRAS, TP53, ARIAD1A genes are common in extrahepatic bile duct cancer. The role of epigenetic changes such as DNA hypermethylation, histone modifications, chromatin remodeling, as well as disturbances in miRNA expression is presented. A number of epigenetic features, such as the presence of a TP53 mutations with hypermethylation of p14ARF, DAPK, and/or ASC, correlate with a more aggressive course of the disease. The role of the SOX17 gene in the development of drug resistance is highlighted. The study of the molecular genetic features of extrahepatic bile duct cancer can help to better understand the pathogenesis of this type of tumor, to establish new prognostic and diagnostic markers of the disease.
Authors:
Chulkova S.V.
N.N. Blokhin National Medical Research Center of Oncology;
N.I. Pirogov Russian National Research Medical University
Loginov V.I.
Institute of General Pathology and Pathophysiology
Podluzhny D.V.
Blokhin National Medical Research Center of Oncology
Egorova A.V.
N.I. Pirogov Russian National Research Medical University
Syskova A.Yu.
N.I. Pirogov Russian National Research Medical University
Gladilina I.A.
N.N. Blokhin National Medical Research Center of Oncology;
N.I. Pirogov Russian National Research Medical University
Kudashkin N.E.
Blokhin National Medical Research Center of Oncology;
Pirogov Russian National Research Medical University
Received:
02.02.2022
Accepted:
10.03.2022
List of references:
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