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Ryzhova M.V.

Burdenko Neurosurgical Center

Galstyan S.A.

Burdenko Neurosurgical Center

Telysheva E.N.

Burdenko Neurosurgical Center

Shaikhaev E.G.

Burdenko Neurosurgical Center

Snigireva G.P.

Burdenko Neurosurgical Center

Gorelyshev S.K.

Burdenko Neurosurgical Center

Kadyrov Sh.U.

Burdenko Neurosurgical Center

Shimansky V.N.

Burdenko Neurosurgical Center

Shugai S.V.

Burdenko Neurosurgical Center

Panina T.N.

Burdenko Neurosurgical Center

Sarcomas of the central nervous systems. Clinical observations

Authors:

Ryzhova M.V., Galstyan S.A., Telysheva E.N., Shaikhaev E.G., Snigireva G.P., Gorelyshev S.K., Kadyrov Sh.U., Shimansky V.N., Shugai S.V., Panina T.N.

More about the authors

Journal: Russian Journal of Archive of Pathology. 2022;84(3): 40‑47

DOI: 10.17116/patol20228403140

Views: 1779

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To cite this article:

Ryzhova MV, Galstyan SA, Telysheva EN, et al. . Sarcomas of the central nervous systems. Clinical observations. Russian Journal of Archive of Pathology. 2022;84(3):40‑47. (In Russ.)
https://doi.org/10.17116/patol20228403140

Подписка 2025 (Russian Journal of Archive of Pathology)
МСФ на ЯМ
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Here we report three patients with rare primary intracranial sarcomas, two of them were CIC-sarcomas and one was a DICER1-sarcoma. Tumors were examined using DNA methylation. It is important to study of CIC fusions and DICER1 mutations in malignant brain tumors.

Keywords:

DNA methylation
brain tumours
CNS sarcomas

Authors:

Ryzhova M.V.

Burdenko Neurosurgical Center

Galstyan S.A.

Burdenko Neurosurgical Center

Telysheva E.N.

Burdenko Neurosurgical Center

Shaikhaev E.G.

Burdenko Neurosurgical Center

Snigireva G.P.

Burdenko Neurosurgical Center

Gorelyshev S.K.

Burdenko Neurosurgical Center

Kadyrov Sh.U.

Burdenko Neurosurgical Center

Shimansky V.N.

Burdenko Neurosurgical Center

Shugai S.V.

Burdenko Neurosurgical Center

Panina T.N.

Burdenko Neurosurgical Center

Received:

16.02.2022

Accepted:

10.03.2022

List of references:

  1. WHO Classification of Tumours Editorial Board. Central nervous system tumours. Lyon: IARC; 2021. (WHO classification of tumours series. 5th ed.; vol. 6). https://tumourclassification.iarc.who.int/chapters/45
  2. WHO Classification of Tumours Editorial Board. Soft tissue and bone tumours. Lyon: IARC; 2020. (WHO classification of tumours series. 5th ed.; vol. 5). https://tumourclassification.iarc.who.int/https://tumourclassification.iarc.who.int/chapter/
  3. WHO Classification of Tumours Editorial Board. Paediatric tumours. Lyon: IARC; 2021. (WHO classification of tumours series. 5th ed.; vol. 5). https://tumourclassification.iarc.who.int/https://tumourclassification.iarc.who.int/chapter/
  4. Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary. Neuro Oncol. 2021;23(8):1231-1251. https://doi.org/10.1093/neuonc/noab106
  5. Kallen ME, Hornick JL. The 2020 WHO Classification what’s new in soft tissue tumor pathology? Am J Surg Pathol. 2021;45(1):1-23.  https://doi.org/10.1097/PAS.0000000000001552
  6. Sbaraglia M, Bellan E, Dei Tos AP. The 2020 WHO Classification of Soft Tissue Tumours: news and perspectives. Pathologica. 2021;113:70-84.  https://doi.org/10.32074/1591-951X-213
  7. Pfister SM, Reyes-Múgica M, Chan JKC, Hasle H, Lazar AJ, Rossi S, Ferrari A, Jarzembowski JA, Pritchard-Jones K, Hill DA, et al. A summary of the Inaugural WHO Classification of Pediatric Tumors: Transitioning from the optical into the molecular era. Cancer Discov. 2022;12(2):331-355.  https://doi.org/10.1158/2159-8290.CD-21-1094
  8. Miettinen M, Felisiak-Golabek A, Contreras AL, Glod J, Kaplan RN, Killian JK, Lasota J. New fusion sarcomas: histopathology and clinical significance of selected entities Hum Pathol. 2019;86:57-65.  https://doi.org/10.1016/j.humpath.2018.12.006.
  9. Łastowska M, Trubicka J, Sobocińska A, Wojtas B, Niemira M, Szałkowska A, Krętowski A, Karkucińska-Więckowska A, Kaleta M, Ejmont M, et al. Molecular identification of CNS NB-FOXR2, CNS EFT-CIC, CNS HGNET-MN1 and CNS HGNET-BCOR pediatric brain tumors using tumor-specific signature genes. Acta Neuropathol Commun. 2020;8(1):105.  https://doi.org/10.1186/s40478-020-00984-9
  10. Koelsche C, Mynarek M, Schrimpf D, Bertero L, Serrano J, Sahm F, Reuss DE, Hou Y, Baumhoer D, Vokuhl C, et al. Primary intracranial spindle cell sarcoma with rhabdomyosarcomalike features share a highly distinct methylation profile and DICER1 mutations. Acta Neuropathol. 2018;136(2):327-337.  https://doi.org/10.1007/s00401-018-1871-6
  11. Schultz KAP, Stewart DR, Kamihara J, et al. DICER1 tumor predisposition. 2014 Apr 24 [Updated 2020 Apr 30]. In: Adam MP, Ardinger HH, Pagon RA, et al, eds. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2022. https://www.ncbi.nlm.nih.gov/books/
  12. Warren M, Hiemenz MC, Schmidt R, Shows J, Cotter J, Toll S, Parham DM, Biegel JA, Mascarenhas L, Shah R. Expanding the spectrum of dicer1-associated sarcomas. Mod Pathol. 2020;33(1): 164-174.  https://doi.org/10.1038/s41379-019-0366-x
  13. Roy P, Das A, Singh A, Panda Y, Bhattacharya A, Gehani A, Parihar M, Reghu KS, Achari R, Alaggio R, Field A, Hill DA, Dehner LP, Schultz KAP. Phenotypic similarities within themorphologic spectrum of DICER1-associated sarcomas and pleuropulmonary blastoma: Histopathologic features guide diagnosis in the LMIC setting. Pediatr Blood Cancer. 2022;69:e29466. https://doi.org/10.1002/pbc.29466
  14. WHO Classification of Tumours Editorial Board. Thoracic tumours. Lyon: IARC; 2021. (WHO classification of tumours series. 5th ed.; vol. 5). https://tumourclassification.iarc.who.int/chapters/35
  15. Lee JC, Villanueva-Meyer JE, Ferris SP, Sloan EA, Hofmann JW, Hattab EM, Williams BJ, Guo H, Torkildson J, Florez A, Van Ziffle J, Onodera C, Grenert JP, Cho S-J, Horvai AE, et al. Primary intracranial sarcomas with DICER1 mutation often contain prominent eosinophilic cytoplasmic globules and can occur in the setting of neurofibromatosis type 1. Acta Neuropathol. 2019;137(3):521-525.  https://doi.org/10.1007/s00401-019-01960-x
  16. https://doi.org/10.17116/neiro20218506192  https://doi.org/10.17116/neiro20218506198

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