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Ryzhova M.V.

Burdenko Neurosurgical Center

Galstyan S.A.

Burdenko Neurosurgical Center

Telysheva E.N.

Burdenko Neurosurgical Center

Significance of DNA methylation assessment in the morphological diagnosis of brain tumours

Authors:

Ryzhova M.V., Galstyan S.A., Telysheva E.N.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(3): 65‑75

DOI: 10.17116/patol20228403165

Read: 5215 times

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Table of contents

SIGNIFICANCE OF DNA METHYLATION ASSESSMENT IN THE MORPHOLOGICAL DIAGNOSIS OF BRAIN TUMOURS
SIGNIFICANCE OF DNA METHYLATION ASSESSMENT IN THE MORPHOLOGICAL DIAGNOSIS OF BRAIN TUMOURS

To cite this article:

Ryzhova MV, Galstyan SA, Telysheva EN. Significance of DNA methylation assessment in the morphological diagnosis of brain tumours. Russian Journal of Archive of Pathology. 2022;84(3):65‑75. (In Russ.)
https://doi.org/10.17116/patol20228403165

Подписка 2025-2 (Russian Journal of Archive of Pathology)
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The review is focused on a relatively new research method in oncology — DNA methylation. Starting from the methylation of individual genes, the method is gradually expanding and becoming routine for studying the global structure of DNA methylation (methylome) in tumors of various localizations. For some tumors (carcinomas of the mammary and thyroid glands), the study of the global structure of DNA methylation is just beginning, while methylation classifiers have been proposed and successfully used in the Russian Federation for brain tumours and sarcomas. This article compares the fifth edition of the WHO Classification of tumours of the Central Neurvous System and the methylation brain classifier.

Keywords:

DNA methylation
brain tumours
sarcomas

Authors:

Ryzhova M.V.

Burdenko Neurosurgical Center

Galstyan S.A.

Burdenko Neurosurgical Center

Telysheva E.N.

Burdenko Neurosurgical Center

Received:

12.01.2022

Accepted:

10.03.2022

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